Hearing Outcomes of Infants Born to Mothers With Active COVID-19 Infection

Kosmidou, Panagiota; Karamatzanis, Ioannis; Tzifas, Sotiris; Vervenioti, Aggeliki; Gkentzi, Despoina; Dimitriou, Gabriel

doi:10.7759/cureus.25571

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Similar to our ndings, most studies published during the covid-19 pandemic do not support strong evidence of auditory system insult due to intrauterine infection by the SARS-CoV-2 virus mirrored on normal newborn hearing screening tests [14,[37][38][39][40][41]. However, other studies are showing a possible negative impact on hearing of newborns of mothers infected by covid-19 during pregnancy [15,16].…”

Section: Discussionsupporting

confidence: 63%

Hearing Screening Test in neonates born to COVID-19-positive mothers

Goulioumis

Angelopoulou

Mourtzouchos

et al. 2022

Preprint

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Purpose SARS-CoV-2, the responsible virus for the covid-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from covid-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss. Methods This is a retrospective study in a regional pediatric hospital. The medical records of newborns (n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study. Results For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested. Conclusions Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies.

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Section: Discussionsupporting

confidence: 63%

Hearing Screening Test in neonates born to COVID-19-positive mothers

Goulioumis

Angelopoulou

Mourtzouchos

et al. 2022

Preprint

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“…They observed no statistically significant difference between cases and controls. Kosmidou et al [ 21 ] reported that 21.87% of neonates failed the first screening while all these neonates cleared the second screening. A study by Tanyeri Toker et al reported no significant association between COVID-19 infection during different trimesters and congenital hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Gestational Mild COVID-19 Infection Associated Neonatal Hearing Loss: A Case-Control Study from North India

Rajanna

Raina

Bhatia

et al. 2023

Indian J Otolaryngol Head Neck Surg

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COVID-19 infection during pregnancy is potentially dangerous to neonatal hearing, as it is the period of organogenesis, and associated hyperthermia may cause vascular damage, disruption of cell migration, and death of the dividing neuroblasts. To investigate the possible association between neonatal hearing loss and gestational mild COVID-19 infection. A prospective case-control study was conducted at a tertiary healthcare centre in North India from March 2020 to Oct 2022. Cases included the neonates born to COVID-19-positive mothers were subjected to hearing screening at 1, 3 and 6 months using otoacoustic emission (OAE) and automated auditory brainstem response (AABR). Similar protocol was applied to controls, i.e., neonates borne to mothers with no gestational history of COVID infection. Results were analyzed statistically. Our study reported that the statistical difference between groups A (n = 942) and B (n = 942) for gestational COVID-19 infection and neonatal hearing loss was insignificant at 1 month ( p -value 0.272 for OAE and p -value 0.634 for AABR) and also insignificant at 3 and 6 months ( p -value 0.679 for AABR, for both). The association between gestational mild COVID-19 infection during gestation and neonatal hearing loss is statistically insignificant at initial screening as well as sequential screenings.

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Risk of Hearing Loss in Neonates and Toddlers with in Utero Exposure to SARS‐CoV‐2

Ahmed,

Yu,

Chaves

et al. 2024

The Laryngoscope

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ObjectiveGiven the prevalence of neonatal hearing loss (HL) associated with intrauterine viral exposures, the goal of this study is to provide information on neonatal HL in the context of the COVID‐19 pandemic.MethodsData were drawn from the COVID‐19 Mother Baby Outcomes (COMBO) Initiative. 1007 participants completed the newborn hearing screen as part of routine clinical care (COMBO‐EHR cohort) and 555 completed the National Survey of Children's Health (NSCH) at 2 and/or 3 years of age for research purposes (COMBO‐RSCH cohort). Maternal SARS‐CoV‐2 infection status during pregnancy was determined through electronic health records and maternal‐reported questionnaires.ResultsIn adjusted multivariate logistic regression models covarying for newborn age at assessment, mode of delivery, and gestational age at delivery, there was no significant association between intrauterine SARS‐CoV‐2 exposure and newborn hearing screening failure (OR = 1.05, 95% CI = 0.39–2.42, p = 0.91) in the COMBO‐EHR cohort. In the COMBO‐RSCH cohort, there were similar non‐significant associations between intrauterine exposure to SARS‐CoV‐2 and maternal‐reported concern for HL on the NSCH (OR = 1.19 [95% CI = 0.30–4.24], p = 0.79).ConclusionThere is no association between intrauterine exposure to SARS‐CoV‐2 and failed hearing screen in neonates. Similarly, based on the NSCH, there is no association between intrauterine exposure to SARS‐CoV‐2 and maternal‐reported concern for hearing in toddlers. These results offer reassurance given the widespread nature of this pandemic with tens of millions of fetuses having a history of intrauterine exposure.Level of EvidenceLevel 4 Laryngoscope, 2024

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Hearing Outcomes of Infants Born to Mothers With Active COVID-19 Infection

Cited by 5 publications

References 25 publications

Hearing Screening Test in neonates born to COVID-19-positive mothers

Hearing Screening Test in neonates born to COVID-19-positive mothers

Gestational Mild COVID-19 Infection Associated Neonatal Hearing Loss: A Case-Control Study from North India

Risk of Hearing Loss in Neonates and Toddlers with in Utero Exposure to SARS‐CoV‐2

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