for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK Improving diet and other lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing wellbeing. However, realising this potential will require the development, testing and implementation of much more effective behaviour change interventions than are used conventionally. Evidence-based, personalised (or stratified) interventions which incorporate effective behaviour change techniques (BCT) and which are delivered digitally are likely to be an important route to scalable and sustainable interventions. Progress in developing such interventions will depend on the outcomes of research on: (i) the best bases for personalisation of dietary advice; (ii) identification of BCT which are proven to enhance intervention efficacy; (iii) suitable platforms (digital-based tools) for collection of relevant participant characteristics (e.g. socioeconomic information, current diet and lifestyle and dietary preferences) linked with intelligent systems which use those characteristics to offer tailored feedback and advice in a cost-effective and acceptable manner. Future research should focus on such interventions aiming to reduce health inequalities and to improve overall public health.Personalised nutrition: Behaviour change: Disease prevention: Phenotype: Genotype Health is plastic and results from interactions between individual genotype and exposures plus the play of chance (1) . The important exposures include environmental contaminants, smoking and other hazardous lifestyle habits, physical activity (PA) and diet. It has been estimated that up to 80 % of major cardiometabolic diseases and over one-third of cancers could be prevented by eliminating shared risk factors, including tobacco use, poor diet, physical inactivity and excess alcohol (2) . A cluster of health behaviours, including non-smoking, being physically active, moderate alcohol intake and consumption of fruit and vegetables, is associated with up to fourfold lower mortality risk, equivalent to 14 years in chronological age (3,4) . The risk of most common diseases increases with age as does the burden of disability and frailty. A recent analysis of the global burden of ill-health demonstrated that poor diet and physical inactivity accounted for about three quarters of the top twenty factors contributing to disability-adjusted life years in the UK (5) . This emphasises the primacy of changing lifestyle factors (notably smoking cessation, increasing PA and improving diet) in public health initiatives which are aimed at improving health throughout the life-course and, especially, in adulthood.Despite considerable research on interventions to increase PA and to improve diet, in most cases the effect size achieved in such interventions is relatively modest, especially in the longer term. For example, our recent systematic review and meta-analysis of PA interventions in middle-age (55-70 years) with object...