Unilateral sensorineural hearing loss (SNHL) affects people at any age, can present as an acute and/or progressive process, and can range from mild to profound. Although the great majority of cases have an unknown cause, the known causes of unilateral SNHL need to be excluded including neoplasms, stroke, demyelinating and autoimmune diseases, infection, perilymphatic fistula, and Ménière's disease. The majority of individuals with idiopathic sudden SNHL will recover complete or partial hearing. However, there is a small subset of patients who remain with unilateral hearing impairment, which can result in communication difficulties. The goal of this article is to present the etiology and medical management of unilateral SNHL in the adult population.KEYWORDS: Baha (bone-anchored hearing aid), CROS (contralateral routing of the signal), single-sided deafness, unilateral sensorineural hearing loss Learning Outcomes: As a result of this activity, the participant will be able to (1) list possible etiologies of unilateral sensorineural hearing loss (SNHL) in adults, and (2) list management options for adults with unilateral SNHL.