Hearing loss caused by discoid lupus erythematosus of the ear canal successfully treated with hydroxychloroquine

Multiple Comedonal Plaques of Both Ears With Hearing Loss: Answer

“…In these patients, the mechanism is mostly of conductive type, probably related to the presence of DLE lesions within the ear canal. 5 Treatment by steroids, hydroxychloroquine, and/or immunosuppressive drugs improves not only the cutaneous manifestations but also both the sensorineural and conductive hearing loss. 4 A clinical presentation similar to that observed in our patient has been reported also under the term of comedonal or comedogenic lupus erythematosus (LE).…”

“…4,5 The mechanism of inner ear damage remains unclear, but could be related to microinfarctions after thrombosis in the inner ear. 5 The exact frequency of hearing loss in patients with DLE is not known. In these patients, the mechanism is mostly of conductive type, probably related to the presence of DLE lesions within the ear canal.…”

“…4 A variable percentage of SLE patients (11%-66%) presents with hearing loss, mostly of the sensorineural type. 4,5 The mechanism of inner ear damage remains unclear, but could be related to microinfarctions after thrombosis in the inner ear. 5 The exact frequency of hearing loss in patients with DLE is not known.…”

“…In these patients, the mechanism is mostly of conductive type, probably related to the presence of DLE lesions within the ear canal. 5 Treatment by steroids, hydroxychloroquine, and/or immunosuppressive drugs improves not only the cutaneous manifestations but also both the sensorineural and conductive hearing loss. 4…”

Relação entre ototoxicidade e uso de Hidroxicloroquina em pacientes com lúpus eritematoso sistêmico

“…Esta medicação foi a utilizada por 65,7% dos sujeitos com LES do estudo analisado, fazendo parte do tratamento de 80% dos pacientes com perda auditiva. Esta droga também foi utilizada em larga escala no tratamento de pacientes com LES em outros estudos compilados na literatura [32][33][34] .…”