Due to their intimate contact with sick patients, nurses working in public hospitals are more likely to catch COVID-19. They must, therefore, be well-versed in COVID-19 prevention strategies if they are to reduce the danger of the virus spreading to susceptible patients. Nurses are better prepared to give their patients safe and effective care if they are informed about the virus’s mechanisms of transmission, symptoms, and how to utilize personal protective equipment (PPE). As a result, this study was carried out to evaluate the level of awareness of COVID-19 prevention among nurses working in Dhaka, Bangladesh’s public hospitals. Three public tertiary hospitals in Dhaka, Bangladesh, were the sites of a descriptive type cross-sectional study with a sample size of 384 from October 2021 to December 2021. According to the study’s findings, a total of 93.25 percent of respondents had strong knowledge, whereas 6.75 percent had low knowledge. The respondent’s greatest degree of education and years of experience were substantially correlated with their level of expertise. According to the study’s findings, Dhaka’s public hospital nurses generally possess a high degree of expertise in COVID-19 prevention. To protect their safety and stop the spread of COVID-19, more training should be given on how to utilize PPE and disinfection techniques.