Healthy birth after testicular extraction of sperm and <scp>ICSI</scp> from an azoospermic man with mild androgen insensitivity syndrome caused by an androgen receptor partial loss‐of‐function mutation

Massin, Nathalie; Bry, H.; Vija, Lavinia; Maione, Luigi; Constancis, E.; Haddad, Bassam; Morel, Yves; Claessens, Frank; Young, Jacques

doi:10.1111/j.1365-2265.2012.04402.x

Cited by 24 publications

(10 citation statements)

References 42 publications

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“…Any disruption of this axis produces both systemic and testicular effects that perturb sperm production. In fact, it is known that human semen quality is associated with the level of testicular androgen receptor and androgen sensitivity [56,57]. Under physiological conditions, testosterone produced by Leydig cells is bound and maintained at high level in the lumen of seminiferous tubules by Sertoli cell-specific androgen binding protein (ABP).…”

Section: Impact Of Edcs On Sperm Production In the Testis Through mentioning

confidence: 99%

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Wan

Mruk

Wong

et al. 2013

Expert Opinion on Therapeutic Targets

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Introduction Exposure to endocrine disrupting chemicals (EDCs) has recently been linked to declining fertility in men in both developed and developing countries. Since many EDCs possess intrinsic estrogenic or androgenic activities, thus, the gonad is one of the major targets of EDCs. Areas covered For the past 2 decades, studies found in the literature regarding the disruptive effects of these EDCs on reproductive function in human males and also rodents were mostly focused on oxidative stress-induced germ cell apoptosis, disruption of steroidogenesis, abnormal sperm production and disruption of spermatogenesis in particular cell adhesion function and the blood–testis-barrier (BTB) function. Herein, we highlight recent findings in the field illustrating testis-specific proteins are also targets of EDCs. Expert opinion This information should be helpful in developing better therapeutic approach to manage ECD-induced reproductive toxicity. This information is also helpful to identify potential targets for male contraceptive development.

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Section: Impact Of Edcs On Sperm Production In the Testis Through mentioning

confidence: 99%

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Wan

Mruk

Wong

et al. 2013

Expert Opinion on Therapeutic Targets

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“…The testes may be descended or not and the development of the Wolffian ducts may be normal or defective (3,19,21). The spermatogenesis has been reported to range from azoospermia to complete spermatogenesis (20,22,23). In XX males with SRY translocation, genital development results in male phenotype with small testes and azoospermia (24).…”

mentioning

confidence: 99%

Fertility outcome and information on fertility issues in individuals with different forms of disorders of sex development: findings from the dsd-LIFE study

Słowikowska-Hilczer

Hirschberg

Grinten

et al. 2017

Fertility and Sterility

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Fertility outcome is significantly reduced in all types of DSD; however, fertility potential should be assessed individually. The satisfaction with how fertility problems have been discussed can be improved. The care of patients with DSD is complex, should be individualized, and new treatment possibilities incorporated. A close collaboration in multidisciplinary teams is therefore essential to improve the situation for individuals with DSD.

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“…Serum hormone levels in both severe and mild forms of PAIS are similar to CAIS [87]. Histologically, most seminiferous tubules show no spermatogenesis, but a small minority may exhibit complete spermatogenesis [88]. The fertility status of affected individuals depends on AR mutations that affect its function and emergent phenotype resulting from a dynamic interaction between the genome and proteome.…”

Section: Defects In Androgen Actionmentioning

confidence: 93%

Fertility in Disorders of Sex Development: Evidence and Uncertainties

Foyouzi¹

2019

RMGO

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The purpose of this review is to assist health care professionals in delivering sexual-wellbeing education, fertility potential and available treatment options, initially to the parents and, subsequently, to the patient following a staged and developmentally-sensitive schedule. This review reflects a comprehensive, but necessarily selective, literature review on fertility potential and treatment options for individuals with DSD, designed to address the substantial evidentiary gaps in the medical literature on DSD treatment.

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Healthy birth after testicular extraction of sperm and ICSI from an azoospermic man with mild androgen insensitivity syndrome caused by an androgen receptor partial loss‐of‐function mutation

Cited by 24 publications

References 42 publications

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Fertility outcome and information on fertility issues in individuals with different forms of disorders of sex development: findings from the dsd-LIFE study

Fertility in Disorders of Sex Development: Evidence and Uncertainties

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