The purpose of the article was to study unintentional pharmaceutical-related poisonings committed by laypersons that were reported to the Toxicological Information Centre in the Czech Republic. Identifying frequency, sources, reasons and consequences of the medication errors in laypersons could help to reduce the overall rate of medication errors. Records of medication error enquiries from 2013 to 2014 were extracted from the electronic database, and the following variables were reviewed: drug class, dosage form, dose, age of the subject, cause of the error, time interval from ingestion to the call, symptoms, prognosis at the time of the call and first aid recommended. Of the calls, 1354 met the inclusion criteria. Among them, central nervous system-affecting drugs (23.6%), respiratory drugs (18.5%) and alimentary drugs (16.2%) were the most common drug classes involved in the medication errors. The highest proportion of the patients was in the youngest age subgroup 0-5 year-old (46%). The reasons for the medication errors involved the leaflet misinterpretation and mistaken dose (53.6%), mixing up medications (19.2%), attempting to reduce pain with repeated doses (6.4%), erroneous routes of administration (2.2%), psychiatric/elderly patients (2.7%), others (9.0%) or unknown (6.9%). A high proportion of children among the patients may be due to the fact that children's dosages for many drugs vary by their weight, and more medications come in a variety of concentrations. Most overdoses could be prevented by safer labelling, proper cap closure systems for liquid products and medication reconciliation by both physicians and pharmacists.Medication errors and unintentional pharmaceutical-related poisonings are important because of their potential effect on patient safety. Therefore, it is essential to carefully review data that characterize such adverse events [1]. Several studies presented medication errors committed by healthcare professionals and in healthcare facilities [2,3]. It was discovered by comparing inpatient and outpatient records that 49% of patients discharged from the hospital sustained at least one medication error [4]. However, trends among out-of-hospital medication errors caused by laypersons have been only scarcely reviewed despite their impact on people, therapeutic effectiveness and significant costs for the healthcare system [5]. Learning more about the occurrence of medication errors may help to prevent such unwanted situations.In our study, we investigated the frequency, age-related trends, reasons and consequences, prognosis and other characteristics on the annual rate of medication error calls to the Toxicological Information Centre (TIC) in the Czech Republic.
Materials and MethodsThe TIC is the only toxicology unit of its kind situated in the Czech Republic, which has a population of over 10 million people.TIC provides healthcare professionals and laypersons 24/7/365 with information concerning toxicity and management of a different range of substances [6,7]. Every phone call is...