Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks

Abstract

Many noncommunicable diseases, such as atherosclerosis and other cardiometabolic diseases, are defined as inflammatory diseases, which suggests that multifactorial interactions linked to exacerbated disease pathology include pro-inflammatory chemical and nonchemical stressor. Recent data suggest that genetic and lifestyle factors are independently associated with susceptibility to cardiovascular diseases (Khera et al., 2016;Satija et al., 2018;Tong, 2016). Thus, potential biological interactions between chemical and nonchemical stressors and buffers and other lifestyle factors will determine disease outcome. Chemical stressors include environmental pollutants with pro-oxidant and pro-inflammatory properties, such as air pollutants, both gaseous and particulate matter, and persistent organic pollutants, such as dioxinlike polychlorinated biphenyls (PCBs). Many persistent organic pollutants also have an affinity for the aryl hydrocarbon receptor (AhR).AhR ligands lead to induction of cytochrome P450s and free radical formation, followed by inflammation. For example, dioxin-like PCBs can increase endothelial cell dysfunction, activation, and inflammation (e.g., increased adhesion molecule expression and cytokine production)

Toxicity of zearalenone and its nutritional intervention by natural products

“…In recent years, numerous natural compounds, including dietary supplements that can alleviate ZEN-induced systemic toxic effects, have received much attention from researchers. [164][165][166] Some of them are listed in Table 2. Most of the effective compounds that alleviate the toxic effects of ZEN-induced endocrine disrupting effects and oxidative stress have antioxidant activities; for instance, resveratrol, saffron, and vitamin E (Fig.…”

Healthful nutrition as a prevention and intervention paradigm to promote radiation resistance and human health

“…Undoubtedly, the governance of nuclear contamination alone will be insufficient, as most radioactive substances and contaminated environmental toxicants are ubiquitous in the ecosystem and ultimately transmit to humans through the food chain. As a result, it is urgent to explore general preventive measures for radioactive exposure and disease risks through positive lifestyle modifications such as healthy nutrition (Hennig & Deng, 2020). Based on traditional Chinese medicine, the concept of “medicine and food homology” may have a profound impact on a person's health and well‐being, which can be included in nutritional feeding programs.…”