HealthCare–Associated Infections in the Nursery

Coffin, Susan; Zaoutis, Theoklis E.

doi:10.1016/b978-1-4160-6400-8.00035-3

Cited by 9 publications

(6 citation statements)

References 235 publications

(267 reference statements)

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“…Alcohol swabs alone are ineffective in preventing omphalitis. 11 Class II is defined by erythema of the surrounding tissue and is still a local inflammatory process. Class III includes either class I or class II with systemic involvement.…”

Section: Discussionmentioning

confidence: 99%

Periumbilical Erythema in a Neonate

Henbest¹,

Steele²

2013

Clin Pediatr (Phila)

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Section: Discussionmentioning

confidence: 99%

Periumbilical Erythema in a Neonate

Henbest¹,

Steele²

2013

Clin Pediatr (Phila)

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“…The intervention will be preceded by a formative study which will be conducted in the Kampala, Mukono and Wakiso districts. The reason for focusing on HCFs and departments that offer MNCH services is because mothers and neonates are at a greater risk of getting exposed to HCAIs [4][5][6], and there is therefore critical need to improve the status of WASH in maternal and children's wards. The study will be guided by the "Behaviour Centred Design (BCD)" model and theory for behaviour change [30], which guides hand hygiene program design through the "ABCDE" (Assess, Build, Create, Deliver and Evaluate) steps (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…The lack of WASH infrastructure compromises the ability to provide safe and quality healthcare services, and places both healthcare workers (HCWs) and patients at a considerable and yet preventable health risk of HCAIs. Indeed there is a strong biological plausibility that pathogens responsible for HCAIs are more prevalent in facilities with substandard WASH services [3], and mothers and neonates are at the greatest risk of getting exposed to HCAIs [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Impact of mhealth messages and environmental cues on hand hygiene practice among healthcare workers in the greater Kampala metropolitan area, Uganda: study protocol for a cluster randomized trial

Mugambe

Mselle

Ssekamatte

et al. 2021

BMC Health Serv Res

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Background Hand hygiene (HH) among healthcare workers (HCWs) is critical for infection prevention and control (IPC) in healthcare facilities (HCFs). Nonetheless, it remains a challenge in HCFs, largely due to lack of high-impact and efficacious interventions. Environmental cues and mobile phone health messaging (mhealth) have the potential to improve HH compliance among HCWs, however, these remain under-studied. Our study will determine the impact of mhealth hygiene messages and environmental cues on HH practice among HCWs in the Greater Kampala Metropolitan Area (GKMA). Methods The study is a cluster-randomized trial, which will be guided by the behaviour centred design model and theory for behaviour change. During the formative phase, we shall conduct 30 key informants’ interviews and 30 semi-structured interviews to explore the barriers and facilitators to HCWs’ HH practice. Besides, observations of HH facilities in 100 HCFs will be conducted. Findings from the formative phase will guide the intervention design during a stakeholders’ insight workshop. The intervention will be implemented for a period of 4 months in 30 HCFs, with a sample of 450 HCWs who work in maternity and children’s wards. HCFs in the control arm will receive innovatively designed HH facilities and supplies. HCWs in the intervention arm, in addition to the HH facilities and supplies, will receive environmental cues and mhealth messages. The main outcome will be the proportion of utilized HH opportunities out of the 9000 HH opportunities to be observed. The secondary outcome will be E. coli concentration levels in 100mls of hand rinsates from HCWs, an indicator of recent fecal contamination and HH failure. We shall run multivariable logistic regression under the generalized estimating equations (GEE) framework to account for the dependence of HH on the intervention. Discussion The study will provide critical findings on barriers and facilitators to HH practice among HCWs, and the impact of environmental cues and mhealth messages on HCWs’ HH practice. Trial registration ISRCTN Registry with number ISRCTN98148144. The trial was registered on 23/11/2020.

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“…In neonates, long-term antibiotic therapy is associated with emergence of resistant bacteria, superimposed fungal infections, and increased risk of necrotizing enterocolitis ( 6 ). Additional risks associated with long-term antibiotic therapy include need for central vascular access and its attendant complications ( 7 ). Thus, infants may sustain harm not only from meningitis but also from associated interventions.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics

2017

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Neonatal meningitis is a devastating condition. Prognosis has not improved in decades, despite the advent of improved antimicrobial therapy and heightened index of suspicion among clinicians caring for affected infants. One in ten infants die from meningitis, and up to half of survivors develop significant lifelong complications, including seizures, impaired hearing and vision, and delayed or arrested development of such basic skills as talking and walking. At present, it is not possible to predict which infants will suffer poor outcomes. Early treatment is critical to promote more favorable outcomes, though diagnosis of meningitis in infants is technically challenging, time-intensive, and invasive. Profound neuronal injury has long been described in the setting of neonatal meningitis, as has elevated levels of many pro- and anti-inflammatory cytokines. Mechanisms of the host immune response that drive clearance of the offending organism and underlie brain injury due to meningitis are not well understood, however. In this review, we will discuss challenges in diagnosis, prognosis, and treatment of neonatal meningitis. We will highlight transcriptomic, proteomic, and metabolomic data that contribute to suggested mechanisms of inflammation and brain injury in this setting with a view toward fruitful areas for future investigation.

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HealthCare–Associated Infections in the Nursery

Cited by 9 publications

References 235 publications

Periumbilical Erythema in a Neonate

Periumbilical Erythema in a Neonate

Impact of mhealth messages and environmental cues on hand hygiene practice among healthcare workers in the greater Kampala metropolitan area, Uganda: study protocol for a cluster randomized trial

Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics

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