Healthy and unhealthy aging on kidney structure and function: human studies

Đenić, Aleksandar; Rule, Andrew D.; Glassock, Richard J.

doi:10.1097/mnh.0000000000000780

Cited by 9 publications

(7 citation statements)

References 73 publications

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“…Renal fibrosis is one of the major structural features of renal aging. [ 30 ] The brain is one of the organs most affected by aging, and brain aging is one of the factors that contribute to neurodegenerative diseases. The decline of the nervous system of the brain results in morphological structural changes of nerve cells and a decrease in the number of synapses, which leads to an increase in the number of apoptotic nerve cells, resulting in brain senescence and neurodegeneration.…”

Section: Discussionmentioning

confidence: 99%

Structure Analysis, Antioxidant Activity, Anti‐Aging, and Organ Protective Effects of Pholiota adiposa Residue Polysaccharides

Minjie

et al. 2023

Starch Stärke

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The structure analysis, antioxidant activity in vitro, and organ repair evaluation of Pholiota adiposa residue polysaccharides (PRP) on d‐galactose‐induced aging mice in this work are carried out. The structural results show that PRP contains β glycoside bonded pyranose and is mainly composed of mannose glucose and galactose. The in vitro antioxidant assay demonstrates that PRP has superior reducing power and scavenging activities on hydroxyl, superoxide anion and DPPH radicals. The in vivo animal experiments confirmed that PRP can effectively increase organ index, reduce the levels of IL‐6 and TNF‐α and the contents of ALT, AST, ALP, CREA, and UA in serum induced by d‐galactose. It can significantly increase the content of HYP in skin. Meanwhile, the activities of SOD, GSH‐PX, and CAT are improved and the accumulation of MDA is reduced by repairing the structure and function of the damaged liver, kidney, and brain. These results demonstrate that PRP have certain organ protection effects on d‐galactose‐induced aging mice, indicating that it has potential application values in functional anti‐aging food and natural medicine.

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Section: Discussionmentioning

confidence: 99%

Structure Analysis, Antioxidant Activity, Anti‐Aging, and Organ Protective Effects of Pholiota adiposa Residue Polysaccharides

Minjie

et al. 2023

Starch Stärke

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“…One of the putative mechanisms linking eosinophils to CKD progression is their pro-atherogenic properties 6 . Since intrarenal arteriosclerosis/arteriolosclerosis leads to glomerulosclerosis and interstitial brosis and tubule atrophy (IFTA) [39][40][41] , and is associated with worse renal prognosis 42 , eosinophils might affect kidney outcomes by accelerating nephrosclerotic lesions. Future studies are needed to clarify the effect of eosinophils on intrarenal arteriosclerosis/arteriolosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Association between Time-Updated Eosinophil Counts and Progression of CKD

Hattori

Sakaguchi

Oka

et al. 2022

Preprint

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Patients with chronic kidney disease (CKD) have high blood eosinophil count but its clinical implication is uncertain. Since eosinophils may induce tubulointerstitial injury and arteriosclerosis, eosinophilia might be related to poor clinical outcomes. This retrospective cohort study included 2,877 patients whose estimated glomerular filtration rate (eGFR) was 10–60 mL/min/1.73 m2. The exposure was time-updated blood eosinophil counts. The outcomes were 1) initiation of renal replacement therapy (RRT) and 2) cardiovascular events and mortality. We analyzed the associations between eosinophil counts and outcomes using marginal structural models (MSM). Over a median follow-up of 6.5 years, eosinophil counts were measured a median of 22 times per patient (4 times a year per patient). There was a negative correlation between eosinophil count and eGFR. In total, 433 patients initiated RRT, 275 developed cardiovascular events, and 165 died. In MSM, higher eosinophil counts (≥ 289/µL) showed a 1.83-fold (95% confidence interval:1.33–2.51) higher rate of RRT initiation than lower eosinophil counts after adjustment for time-dependent confounders. Higher eosinophil counts were also associated with a higher rate of cardiovascular events and mortality in MSM (hazard ratio, 1.71 [95% confidence interval:1.30–2.25]). In conclusion, patients with CKD who had higher eosinophil counts showed worse kidney outcome.

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“…The volumes of the kidney cortex and medulla do not alter in parallel with healthy aging, as up to 50 years of age, cortex volume decreases, whereas medulla volume increases. Microstructural features of healthy aging include nephron loss, increase in the glomeruli (predominantly of the superficial cortex) which are globally sclerosed and ischemic, and a higher density of small interstitial fibrosis and tubular atrophy foci [ 74 ].With unhealthy aging, morbidities such as obesity and diabetes both increase AoStiff, accelerate microstructural pathology observed in aging, and contribute to disease-specific pathology, such as the solidification form of glomerulosclerosis.…”

Section: Chronic Kidney Diseasementioning

confidence: 99%

Aortic Stiffness: A Major Risk Factor for Multimorbidity in the Elderly

Triposkiadis

Xanthopoulos

Λαμπρόπουλος

et al. 2023

JCM

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Multimorbidity, the coexistence of multiple health conditions in an individual, has emerged as one of the greatest challenges facing health services, and this crisis is partly driven by the aging population. Aging is associated with increased aortic stiffness (AoStiff), which in turn is linked with several morbidities frequently affecting and having disastrous consequences for the elderly. These include hypertension, ischemic heart disease, heart failure, atrial fibrillation, chronic kidney disease, anemia, ischemic stroke, and dementia. Two or more of these disorders (multimorbidity) often coexist in the same elderly patient and the specific multimorbidity pattern depends on several factors including sex, ethnicity, common morbidity routes, morbidity interactions, and genomics. Regular exercise, salt restriction, statins in patients at high atherosclerotic risk, and stringent blood pressure control are interventions that delay progression of AoStiff and most likely decrease multimorbidity in the elderly.

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Healthy and unhealthy aging on kidney structure and function: human studies

Cited by 9 publications

References 73 publications

Structure Analysis, Antioxidant Activity, Anti‐Aging, and Organ Protective Effects of Pholiota adiposa Residue Polysaccharides

Structure Analysis, Antioxidant Activity, Anti‐Aging, and Organ Protective Effects of Pholiota adiposa Residue Polysaccharides

Association between Time-Updated Eosinophil Counts and Progression of CKD

Aortic Stiffness: A Major Risk Factor for Multimorbidity in the Elderly

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