“…Ten individuals had disorders of organelle biogenesis, dynamics and interactions, five neurotransmitter disorders, two congenital disorders of glycosylation (CDG), two disorders of mitochondrial cofactor biosynthesis, one disorder of mitochondrial DNA maintenance and replication, and one disorder of amino acid metabolism ( Table 1 ). Five individuals have already been published in the literature [21] , [22] , [23] , [24] . Eight of the 17 IMDs did not have known specific biomarkers ( DNML1, ADCK3, ALDH18A1, ST3GAL5, SLC13A5, SLC6A1, NGLY1, PIGN ), although two of them display non-specific elevated lactates ( DNML1, ADCK3 ).…”