Hearing Aid Use Status and All-Cause and Cause-Specific Dementia and the Roles of Mediators and Moderators: A Prospective Analysis of UK Biobank Data

Jiang, Fan; Mishra, Shiva Raj; Shrestha, Nipun; Ozaki, Akihiko; Virani, Salim S.; Bright, Tess; Kuper, Hannah; Zhou, Chengchao; Zhu, Dongshan

doi:10.2139/ssrn.4277511

Cited by 15 publications

(25 citation statements)

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“…The ACHIEVE research has also confirmed that one or more ways of hearing intervention can improve the impact of hearing loss on cognitive impairment 16 . Multiple studies by the UK's Biobank also support the mechanisms underlying these associations 47,48 . Multimodal interventions provide strong evidence for delaying the rate of cognitive decline 11 .…”

Section: Discussionmentioning

confidence: 92%

“…However, previous studies have shown that sensory impairment is a new modifiable risk factor for cognitive function, including dementia, memory, and mental state, with significant clinical and public health implications 11,15–18,46 . Biobank UK recruited 437,704 participants from 22 centers and found that correcting hearing can prevent 8% of dementia cases 47 . Emphasizing that hearing aids are a minimally invasive and cost‐effective intervention measure that can effectively reduce the impact of HI on cognitive decline and dementia 47 .…”

Section: Discussionmentioning

confidence: 99%

“…Biobank UK recruited 437,704 participants from 22 centers and found that correcting hearing can prevent 8% of dementia cases 47 . Emphasizing that hearing aids are a minimally invasive and cost‐effective intervention measure that can effectively reduce the impact of HI on cognitive decline and dementia 47 . The longitudinal aging survey joint model, which included three representative national cohorts, also found similar findings that HI and/or VI are a sign of cognitive decline, with respondents with dual sensory impairment having a more severe impact 48 .…”

Section: Discussionmentioning

confidence: 99%

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Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses

Liang,

Zheng

et al. 2024

Int J Geriat Psychiatry

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BackgroundDementia is associated with individual vision impairment (VI) and hearing impairment (HI). However, little is known about their associations with motoric cognitive risk syndrome (MCR), a pre‐dementia stage. We investigated the association of VI, HI, and dual sensory impairment (DSI) with MCR and to further evaluate causal relationships using Mendelian randomization (MR) approach.MethodsFirst, an observational study was conducted in the China Health and Retirement Longitudinal Study (CHARLS). Evaluate the cross‐sectional and longitudinal associations of VI, HI, and DSI with MCR using the logistic regression models and Cox proportional hazard models, respectively. Second, evaluate the causal association between VI and HI with MCR using MR analysis. The GWAS data was used for genetic instruments, including 88,250 of European ancestry (43,877 cases and 44,373 controls) and 504,307 with “white British” ancestry (100,234 cases and 404,073 controls), respectively; MCR information was obtained from the GWAS with 22,593 individuals. Inverse variance weighted was the primary method and sensitivity analysis was used to evaluate the robustness of MR methods.ResultsIn the observational study, VI (HR: 1.767, 95%CI: 1.331–2.346; p < 0.001), HI (HR: 1.461, 95%CI: 1.196–1.783; p < 0.001), and DSI (HR: 1.507, 95%CI: 1.245–1.823; p < 0.001) were significantly associated with increased risk of MCR. For the MR, no causal relationship between VI (OR: 0.902, 95% CI: 0.593–1.372; p = 0.631) and HI (OR: 1.016, 95% CI: 0.989–1.043; p = 0.248) with MCR risk, which is consistent with the sensitivity analysis.ConclusionVI, HI, and DSI were significantly associated with MCR, but MR analysis failed to provide evidence of their causal relationship. Emphasized the importance of sensory impairment screening in identifying high‐risk populations for dementia.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses

Liang,

Zheng

et al. 2024

Int J Geriat Psychiatry

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“…While research in humans informs understanding of PL, additional foundational knowledge has come from research in nonhuman animal models. Recording from individual neurons in nonhuman primates shows PL changes response properties of neurons at different stages of visual processing, including primary visual cortex (V1, Schoups et al, 2001), extrastriate visual cortex (medial superior temporal area (MST), Gu et al, 2011; V4, Yang & Maunsell, 2004), and even prefrontal cortex (Jing et al, 2021). Thus, PL helps explain how multiple regions across the brain learn together as a network (Maniglia & Seitz, 2018).…”

Section: Animal Models Provide Foundational Mechanistic Knowledgementioning

confidence: 99%

Perceptual Learning: Policy Insights From Basic Research to Real-World Applications

Seitz,

Sekuler,

Dosher

et al. 2023

Policy Insights from the Behavioral and Brain Sciences

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Perceptual learning is the process by which experience alters how incoming sensory information is processed by the brain to give rise to behavior—it is critical for how humans educate children, train experts, treat diseases, and promote health and well-being throughout the lifespan. Knowledge of perceptual learning requires basic and applied research in humans and nonhuman animal models, which informs strategic targets for advancing applications. Commercial products to induce perceptual learning are proliferating rapidly with limited regulation (e.g., for rehabilitation), while at the same time basic science is increasingly restricted by changing regulations (such as new granting-agency definitions of clinical trials). Realizing the full potential of perceptual learning requires balancing basic and translational science to advance new knowledge, while serving and protecting consumers. Reforms can promote open, accessible, and representative research, and the translation of this research to applications across different sectors of society.

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“…Jiang, Mishra, Shrestha, et al (2023) 20 reported in The Lancet that the UK Biobank population-based study of some 437,000 adults (ages 40–69 years) compared people without hearing loss to unaided people with hearing loss. They report the unaided people with hearing loss had as increased risk of all-cause dementia, yet people with hearing loss who wore hearing aids demonstrated no increased dementia risk.…”

Section: Hearing Aid Amplification and Social Engagementmentioning

confidence: 99%

Audition, Amplification, and Social Engagement

Beck

2023

The Hearing Journal

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PersPectives With Dr. Beck O berlin College (2023) 1 reports that humans are essentially group-oriented social beings. We typically live in families, we participate in social media, small and large groups, teams at school, work, hobbies, worship and fellowship services, music, politics, professions, economic alliances, politics, and more. They report, "Our norms are shaped by our culture, itself an emergent property of group-living. " As such, social engagement is an important, dominant, and pivotal factor in our daily lives.During the recent COVID-19 pandemic, people were urged to stay home, to not visit, to not participate in groups, and to avoid social contact. Although these cautions and realities helped slow and attenuate the spread of COVID-19, social isolation, anxiety, and loneliness increased, with anticipated concomitant results.Osborne (2023) 2 reports that 34 years ago, in 1990, 27% of adults had three or fewer friends. That is not a lot! Unfortunately, in 2021, 49% reported having three or fewer friends. Likewise, in 2003, young people (ages 15-24 years) spent 2.5 hours per day with in-person friends. By 2020, it was less than 40 minutes per day.Social engagement impacts our quality of life and communication disorders present substantial barriers to social engagement. When hearing and listening disorders are suspected, diagnosed, and treated early, they can most often be successfully managed by hearing care professionals working in tandem with the patient.

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Hearing Aid Use Status and All-Cause and Cause-Specific Dementia and the Roles of Mediators and Moderators: A Prospective Analysis of UK Biobank Data

Cited by 15 publications

References 0 publications

Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses

Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses

Perceptual Learning: Policy Insights From Basic Research to Real-World Applications

Audition, Amplification, and Social Engagement

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