Hearing Evaluation of Neonates with Hyperbilirubinemia by Otoacoustic Emissions and Brain Stem Evoked Response Audiometry

Mirajkar, Swapnil Chandrakant; Rajadhyaksha, Surekha

doi:10.3126/jnps.v36i3.12155

Cited by 2 publications

(7 citation statements)

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“…13, 28 Furthermore, preterm infants with TSB levels equal to or above 14 mg/dl have been reported to have a higher risk of deafness. 20 Mirajkar and Rajadhyaksha 15 also found persistent abnormal ABR in infants who retrospectively had TSB levels between 12 and 15 mg/dl when they were screened before 3 months of age, whereas none of those with TSB levels above 25 mg/dl had abnormal ABR findings at follow-up. Since it may be difficult to eliminate all other risk factors for hearing loss in hospitalized newborns with hyperbilirubinemia, as seen in our study, the foregoing suggests that hyperbilirubinemia alone may not be responsible for the hearing test abnormalities observed, as opined by some authors.…”

Section: Discussionmentioning

confidence: 90%

“…Similarly, persistent brainstem auditory evoked response (BAER) abnormalities were reported among term newborns with TSB less than 15 mg/dl. 14, 15 These reports suggest that the specific bilirubin level at which hearing becomes impaired is ill-defined. Furthermore, in 2015, Corujo-Santana et al 16 reported hearing loss in 13 preterm and two term newborns with bilirubin levels of 5−13.99 mg/dl, while 11 preterm and five term newborns had hearing loss at bilirubin levels of 14 to 19.99 mg/dl.…”

Section: Introductionmentioning

confidence: 99%

“…Despite these findings, screening for hearing loss has been recommended at bilirubin levels higher than 20 mg/dl or 1% of birth weight. 17 Overall, some studies reported an incidence of hearing loss at bilirubin levels at and above the ETT range 18,19 while others found a high risk of deafness at TSB levels below 20 mg/dl 15,20 among term and preterm infants. This raises the question of at what TSB level hearing becomes impaired.…”

Section: Introductionmentioning

confidence: 99%

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Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Oyinwola

Mukhtar-Yola

Olusesi

et al. 2023

Journal of Neonatology

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Objective To determine the total serum bilirubin (TSB) cut-off value predictive of hearing impairment among newborns with hyperbilirubinemia at the National Hospital Abuja. Setting This was a cross-sectional study conducted in the Special Care Baby Unit (SCBU) and Neonatal Intensive Care Unit (NICU) of National Hospital Abuja between August 2020 and February 2021. Methods A universal sampling of eligible participants was done, and consent was obtained from the parent. Using the TSB and results of hearing screening carried out with the Otoport advance from Otodynamics®, the proportion of automated auditory brainstem response (AABR) screening failure was determined, and the receiver’s operating characteristics (ROC) curve coordinates were used to find the threshold bilirubin level for the risk of hearing loss. The Spearman-Rho correlation assessed the relationship between TSB level and AABR findings. Results 160 newborns below 28 days of age, delivered at 34 weeks gestation and above, who had clinical jaundice were recruited. The prevalence of screening AABR failure in at least one ear was 26.2%. The correlation between TSB and AABR was weakly positive (rs = .189, p = .093) and the TSB cut-off for AABR failure was 16.3 mg/dl (sensitivity 45.5%, specificity 81%, Youden’s-J statistic = 0.265). Conclusion The TSB threshold for AABR screening failure was 16.3 mg/dl, but TSB did not correlate well with screening AABR. Serum bilirubin above 15 mg/dl in late preterm and term neonates should be actively treated with phototherapy and/or exchange blood transfusions where feasible, particularly in resource-poor settings.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Oyinwola

Mukhtar-Yola

Olusesi

et al. 2023

Journal of Neonatology

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“…For comparison, eight studies reported aBAERS among neonates admitted with jaundice (Figure 7). [6,33,34,39,45,64,87,89,91].…”

Section: Resultsmentioning

confidence: 99%

“…The funnel plot appeared largely asymmetrical (Figure 8) with empirical evidence supporting this observation (Begg test p < 0.001, Egger's bias = 13.0, p < 0.001). [6,33,34,39,45,64,87,89,91].…”

Section: Resultsmentioning

confidence: 99%

Global Prevalence of Severe Neonatal Jaundice among Hospital Admissions: A Systematic Review and Meta-Analysis

Diala

Usman

Appiah

et al. 2023

JCM

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Evidence regarding the adverse burden of severe neonatal jaundice (SNJ) in hospitalized neonates in resource-constrained settings is sparse. We attempted to determine the prevalence of SNJ, described using clinical outcome markers, in all World Health Organization (WHO) regions in the world. Data were sourced from Ovid Medline, Ovid Embase, Cochrane Library, African Journals Online, and Global Index Medicus. Hospital-based studies, including the total number of neonatal admissions with at least one clinical outcome marker of SNJ, defined as acute bilirubin encephalopathy (ABE), exchange blood transfusions (EBT), jaundice-related death, or abnormal brainstem audio-evoked response (aBAER), were independently reviewed for inclusion in this meta-analysis. Of 84 articles, 64 (76.19%) were from low- and lower-middle-income countries (LMICs), and 14.26% of the represented neonates with jaundice in these studies had SNJ. The prevelance of SNJ among all admitted neonates varied across WHO regions, ranging from 0.73 to 3.34%. Among all neonatal admissions, SNJ clinical outcome markers for EBT ranged from 0.74 to 3.81%, with the highest percentage observed in the African and South-East Asian regions; ABE ranged from 0.16 to 2.75%, with the highest percentages observed in the African and Eastern Mediterranean regions; and jaundice-related deaths ranged from 0 to 1.49%, with the highest percentage observed in the African and Eastern Mediterranean regions. Among the cohort of neonates with jaundice, the prevalence of SNJ ranged from 8.31 to 31.49%, with the highest percentage observed in the African region; EBT ranged from 9.76 to 28.97%, with the highest percentages reported for the African region; ABE was highest in the Eastern Mediterranean (22.73%) and African regions (14.51%). Jaundice-related deaths were 13.02%, 7.52%, 2.01% and 0.07%, respectively, in the Eastern Mediterranean, African, South-East Asian and European regions, with none reported in the Americas. aBAER numbers were too small, and the Western Pacific region was represented by only one study, limiting the ability to make regional comparisons. The global burden of SNJ in hospitalized neonates remains high, causing substantial, preventable morbidity and mortality especially in LMICs.

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Hearing Evaluation of Neonates with Hyperbilirubinemia by Otoacoustic Emissions and Brain Stem Evoked Response Audiometry

Abstract: Introduction: Neonatal hyperbilirubinemia is one of the most

Cited by 2 publications

References 2 publications

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Threshold and Correlation of Total Serum Bilirubin with Screening Automated Auditory Brainstem Response Among Newborns with Hyperbilirubinemia in National Hospital Abuja

Global Prevalence of Severe Neonatal Jaundice among Hospital Admissions: A Systematic Review and Meta-Analysis

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