Hearing Impairment, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Cohort Studies

Wei, Jingkai; Hu, Yirui; Zhang, Li; Hao, Qiang; Yang, Ruowei; Lu, Haidong; Zhang, Xuan; Chandrasekar, Eeshwar K.

doi:10.1159/000485178

Cited by 81 publications

(67 citation statements)

References 38 publications

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“…This finding is in line with the results of the present analysis. Due to the larger sample size in our analysis, the confidence interval of our analysis was smaller and, thus, our results are more precise (Wei et al, 2017;Loughrey et al, 2018).…”

Section: Discussionmentioning

confidence: 79%

“…Previous evidence has shown that hearing impairment is associated with a decrease in cognition and a higher risk of dementia diseases. The meta-analysis of Wei et al (2017) aggregated data on more than 15,000 subjects from different cohort studies, revealing that hearing loss was associated with a greater risk for cognitive impairment (RR 1.3, CI 95% 1.12-1.51) and dementia (RR 2.4, CI 95% 1.58-3.61). This was confirmed in a second meta-analysis recently published by Loughrey et al (2018) aggregating different cohort and cross-sectional studies.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Hearing and Vision Impairment and Risk of Dementia: Results of a Case-Control Study Based on Secondary Data

Michalowsky

Hoffmann

Kostev³

2019

Front. Aging Neurosci.

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Introduction: Hearing and vision loss are highly prevalent in elderly adults, and thus frequently occur in conjunction with cognitive impairments. Studies have shown that hearing impairment is associated with a higher risk of dementia. However, evidence concerning the association between vision loss and dementia, as well as the co-occurrence of vision and hearing loss and dementia, has been inconclusive. Objectives: To assess the association between: (i) either hearing or vision loss and the risk of dementia, as well as between; and (ii) the combination of both sensory impairments and the risk of dementia. Methods: This case-control study was based on a 5-year data set that included patients aged 65 years and older who had initially been diagnosed with dementia diseases by one of 1,203 general practitioners in Germany between January 2013 and December 2017. In total, 61,354 identified dementia cases were matched to non-dementia controls, resulting in a sample size of 122,708 individuals. Hearing loss and vision loss were identified using the ICD-10 diagnoses documented in the general practitioners' files prior to the initial dementia diagnosis. Multivariate logistic regression models were fitted to evaluate the associations between visual and/or hearing impairment and the risk of dementia and controlled for sociodemographic and clinical variables. Results: Hearing impairment was documented in 11.2% of patients with a dementia diagnosis and 9.5% of patients without such a diagnosis. Some form of vision impairment was documented in 28.4% of patients diagnosed with dementia and 28.8% of controls. Visual impairment was not significantly associated with dementia (OR = 0.97, CI = 95% 0.97-1.02, p = 0.219). However, patients with hearing impairment were at

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Association Between Hearing and Vision Impairment and Risk of Dementia: Results of a Case-Control Study Based on Secondary Data

Michalowsky

Hoffmann

Kostev³

2019

Front. Aging Neurosci.

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“…One of the most significant developments in our knowledge of ARHL etiology over the last decade has been the emergence of hearing loss as a risk factor for developing dementia. A large number of studies have found a link between ARHL and cognitive decline, dementia, and Alzheimer's disease with the hearing loss predating and predicting subsequent clinical diagnosis of dementia Gurgel et al 2014;Wei et al 2017;Jayakody et al 2018). There are several possible explanations for this association between the two morbidities and the resulting implications for our understanding of the mechanisms underlying the two diseases.…”

Section: Arhl and Dementiamentioning

confidence: 99%

Age-Related Hearing Loss

Bowl

Dawson

2018

Cold Spring Harb Perspect Med

244

160

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Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate agerelated auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.

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“…ARHI is characterised by a non-syndromic bilateral, sensorineural hearing loss that progresses with increasing age and is an established risk factor for depression [6][7][8] and dementia [9][10][11][12] . Hearing loss was ranked fourth in the latest study into the Global Burden of Diseases 13 , yet hearing amplification devices are the only treatment option currently available for ARHI.…”

Section: Age-related Hearing Impairment (Arhi) Is the Most Common Senmentioning

confidence: 99%

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

Wells

Freidin

Abidin

et al. 2019

Preprint

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# Joint senior authors *Corresponding authors 2 Age-related hearing impairment (ARHI) is the most common sensory impairment in the aging population; a third of individuals are affected by disabling hearing loss by the age of 65 1 . ARHI is a multifactorial condition caused by both genetic and environmental factors, with estimates of heritability between 35% and 55% [2][3][4] . The genetic risk factors and underlying biological pathology of ARHI are largely unknown, meaning that targets for new therapies remain elusive.We performed genome-wide association studies (GWAS) for two self-reported hearing phenotypes, hearing difficulty (HDiff) and hearing aid use (HAid), using over 250,000 UK Biobank 5 volunteers aged between 40-69 years. We identified 44 independent genome-wide significant loci (P<5E-08), 33 of which have not previously been associated with any form of hearing loss. Gene sets from these loci are enriched in auditory processes such as synaptic activities, nervous system processes, inner ear morphology and cognition. Immunohistochemistry for protein localisation in adult mouse cochlea indicate metabolic, sensory and neuronal functions for NID2, CLRN2 and ARHGEF28 identified in the GWAS. These results provide new insight into the genetic landscape underlying susceptibility to ARHI.ARHI is characterised by a non-syndromic bilateral, sensorineural hearing loss that progresses with increasing age and is an established risk factor for depression 6-8 and dementia 9-12 . Hearing loss was ranked fourth in the latest study into the Global Burden of Diseases 13 , yet hearing amplification devices are the only treatment option currently available for ARHI. ARHI is expected to be a highly genetically heterogeneous trait given that over 150 genetic loci have been identified in non-syndromic hereditary hearing loss alone (https://hereditaryhearingloss.org/). Previous GWAS of ARHI have identified a small number of promising candidate genes, though there has been poor replication of findings to date, possibly reflecting varied phenotyping approaches and limited sample sizes 14-24 .We conducted two GWAS using the self-reported hearing difficulty and hearing aid use of UK Biobank (UKBB) participants and refined our results using a combination of conditional analysis, replication analysis, in silico annotation and in vivo expression analysis (see Figure 1 for study design). Our aim was to identify the genetic components of adult hearing impairment in the UK population and provide insight into the pathology of ARHI.3 UKBB participants were categorised using a case-control design based on responses to questions regarding hearing difficulty (HDiff, n=498,281) and hearing aid use (HAid, n=316,629) ( Supplementary Figure 1). A linear mixed-effects model was used to test for association between 9,740,198 SNPs and the two traits, using BOLT-LMM v.2 25 , which corrects for population stratification and within sample relatedness. Following additional quality control filters and selection of white British participants (described ...

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Hearing Impairment, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Cohort Studies

Cited by 81 publications

References 38 publications

Association Between Hearing and Vision Impairment and Risk of Dementia: Results of a Case-Control Study Based on Secondary Data

Association Between Hearing and Vision Impairment and Risk of Dementia: Results of a Case-Control Study Based on Secondary Data

Age-Related Hearing Loss

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

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