Healthy term and moderately preterm infants have similar cerebral oxygen saturation and cerebral blood flow volumes during early post‐natal transition

Demel, Anja; Feilke, Katharina; Schöning, M.; Wolf, M.; Poets, CF; Franz, Axel R.

doi:10.1111/apa.13023

Cited by 9 publications

(17 citation statements)

References 31 publications

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“…The absolute values of S t O 2 were comparable to previous reports using frequency domain NIRS (15,16), although several infants displayed low values ( Figure 2). It is noticeable that these values are not calibrated, but are modelled directly from in-vitro extinction coefficients of oxy-and deoxy hemoglobin.…”

Section: Discussionsupporting

confidence: 88%

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

et al. 2019

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Section: Discussionsupporting

confidence: 88%

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

et al. 2019

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“…The reflectance mode multi-distance fd-NIRS device OxiplexTS (ISS Inc. Champaign, Illinois, U.S.A.) measures mean intensity (DC), modulation amplitude (AC) and phase shift (PH) at 4 distances and 2 wavelengths and determines absolute values of cerebral oxy-, deoxy-, total hemoglobin concentration and rcStO 2 . The optode was placed, as previously described [ 9 ], in a temporo-parietal position half-way between tragus and sagittal suture. The optode was held by the examiner for 5 consecutive measurements of 1 min each at either side of the head; it was repositioned between measurement runs [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…The optode was placed, as previously described [ 9 ], in a temporo-parietal position half-way between tragus and sagittal suture. The optode was held by the examiner for 5 consecutive measurements of 1 min each at either side of the head; it was repositioned between measurement runs [ 9 ]. The tissue water content was assumed to be 90% [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Prospective observational study on assessing the hemodynamic relevance of patent ductus arteriosus with frequency domain near-infrared spectroscopy

et al. 2018

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BackgroundWhat constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking.Our objective was to evaluate associations between regional cerebral tissue oxygen saturation (rcStO2), fraction of tissue oxygen extraction (rcFtO2E) measured by frequency domain near-infrared spectroscopy (fd-NIRS) and their correlation to echocardiographic, Doppler-ultrasound, and clinical parameters in preterm infants with and without a hrPDA.MethodsIn this prospective observational study, 22 infants < 1500 g (mean [± SD]: gestational age 28.6 [±1.8] weeks, birth weight 1076 [±284] g, median (interquartile range) postnatal age at measurement 7.6 (4.6–12.9) d) with a clinical suspicion of hrPDA were analysed.Twelve infants had left-to-right shunt through PDA, and in 6 of these the PDA was classified as hrPDA based on pre-defined clinical and echocardiographic criteria. fd-NIRS, echocardiographic and Doppler-ultrasound examinations were performed. After identification of blood hemoglobin (Hb) as confounding factor, rcStO2 and rcFtO2E were corrected for this effect.ResultsOverall mean ± standard deviation (normalised to a median Hb of 13.8 mg/dl) was 57 ±5% for rcStO2 and 0.39 ±0.05 for rcFtO2E. Comparing no-hrPDA with hrPDA infants, there were no significant differences in mean rcStO2 (58 ±5% vs. 54 ±5%; p = .102), but in mean rcFtO2E (0.38 ±0.05 vs. 0.43 ±0.05; p = .038). Echocardiographic parameter and Doppler indices did not correlate with cerebral oxygenation.ConclusionOxygen transport capacity of the blood may confound NIRS data interpretation. Cerebral oxygenation determined by fd-NIRS provided additional information for PDA treatment decisions not offered by routine investigations. Whether indicating PDA therapy based on echocardiography complemented by data on cerebral oxygenation results in better outcomes should be investigated in future studies.

