Hearing and vestibular disorders in patients with systemic lupus erythematosus

Batuecas‐Caletrío, Ángel; Pino‐Montes, Javier del; Cordero-Civantos, Cristina; Calle-Cabanillas, MI; Lopez-Escamez, José A.

doi:10.1177/0961203313477223

Cited by 38 publications

(15 citation statements)

References 25 publications

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“…The vestibular system could be involved in SLE, but vertigo and dizziness have rarely been reported [35, 36]. Balance disorders as a consequence of SLE have been observed also in children [37]; however, the incidence of vestibular symptoms may be underestimated due to their slowly progressive onset and consequent compensation by the somatosensory system and vision.…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

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Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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“…Systemic lupus erythematosus (SLE), a chronic inflammatory autoimmune disease, affects numerous organs and systems, including the skin, joints, lungs, and kidneys. Ear findings are not included in the diagnostic criteria, but SLE is associated with sensorineural hearing loss, tinnitus, and vestibular disorders (1,2). Vestibular symptoms are common in patients with SLE: one questionnaire-based study found that their frequency of audiovestibular symptoms, including vertigo, was significantly higher than in healthy control patients (3,4).…”

Section: Resultsmentioning

confidence: 99%

Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus

Kariya

Hızlı

Kaya

et al. 2015

Otology &Amp; Neurotology

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“…However, sensorineural hearing loss and tinnitus are associated with SLE (2). Inner ear dysfunction is frequently detected in both adult and pediatric SLE patients (3–5).…”

Section: Introductionmentioning

confidence: 99%

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

Kariya¹,

Kaya

Hızlı

et al. 2016

Otology &Amp; Neurotology

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Hypothesis We hypothesized that, in archived human temporal bone samples from patients with systemic lupus erythematosus (SLE), a pathologic condition exists in the stria vascularis and cochlear hair cells. Background Sensorineural hearing loss is a common feature in SLE patients. However, the pathophysiologic mechanism of cochlear dysfunction is unclear. Methods We examined 15 temporal bone samples from 8 SLE patients, along with 17 samples from 10 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. We determined the area of the stria vascularis in a midmodiolar section of each cochlear turn. Then, we made cytocochleograms and calculated the percentage of missing inner and outer hair cells. Results The area of the stria vascularis in our SLE group was significantly smaller than in our control group. The number of remaining inner hair cells in our SLE group was smaller than in our control group; however, the difference did not reach statistical significance. The loss of outer hair cells in our SLE group was significantly higher than in our control group. There was a tendency toward a positive correlation between the loss of cochlear hair cells and the duration of SLE. Conclusion The stria vascularis and cochlear hair cells are affected in SLE patients. Our findings could provide the histopathologic basis for the cochlear dysfunction, including sensorineural hearing loss, experienced by SLE patients.

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Hearing and vestibular disorders in patients with systemic lupus erythematosus

Abstract: Migraine, SNHL and episodic vertigo are comorbid conditions in patients with SLE, but migraine is not associated with SNHL or vertigo in these patients. However, SNHL and vertigo are associated conditions in SLE, suggesting a common audiovestibular dysfunction.

Cited by 38 publications

References 25 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

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