Hearing Loss in Progressive Systemic Sclerosis Patients: A Comparative Study

Kastanioudakis, Ioannis; Ziavra, Nafsika; Politi, Eudokia N; Exarchakos, Georgios; Drosos, Alexandros A.; Skevas, A.

doi:10.1067/mhn.2001.115092

Cited by 43 publications

(45 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the eight studies that investigated changes, all identified hearing loss in most individuals with SS, and the prevalence in this finding ranged from 20 to 77%. The type of hearing loss was bilateral sensorineural (6,(9)(10)(11)13,16,17) in most cases, corroborating the physiopathology of the systemic disease. However, mixed (11,15,17) and unilateral (13,17) hearing loss were also described in few cases.…”

Section: Resultssupporting

confidence: 56%

“…The most used study design for describing auditory and vestibular changes in individuals with SS was the crosssectional design, observed in five analyses (10)(11)(12)(13)(14) , followed by four case reports (6,9,15,16) , and one case-control study (17) . Because cross-sectional studies reported findings of a single moment, it was difficult to determine a temporal sequence between exposure to a specific factor and the subsequent development of the disease.…”

Section: Resultsmentioning

confidence: 99%

“…However, six studies aimed at assessing or reporting only auditory changes in these patients (6,9,11,13,15,16) and only two (12,14) investigated vestibular dysfunctions (Chart 1). It is possible to observe that symptoms of hearing loss, tinnitus, and vertigo were more frequently reported by individuals with SS.…”

Section: Resultsmentioning

confidence: 99%

“…The basic audiological evaluation (tone audiometry, vocal audiometry, and acoustic immittance) was the most used evaluation method to identify these changes in individuals with SS (6,10,11,13,15,17) . However, the brainstem auditory-evoked potentials (BAEP) and vestibular evaluation were also used for diagnostic investigation (6,10,13,17) .…”

Section: Resultsmentioning

confidence: 99%

“…However, studies show the occurrence of conductive hearing loss in other autoimmune diseases such as recidivant polychondritis, thus attributing this change to the expansion of the inflammatory process to the middle ear and auditory tube (19) . In one of the reviewed articles, the authors (11) identified the presence of eustachian tube pathology in 3 of the 30 evaluated patients. This change may explain the presence of the conductive component in the hearing loss of patients with ES.…”