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“…Multi-distance methods (see Section "Multi-Distance Methods") have been employed for absolute measurements of cerebral concentration and/or saturation of hemoglobin in newborn piglets (Fantini et al, 1999;Zhang et al, 2000), in rats (Culver et al, 2003), in newborn and infants (Franceschini et al, 2007;Grant et al, 2009;Roche-Labarbe et al, 2010Lin et al, 2013b, Lin T.-Y. et al, 2016Dehaes et al, 2014Dehaes et al, , 2015Demel et al, 2014bDemel et al, , 2015Farzam et al, 2017;Ferradal et al, 2017;Schwarz et al, 2018), and in adults under normal conditions (Fantini et al, 2003;Gatto et al, 2006Gatto et al, , 2007McIntosh et al, 2010;Hallacoglu et al, 2012Hallacoglu et al, , 2013Scholkmann et al, 2013a;Clancy et al, 2015;Kainerstorfer et al, 2015;Yang and Dunn, 2015;Moreau et al, 2016;Davies et al, 2017;Blaney et al, 2019;Pham et al, 2019), under anesthesia (Paisansathan et al, 2007;Meng et al, 2012a,b), hypoxia (Davies et al, 2017), pathological conditions such as multiple sclerosis (Yang and Dunn, 2015), stroke (Moreau et al, 2016), traumatic brain injury (Davies et al, 2019), before and during electro-convulsive therapy (ECT) (Fabbri et al, 2003), during neurovascular surgery …”

Section: Absolute Measurements With a Combination Of Intensity And Phmentioning

confidence: 99%

“…Some studies have also reported the optical coefficients (µ a and µ s ) of brain tissue at discrete FD-NIRS wavelengths. This was done in newborn piglets (Fantini et al, 1999;Zhang et al, 2000), in neonates and infants (Zhao et al, 2005;Demel et al, 2014a;Farzam et al, 2017;Tian et al, 2017), and in adults (Hallacoglu et al, 2012;Blaney et al, 2019). Typically, optical properties were obtained by considering the tissue as homogeneous.…”

Section: Absolute Measurements With a Combination Of Intensity And Phmentioning

confidence: 99%

Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy

Fantini

Sassaroli

2020

Front. Neurosci.

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This article reviews the basic principles of frequency-domain near-infrared spectroscopy (FD-NIRS), which relies on intensity-modulated light sources and phase-sensitive optical detection, and its non-invasive applications to the brain. The simpler instrumentation and more straightforward data analysis of continuous-wave NIRS (CW-NIRS) accounts for the fact that almost all the current commercial instruments for cerebral NIRS have embraced the CW technique. However, FD-NIRS provides data with richer information content, which complements or exceeds the capabilities of CW-NIRS. One example is the ability of FD-NIRS to measure the absolute optical properties (absorption and reduced scattering coefficients) of tissue, and thus the absolute concentrations of oxyhemoglobin and deoxyhemoglobin in brain tissue. This article reviews the measured values of such optical properties and hemoglobin concentrations reported in the literature for animal models and for the human brain in newborns, infants, children, and adults. We also review the application of FD-NIRS to functional brain studies that focused on slower hemodynamic responses to brain activity (time scale of seconds) and faster optical signals that have been linked to neuronal activation (time scale of 100 ms). Another example of the power of FD-NIRS data is related to the different regions of sensitivity featured by intensity and phase data. We report recent developments that take advantage of this feature to maximize the sensitivity of non-invasive optical signals to brain tissue relative to more superficial extracerebral tissue (scalp, skull, etc.). We contend that this latter capability is a highly appealing quality of FD-NIRS, which complements absolute optical measurements and may result in significant advances in the field of non-invasive optical sensing of the brain.

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Healthy term and moderately preterm infants have similar cerebral oxygen saturation and cerebral blood flow volumes during early post‐natal transition

Abstract: Our findings suggest that during the first three days after birth there was adequate cardiorespiratory adaptation, cerebral perfusion and adequate compensation through the arterial circle of Willis in both healthy term and moderately preterm infants.

Cited by 9 publications

References 31 publications

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Prospective observational study on assessing the hemodynamic relevance of patent ductus arteriosus with frequency domain near-infrared spectroscopy

Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy

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