Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta‐Analysis

Shih, Michael C.; Gordis, Tamar M.; Lambert, Paul R.; Nguyen, Shaun A.; Meyer, Ted A.

doi:10.1002/lary.30384

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…It may be interesting to assess whether there is a correlation between visual, cognitive, and olfactory function. Furthermore, recent works have correlated pseudoexfoliation syndrome with neurosensory hearing loss [72] and possibly glaucoma [73]. These data suggest that PXS may correlate with multisensory impairment (hyposmia, glaucoma, and hearing loss), opening the possibility of a multidisciplinary approach to screening for sense-organ disorders, which would likely have a positive impact on the quality of life of these patients.…”

Section: Discussionmentioning

confidence: 72%

Olfactory Dysfunction and Glaucoma

Iannucci,

Bruscolini,

Iannella

et al. 2024

Biomedicines

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Background: Olfactory dysfunction is a well-known phenomenon in neurological diseases with anosmia and hyposmia serving as clinical or preclinical indicators of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. Since glaucoma is a neurodegenerative disease of the visual system, it may also entail alterations in olfactory function, warranting investigation into potential sensory interconnections. Methods: A review of the current literature of the last 15 years (from 1 April 2008 to 1 April 2023) was conducted by two different authors searching for topics related to olfaction and glaucoma. Results: three papers met the selection criteria. According to these findings, patients with POAG appear to have worse olfaction than healthy subjects. Furthermore, certain predisposing conditions to glaucoma, such as pseudoexfoliation syndrome and primary vascular dysregulation, could possibly induce olfactory changes that can be measured with the Sniffin Stick test. Conclusions: the scientific literature on this topic is very limited, and the pathogenesis of olfactory changes in glaucoma is not clear. However, if the results of these studies are confirmed by further research, olfactory testing may be a non-invasive tool to assist clinicians in the early diagnosis of glaucoma.

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Section: Discussionmentioning

confidence: 72%

Olfactory Dysfunction and Glaucoma

Iannucci,

Bruscolini,

Iannella

et al. 2024

Biomedicines

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Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Xu,

Liao,

Zhang

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveWe aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence.Data SourcesEmbase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023.Review MethodsWe included meta‐analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers. We calculated summary effect estimates, 95% confidence interval, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases.ResultsOf the 9211 articles retrieved, 60 eligible articles were included. The 60 eligible articles identified 47 potential environmental risk and protective factors (N = 4,123,803) and 46 potential biomarkers (N = 173,701). Evidence of association was convincing (class I) for rheumatoid arthritis (RA) and every 1 cm increase in height. Evidence of association was highly suggestive (class II) for human immunodeficiency virus (HIV), diabetes, cumulative noise exposure (CNE), smoking, congenital cytomegalovirus (CMV) infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and alopecia areata (AA).ConclusionIn this umbrella review, RA, every 1 cm increase in height, HIV, diabetes, CNE, smoking, congenital CMV infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and AA were strongly associated with HL.

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Beyond the Dusty Fog: Local Eye Drop Therapy and Potentially New Treatment Alternatives in Pseudoexfoliative Glaucoma

Zeppieri,

Musa

2024

CMC

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Pseudoexfoliative glaucoma (PEG) is a type of secondary open-angle glaucoma characterized by the accumulation of whitish-gray material on the trabecular meshwork and lens, leading to an increase in intraocular pressure (IOP) and optic nerve damage. Local eye drop therapy is one of the first-line treatments for PEG, which include prostaglandin analogues, beta-blockers, and alpha-adrenergic agonists to lower IOP. New treatments beyond conventional techniques, however, are constantly being developed. One potential treatment proposed for PEG is based on magnetic phage display, which involves using magnetic nanoparticles conjugated to specific peptides or proteins selected using phage display techniques to remove aggregates in the anterior chamber of the eye or inflammatory cells and cytokines that contribute to PEG pathogenesis. Other potential treatments include microRNAs (miRNAs) that are involved in the regulation of gene expression at the post-transcription stages. Gene therapies, nanotechnology, immunotherapy and methods based on stem cells can also be potentially used to target and treat specific tissues and cells responsible for regulating IOP. In addition, photobiomodulation therapy (PBMT), a non-invasive procedure that utilizes low-level laser therapy to improve cellular function and promote tissue repair, can prove an interesting alternative in treating PEG. The aim of our mini-review is to provide a brief overview of these innovative methods that appear to offer potentially promising treatment options for PEG.

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Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta‐Analysis

Cited by 3 publications

References 72 publications

Olfactory Dysfunction and Glaucoma

Olfactory Dysfunction and Glaucoma

Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Beyond the Dusty Fog: Local Eye Drop Therapy and Potentially New Treatment Alternatives in Pseudoexfoliative Glaucoma

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