Hearing Loss in Adults in Older Age Groups

Golovanova, L. E.; Boboshko, M. Yu.; Kvasov, E. A.; Lapteva, E S

doi:10.1134/s2079057019040064

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…The inclusion criteria were normal findings on otoscopic examination, presence of pure-tone audiometry data, and an age of 40–79 years. We excluded individuals who showed a difference of > 30 dB HL in the bilateral pure-tone threshold since ARHL is typically associated with symmetric hearing impairment 4 , 44 . Individuals with missing values regarding any candidate risk factor [age, sex, HTN, diabetes, dyslipidemia, stroke, CVD, occupational noise exposure, smoking history, and body mass index (BMI)] were also excluded (see Supplementary Figure S1 online).…”

Section: Methodsmentioning

confidence: 99%

Synergistic effect of smoking on age-related hearing loss in patients with diabetes

Bae

Kwak

Choi

et al. 2020

Sci Rep

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This study investigated the synergistic effects of risk factors on age-related hearing loss (ARHL) using nationwide cross-sectional data of 33,552 individuals from the 2010‒2013 Korea National Health and Nutrition Examination Survey. Patients with ARHL were selected based on their pure-tone audiometry results. Previously reported risk factors for ARHL were analyzed using logistic regression and propensity score-matching, and synergistic effects between risk factors were analyzed using propensity score-matching. Of the 12,570 individuals aged 40–79 years, 2002 (15.9%) met the criteria for ARHL. Male sex, exposure to occupational noise, and diabetes showed a significant relationship with ARHL (p < 0.05) in both the logistic regression and propensity score-matching analyses. Smoking and diabetes showed the strongest significant synergistic effect on ARHL (odds ratio [OR] 1.963, 95% confidence interval [CI] 1.285‒2.998; p = 0.002). In the subgroup analysis based on smoking status, current smokers with diabetes had a significant relationship with ARHL (OR 1.883, CI 1.191‒2.975; p = 0.009), whereas ex-smokers with diabetes did not (OR 1.250; CI 0.880‒1.775; p = 0.246). This implies that current smokers with diabetes may benefit from the cessation of smoking. In conclusion, patients with diabetes should strictly avoid or cease smoking to prevent the progression of ARHL.

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Section: Methodsmentioning

confidence: 99%

Synergistic effect of smoking on age-related hearing loss in patients with diabetes

Bae

Kwak

Choi

et al. 2020

Sci Rep

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“…Stach et al revealed CAPD symptoms in 70% of adults older than 60 years of age, and its occurrence increases with aging: adults of 50-54 years old had CAPD in 17% of cases; meanwhile, adults older than 80 years old had CAPD in 95% of cases [37]. According to Golovanova et al, 31% of elderly patients with normal hearing thresholds complained of hearing impairment, which was explained by the authors as impaired speech intelligibility caused by central auditory pathway dysfunction [38]. Australian investigators, Golding et al, also confirm the increase of CAPD occurrence associated with aging and note the prevalence of men with this pathology [39].…”

Section: The Evaluation Of Central Auditory Pathwaysmentioning

confidence: 99%

Characteristics of Hearing in Elderly People

Boboshko¹,

Zhilinskaya²,

Maltseva³

2018

Gerontology

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The authors define the term presbycusis and discuss the prevalence of hearing loss in elderly people, its etiology, and methods of diagnostics (anamnesis, evaluation of the peripheral and central parts of the hearing system). The authors emphasize that central auditory processing disorder (CAPD) significantly impairs speech perception in elderly people and makes difficult the rehabilitation of patients with presbycusis. The possibility of improving speech intelligibility by using auditory training is considered. Improved functioning of the central auditory pathways in hearing aid (HA) users with moderate to moderately severe chronic sensorineural hearing loss (SNHL) and symptoms of CAPD was shown after the auditory training with the use of two approaches ("bottom-up" and "top-down"). The algorithm of the auditory training was designed based on distinction between nonverbal and verbal stimuli of varying complexity, as well as tasks to improve memory (e.g., memorizing poetry). The benefits of the auditory training in the rehabilitation of HA users with low speech intelligibility were demonstrated. Improvement of speech intelligibility in elderly patients with SNHL proves that plasticity of the auditory regions of the brain remains possible throughout the life. Options of the presbycusis prophylaxis are summarized.Different authors sometimes interpret this term differently. Some researchers meant (imply under this term) age-related hearing disorders caused by involutional changes only in the cochlea, and others meant that changes involve all parts of the auditory system [1,2]. Presbycusis is considered to be one of the forms of progressive SNHL, which is associated with age-related involutional changes of different parts of the hearing system and is presented by symmetric pure tone audiogram with flat loss toward high-frequency range (less steep than 20 dB/oct) [3]. Numerous studies are dedicated to anatomical and functional risk factors of the presbycusis [4][5][6][7][8][9]. The significance of the presbycusis problem is determined by its social importance, lack of data about its etiology, and need for clinical practice to accurately determine an impaired area of auditory system and to identify the presbycusis genesis. PrevalencePresbycusis is a rather common disorder. According to the World Health Organization (WHO), more than 5% of global population (about 328 millions of adults) suffers from any degree of hearing loss, while among people older than 65 years of age, the prevalence of hearing loss exceeds 30% [10].Its prevalence increases every year that may be due to the general trend of increased life duration-much more adults reach aged (from 60 to 74 years old according to the WHO classification) and senile (75 years old and more) periods. The world population is rapidly aging. At the period between 2000 and 2050, the proportion of the world's population over 60 years will double from about 11 to 22%. The absolute number of people aged 60 years and over is expected to increase from 605 million to 2 billion ov...

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“…Age-related hearing loss (AHL), or presbycusis, is a major sensory impairment [1] generally caused by the degeneration of hair cells within the organ of Corti [2]. AHL is characterized by a slow progressive decline in hearing sensitivity and balance [3].…”

Section: Introductionmentioning

confidence: 99%

An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice

Zheng

Kui

et al. 2020

Neural Plasticity

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Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function—protective genes that confer strong resistance to hearing loss. Previously, we reported that C57BL/6J (B6) and DBA/2J (D2) strains share a common hearing loss allele in Cdh23. The cadherin 23 (Cdh23) gene is a key contributor to early-onset hearing loss in humans. In this study, we tested hearing across a large family of 54 BXD strains generated from B6 to D2 crosses. Five of 54 strains maintain the normal threshold (20 dB SPL) even at 2 years old—an age at which both parental strains are essentially deaf. Further analyses revealed an age-related hearing protection (ahp) locus on chromosome 16 (Chr 16) at 57~76 Mb with a maximum LOD of 5.7. A small number of BXD strains at 2 years with good hearing correspond roughly to the percentage of humans who have good hearing at 90 years old. Further studies to define candidate genes in the ahp locus and related molecular mechanisms involved in age-related resilience or resistance to AHL are warranted.

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Hearing Loss in Adults in Older Age Groups

Cited by 3 publications

References 37 publications

Synergistic effect of smoking on age-related hearing loss in patients with diabetes

Synergistic effect of smoking on age-related hearing loss in patients with diabetes

Characteristics of Hearing in Elderly People

An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice

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