Section: Chart 2 Symptoms and Auditory And Vestibular Findings In Symentioning

confidence: 99%

See 4 more Smart Citations

Auditory and vestibular dysfunctions in systemic sclerosis: literature review

Rabelo

Corona

2014

CoDAS

View full text Add to dashboard Cite

Purpose: To describe the prevalence of auditory and vestibular dysfunction in individuals with systemic sclerosis (SS) and the hypotheses to explain these changes. Research strategy: We performed a systematic review without meta-analysis from PubMed, LILACS, Web of Science , SciELO and SCOPUS databases, using a combination of keywords "systemic sclerosis AND balance OR vestibular" and "systemic sclerosis AND hearing OR auditory." Selection criteria: We included articles published in Portuguese, Spanish, or English until December 2011 and reviews, letters, and editorials were excluded. We found 254 articles, out of which 10 were selected. Data analysis: The study design was described, and the characteristics and frequency of the auditory and vestibular dysfunctions in these individuals were listed. Afterwards, we investigated the hypothesis built by the authors to explain the auditory and vestibular dysfunctions in SS. Results:Hearing loss was the most common finding, with prevalence ranging from 20 to 77%, being bilateral sensorineural the most frequent type. It is hypothesized that the hearing impairment in SS is due to vascular changes in the cochlea.The prevalence of vestibular disorders ranged from 11 to 63%, and the most frequent findings were changes in caloric testing, positional nystagmus, impaired oculocephalic response, changes in clinical tests of sensory interaction, and benign paroxysmal positional vertigo. Conclusion: High prevalence of auditory and vestibular dysfunctions in patients with SS was observed. Conducting further research can assist in early identification of these abnormalities, provide resources for professionals who work with these patients, and contribute to improving the quality of life of these individuals. RESUMOObjetivo: Descrever a prevalência das alterações auditivas e vestibulares em indivíduos com Esclerose Sistêmica (ES) e as hipóteses elencadas para explicar essas alterações. Estratégia de pesquisa: Revisão sistemática, sem meta-análise, a partir das bases de dados PubMed, LILACS, Isi Web of Science, SciELO e SCOPUS, utilizando a combinação das palavras-chave "systemic sclerosis AND balance OR vestibular" e "systemic sclerosis AND hearing OR auditory". Critérios de seleção: Foram incluídos artigos publicados em Português, Espanhol ou Inglês até dezembro de 2011e excluídos os artigos de revisão de literatura, cartas e editoriais. Foram localizados 254 artigos e selecionados dez. Análise dos dados: Foi realizada a descrição do delineamento dos estudos e elencadas as características e frequência das alterações auditivas e vestibulares. Após, investigaram-se as hipóteses formuladas pelos autores para explicar o comprometimento auditivo e vestibular na ES. Resultados: A perda auditiva foi o achado mais comum, com prevalência de 20 a 77%, sendo o tipo sensorioneural bilateral o mais frequente. Hipotetiza-se que o prejuízo auditivo na ES é decorrente de alterações vasculares na cóclea. A prevalência das alterações vestibulares variou de 11 a 63%, e os achados mais frequen...

show abstract

Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Chart 2 Symptoms and Auditory And Vestibular Findings In Symentioning

confidence: 99%

See 3 more Smart Citations

Auditory and vestibular dysfunctions in systemic sclerosis: literature review

Rabelo

Corona

2014

CoDAS

View full text Add to dashboard Cite

show abstract

Human otopathology in scleroderma

Castillo‐Bustamante,

Roychowdhury,

Gandhi

et al. 2023

Laryngoscope Investig Oto

View full text Add to dashboard Cite

ObjectiveScleroderma is a complex chronic progressive immune‐mediated disease that causes fibrosis of the skin and internal organs, and vasculopathy.Ear involvement has been poorly studied in patients with scleroderma. Vasculitic and autoimmune mechanisms are considered as possible etiologies on hearing impairment, however, this etiology still unclear.Herein, we reviewed three cases of scleroderma from a temporal bone repository.MethodsThe national temporal bone database was reviewed for cases with scleroderma. Clinical case review and correlative otopathologic analysis. Middle and inner ear otopathologic analysis was performed following hematoxylin and eosin staining under light microscopy. Findings were compared to three age‐matched controls.ResultsTwo patients (three cases) with a history of serologically confirmed scleroderma were identified. Both individuals reported tinnitus and demonstrated bilateral moderate to severe down‐sloping sensorineural hearing loss on audiometry. Histologically, the incudomallear joint space was diminished and ossicles appeared demineralized. A loss of hyaline cartilage, and obliteration of the incudomallear and incudostapedial joint synovial spaces was observed. Decreased caliber and intimal hyperplasia of arteries adjacent to ossicles was also identified. Mild diffuse atrophy of stria vascularis in the middle and apical turns of cochlea were found. Hair cell populations were normal. Total spiral ganglion neurons were lower in cases of scleroderma (range 29%–51%) compared to age‐matched controls.ConclusionFibrosis, inflammation, and vascular changes were observed in the middle and inner ear in patients with scleroderma. Findings have implications for understanding hearing and vestibular dysfunction in this patient population.Level of evidenceRetrospective study.

show abstract

Overlooked Manifestations

Shah¹

2011

Scleroderma

View full text Add to dashboard Cite

Hearing Loss in Progressive Systemic Sclerosis Patients: A Comparative Study

Cited by 43 publications

References 10 publications

Auditory and vestibular dysfunctions in systemic sclerosis: literature review

Auditory and vestibular dysfunctions in systemic sclerosis: literature review

Human otopathology in scleroderma

Overlooked Manifestations

Contact Info

Product

Resources

About