Healthy Lifestyles Are Associated with Higher Lymphokine-Activated Killer Cell Activity

Inoue, Chizuru; Takeshita, Tatsuya; Kondo, Hiroshi; Morimoto, Kanehisa

doi:10.1006/pmed.1996.0111

Cited by 23 publications

(14 citation statements)

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“…In addition, our earlier studies demonstrated specifically that Japanese adults with poor lifestyle behaviors have higher frequencies of chromosomal damage (sister-chromatid exchanges, SCE), micronuclei, natural killer cell activity, lymphokineactivated killer cell activity, immunoglobulin E, and urinary mutagens (8)(9)(10)(11)(12)(13)(14). Further, for Japanese factory workers, good lifestyle behaviors are closely associated with good mental health status (15).…”

Section: Introductionmentioning

confidence: 92%

Lifestyles and Psychosomatic Symptoms among Elementary School Students and Junior High School Students

Isshiki

Morimoto

2004

Environ. Health Prev. Med.

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Objectives: To examine the relationship between lifestyles and psychosomatic symptoms in children, we conducted a self-administered questionnaire survey of elementary school students and junior high school students in Japan.Methods: We designed an original questionnaire to investigate the lifestyles and psychosomatic symptoms of children. In 1997, responses to the questionnaires were elicited from public elementary school fourth grade students (then aged 9-10) and public junior high school seventh grade students (then aged 12-13). The survey was repeated annually for three years as the students advanced through school.Results: For both boys and girls, each cross-sectional analysis revealed a strong relationship between lifestyle behaviors and psychosomatic symptoms. Psychosomatic symptoms scores varied according to daily hours of sleep, eating of breakfast, having strong likes and dislikes of food, bowel habits, and daily hours of television watching. Both boys and girls with "good" lifestyle behaviors evaluated by the HPI (Health Practice Index) showed lower scores for psychosomatic symptoms.Conclusions: These findings show that the lifestyle behaviors of children are significantly associated with psychosomatic symptoms and suggest that poor lifestyle behaviors are likely to increase physical and psychological health risks.

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Section: Introductionmentioning

confidence: 92%

Lifestyles and Psychosomatic Symptoms among Elementary School Students and Junior High School Students

Isshiki

Morimoto

2004

Environ. Health Prev. Med.

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“…Decreased NK cells have been found among people with chronic sleep deprivation, depressive symptoms, and job dissatisfaction (25,26,31). Physical inactivity and smoking have also been reported as factors disturbing NK cells (18,19). Thus it is likely that it is not the overtime work per se that causes a decrease of NK cells but rather a combination of work-related stress, sleep deprivation, depressive symptoms, and poor health behaviors triggered by overtime work.…”

Section: Nakata Et Almentioning

confidence: 99%

“…Similarly, a study of 291 middleaged male Japanese workers reported that those working ≥12 hours/day (including commuting) had a significant decrease of mitogenic response to phytohemagglutinin-A (PHA) but the levels of interferon (IFN)-γ and interleukin (IL)-4 were comparable to those working <12 hours/day (16). A series of studies assessing the immunological impact of good versus poor health practices (work hours, smoking, drinking, sleeping, exercise, nutrition, stress, and eating breakfast) revealed that working ≥10 hours/ day as compared to <10 hours/day was associated with a significant decrease of NK cell cytotoxicity (NKCC) (17), while it was not associated with lymphokine-activated killer (LAK) cell cytotoxicity or lymphocyte subsets (NK, CD4+ T, CD8+ T, perforin, granulyin, and granzymes A/B-expressing cells) (18,19).…”

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confidence: 99%

Association of overtime work with cellular immune markers among healthy daytime white-collar employees

Nakata¹,

Takahashi²,

Irie³

2011

Scand J Work Environ Health

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“…It is therefore very important to improve our life style so as to elevate NK cell function as much as possible [20,21]. Cigarette smoking, alcohol consumption, and mental stress have been reported [22,23] to significantly affect human NK cell activity [24][25][26]. To date, there have been no reports on the effect of ginkgo on human NK cell function.…”

Section: Fig 1 Effect Of Ginkgo On Natural Killer (Nk) Cells After Amentioning

confidence: 99%

The modulation of immunological activities in human NK cells by extracts of ginkgo

Matsushima

Morimoto

2009

Environ Health Prev Med

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Objective To investigate the association between extracts of ginkgo and the immune system by determining changes in natural killer (NK) cell activity and surface markers in human NK cells and by analyzing for surface markers. Methods Natural killer cell activity was determined in peripheral blood samples of three subjects who received ginkgo daily (250 ml/day; (ginkgo concentration 40 mg/ml) for 14 days by the non-radioisotopic Europium (non-RI Eu) release assay. Peripheral blood samples were taken three times during the study period: before ginkgo sample ingestion, on day 7 after ginkgo ingestion, and on day 14 after ginkgo ingestion). The peripheral blood samples were also analyzed for surface markers (CD56, CD3, CD19, CD20, CD4, CD8) using a fluorescence-activated cell sorter (FACScalibur). Results The non-RI Eu release assay revealed that the ingestion of ginkgo extracts elevated NK cell activity in the subjects, with the highest activity recorded following treatment with an extract at a concentration of 400-800 lg/ml. The analysis for surface markers using the FACScalibur showed that the expression of CD56 (NK cell surface marker) was elevated and the expression of CD19 had dropped in our subjects by day 14 of ginkgo ingestion. There was no significant difference in surface markers after 7 days of ginkgo ingestion. Conclusion Ginkgo extracts were found to affect immunological activities and surface markers (CD56) in human NK cells. Our results also reveal an optimal range of ginkgo concentration-from 400 to 800 lg/ml-within which its immunopotentiating activity is highest. It took at least 2 weeks to affect surface markers in human NK cells after ginkgo ingestion, and surface markers were not affected after 7 days of ginkgo ingestion.

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Healthy Lifestyles Are Associated with Higher Lymphokine-Activated Killer Cell Activity

Cited by 23 publications

References 0 publications

Lifestyles and Psychosomatic Symptoms among Elementary School Students and Junior High School Students

Lifestyles and Psychosomatic Symptoms among Elementary School Students and Junior High School Students

Association of overtime work with cellular immune markers among healthy daytime white-collar employees

The modulation of immunological activities in human NK cells by extracts of ginkgo

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