Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration

Lin, Ge

doi:10.1038/sj.bdj.2018.38

Cited by 7 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, more than half of the respondents were anxious, 58.2%. This nding is consistent with papers published locally and abroad [17][18][19][20][21][22][23][24] . The highest rates of anxiety disorder among patients with RAS was reported by Ajmal et.al.…”

Section: Anxiety Associated With Rassupporting

confidence: 92%

See 1 more Smart Citation

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Hazzaa¹

2020

Preprint

View full text Add to dashboard Cite

Aims To determine the prevalence of psychosomatic disorders among dental students with recurrent aphthous stomatitis. MethodA cross-sectional study was performed on 184 dental students with recurrent aphthous stomatitis (RAS). A p-value cut off point of 0.05 at 95% confident interval (CI) was used to determine statistical significance. Descriptive and inferential statistics were conducted where frequency and proportion were used, to present all categorical variables. Depression, Anxiety, Stress Scale questionnaires were used to assess the depression, anxiety, and stress of RAS dental students. The analysis assessed the relationship between RAS among socio-demographic characteristics of depression, anxiety, and stress by using a chi-square test.ResultsThe prevalence of depression was dominant among dental students at 62.5%. More than half of the respondents (58.2%) were anxious, whereas the prevalence of stress was lower i.e. 40.2%. There was no significant relationship found between depression and RAS (p>0.05).ConclusionAge group in years and number of ulcers in each occurrence were statistically associated for anxiety and stress, and gender was also significant to anxiety. There was no significant relationship found between depression and RAS.

show abstract

Section: Anxiety Associated With Rassupporting

confidence: 92%

“…Articles on the same subject have discussed stressful events in various forms. [21][22][23][24][25][26][27][28] The highest incidence of stress among patients with RAS was recorded by Ajmal et.al. 16 They reported that 90% of patients with RAS were exposed to stress.…”

Section: Stress Associated With Rasmentioning

confidence: 99%

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Hazzaa¹

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Many observational studies have reported positive associations between stress and mouth ulcers (Al-Omiri et al, 2012;Huling et al, 2012;Ma et al, 2015;Ge, 2018). For example, ulceration is exacerbated during examination periods and lessened during periods of vacation for students (Scully, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Psychiatric disorders are potential risk factors for mouth ulcers, as suggested by observational studies. For example, patients with depression and anxiety are more likely to develop mouth ulcers according to a series of observational studies (Huling et al, 2012;Alshahrani and Baccaglini, 2014;Ma et al, 2015;Ge, 2018); high levels of psychological stress were found in mouth ulcers patients (Gallo Cde et al, 2009); depression and neuroticism were genetically correlated with mouth ulcers (Dudding et al, 2019); and a transitory rise in salivary cortisol and/or changes in immunoregulatory activity caused by psychiatric disorders were linked to mouth ulcers (MacGregor et al, 1969;Redwine et al, 2003;Slebioda and Dorocka-Bobkowska, 2019). These observations together lead to a hypothesis that psychiatric disorders may trigger mouth ulcers.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

et al. 2020

View full text Add to dashboard Cite

BackgroundAlthough the association between mouth ulcers and psychiatric traits has been reported by observational studies, their causal relationship remains unclear. Mendelian randomization (MR), powered by large-scale genome-wide association studies (GWAS), provides an opportunity to clarify the causality between mouth ulcers and psychiatric traits.MethodsWe collected summary statistics of mouth ulcers (sample size n = 461,106) and 10 psychiatric traits from the largest publicly available GWAS on Europeans, including anxiety disorder (n = 83,566), attention deficit/hyperactivity disorder (n = 53,293), autism spectrum disorder (n = 46,350), bipolar disorder (n = 51,710), insomnia (n = 1,331,010), major depressive disorder (n = 480,359), mood instability (n = 363,705), neuroticism (n = 168,105), schizophrenia (n = 105,318), and subjective wellbeing (n = 388,538). We applied three two-sample bi-directional MR analysis methods, namely the Inverse Variance Weighted (IVW) method, the MR pleiotropy residual sum and outlier (MR-PRESSO) method, and the weighted median method, to assess the causal relationship between each psychiatric trait and mouth ulcers.ResultsWe found significant effects of autism spectrum disorder, insomnia, major depressive disorder, and subjective wellbeing on mouth ulcers, with the corresponding odds ratio (OR) from the IVW method being 1.160 [95% confidence interval (CI): 1.066–1.261, P = 5.39 × 10–4], 1.092 (1.062–1.122, P = 3.37 × 10–10), 1.234 (1.134–1.342, P = 1.03 × 10–6), and 0.703 (0.571–0.865, P = 8.97 × 10–4), respectively. We also observed suggestive evidence for mood instability to cause mouth ulcers [IVW, OR = 1.662 (1.059–2.609), P = 0.027]. These results were robust to weak instrument bias and heterogeneity. We found no evidence on causal effects between other psychiatric traits and mouth ulcers, in either direction.ConclusionOur findings suggest a protective effect of subjective wellbeing and risk effects of autism spectrum disorder, insomnia, major depressive disorder, and mood instability on mouth ulcers. These results clarify the causal relationship between psychiatric traits and the development of mouth ulcers.

show abstract

“…These include local and systemic factors such as trauma, genetics, vitamin deficiencies, immune dysfunction, stress and digestive tract disorders. [ 2 5 6 14 ] Recently, association of late bedtime and RAS has also been reported. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Association of bedtime with recurrent aphthous stomatitis

Kamat

Datar

Wadgave

et al. 2021

Journal of Oral and Maxillofacial Pathology

View full text Add to dashboard Cite

Background: Although recurrent aphthous stomatitis (RAS) is the most common oral mucosal disease, the etiology remains poorly understood till date. In addition, RAS lacks definitive therapeutic options, and hence, it becomes even more important to know the etiological factor so as to relieve the symptoms and render treatment effectively. Recently, late bedtime has been shown to be associated with RAS. Due to prolonged duty hours along with lengthy learning and training periods, late bedtime is a frequent observation among health-care professional students. However, this is a less explored field in the previous studies on RAS. Aims: This study aimed to evaluate the role of bedtime in the causation of RAS among health-care professional students. Methods: This present cross-sectional survey was carried out among medical, dental and nursing students studying in our medical campus, using an anonymous, self-administered questionnaire consisting of 18 items. The collected data was statistically analyzed and interpreted. Descriptive analysis and Chi-square tests were employed to assess the association of RAS with various variables. Results: Among a total of 1111 students who participated in the study, 39.8% ( n = 442) experienced RAS. Factors such as history of digestive tract disease, family history and stress showed a positive correlation with RAS. Interestingly, both during examination and nonexamination period, RAS was more prevalent among students with bedtime >11pm than in students with bedtime <11 pm. Conclusion: The study indicates that late bedtime is an independent risk factor for RAS and thus clinicians should focus on recommending a healthy lifestyle with adequate sleep to patients with RAS. This would benefit patients with RAS, especially health-care professional students, and could probably contribute to long-term remission in RAS.

show abstract

Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration

Cited by 7 publications

References 15 publications

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization

Association of bedtime with recurrent aphthous stomatitis

Contact Info

Product

Resources

About