Hearing loss in neonates and infants

Choe, Goun; Park, Su Kyoung; Kim, Bong Jik

doi:10.3345/cep.2022.01011

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…There are three reasons for genetic hearing loss; (1) Non-syndromic and syndromic; (2) Autosomal dominant/recessive/X-linked; and (3) Mitochondrial inheritance patterns[ 32 ].…”

Section: Causesmentioning

confidence: 99%

“…The non-syndromic and autosomal recessive cases outnumber the cases of syndromic and autosomal dominant cases. This means that congenital hearing loss can occur with a negative family history of hearing loss or without systemic abnormalities, which might be an unexpected aspect of the family[ 32 ]. Several investigations studied adding genetic testing to the current universal newborn hearing screening.…”

Section: Causesmentioning

confidence: 99%

“…Despite the benefit of early detection of hearing loss in newborns and early infantile life having been recognized for 80 years, the real efforts on a country level to detect congenital hearing loss were started at the beginning of the last decade of the 20 th century[ 48 ]. Currently, the national universal newborn hearing screening program was practiced in all developed countries and some developing nations[ 32 , 45 , 49 ]. Unfortunately, Iraq is one of the developing countries that still have not practiced this vital program[ 50 ].…”

Section: Evaluation Of Hearing In Newbornsmentioning

confidence: 99%

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Various aspects of hearing loss in newborns: A narrative review

Al-Ani¹

2023

World J Clin Pediatr

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Hearing loss is considered the most common birth defect. The estimated prevalence of moderate and severe hearing loss in a normal newborn is 0.1%-0.3%, while the prevalence is 2%-4% in newborns admitted to the newborn intensive care unit. Neonatal hearing loss can be congenital (syndromic or non-syndromic) or acquired such as ototoxicity. In addition, the types of hearing loss can be conductive, sensorineural, or mixed. Hearing is vital for the acquisition of language and learning. Therefore, early detection and prompt treatment are of utmost importance in preventing the unwanted sequel of hearing loss. The hearing screening program is mandatory in many nations, especially for high-risk newborns. An automated auditory brainstem response test is used as a screening tool in newborns admitted to the newborn intensive care unit. Moreover, genetic testing and screening for cytomegalovirus in newborns are essential in identifying the cause of hearing loss, particularly, mild and delayed onset types of hearing loss. We aimed to update the knowledge on the various aspects of hearing loss in newborns with regard to the epidemiology, risk factors, causes, screening program, investigations, and different modalities of treatment.

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“…There are three reasons for genetic hearing loss; (1) Non-syndromic and syndromic; (2) Autosomal dominant/recessive/X-linked; and (3) Mitochondrial inheritance patterns[ 32 ].…”

Section: Causesmentioning

confidence: 99%

Section: Causesmentioning

confidence: 99%

Section: Evaluation Of Hearing In Newbornsmentioning

confidence: 99%

See 1 more Smart Citation

Various aspects of hearing loss in newborns: A narrative review

Al-Ani¹

2023

World J Clin Pediatr

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Research Progress on Embryonic Development, Genetic Regulation and Clinical Management of Congenital Middle Ear Malformations

Gao,

Li,

Yuan

et al. 2024

Flavour & Fragrance J

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Congenital middle ear malformations are a common hearing defect in newborns, primarily characterised by abnormal middle ear structures, particularly underdeveloped or malformed ossicular chains, resulting in conductive hearing loss. This article provides a comprehensive review of the embryonic development process of the middle ear and the genetic regulatory mechanisms, with a focus on the Tbx1 gene, which is closely related to middle ear development. Studies have shown that the Tbx1 gene plays a crucial role in the migration of neural crest cells and the formation of middle ear structures, and its mutation or abnormal expression can lead to developmental defects of the middle ear structure. These gene mutations affect downstream signalling pathways (such as FGF8, FGF10 and BMP4), which are essential in the formation of the ossicles, ear canal and middle ear cavity. Additionally, this article discusses the aetiology of congenital middle ear malformations, associated syndromes, clinical manifestations, classification, diagnosis and treatment strategies. Diagnostic methods for middle ear malformations include audiological examinations, imaging studies and genetic testing. Early diagnosis and intervention, such as surgical correction and the use of hearing aids, can help improve the hearing and quality of life of patients. This article aims to provide a reference and basis for further etiological research and precise treatment by elucidating the mechanisms and clinical features of middle ear malformations.

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