Hearing the Vagus Nerve’s Rhythm in Patients with Paroxysmal Atrial Fibrillation

Нечепуренко, А. А.; Покровский, В. М.; Тарасов, Д Г; Китиашвили, И. З.; Абушкевич, В. Г.

doi:10.15360/1813-9779-2020-3-46-53

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…A relationship was established between the area of the focus of initial excitation and the duration of the disease. The shorter the duration of the disease, the larger was the focus of the initial excitation (Nechepurenko and Romantsov 2020).…”

Section: Introductionmentioning

confidence: 99%

“…In experiments on animals, when visualizing the focus of initial excitation in a high-frequency electromagnetic field, it was shown that the area of the focus of initial excitation was determined by combining pacemaker cell (PC) pools of the sinoatrial node (SAN) (Pokrovsky et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, this can be explained from the perspective of the concept by V.M. Pokrovsky about the hierarchical system of rhythmogenesis, according to which, the heart rhythm in a whole body under natural conditions originates in the brain in the form of volleys of nerve impulses arriving along the vagus nerves (VN) to the SAN, and, when interacting with the autogenous structures of the SAN, the heart rhythm is formed (Pokrovsky 2007).…”

Section: Introductionmentioning

confidence: 99%

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The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

Nechepurenko,

Galenko-Yaroshevsky,

Pokrovskiy

et al. 2023

RRP

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Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmias. Studying the pathogenesis of this pathological process will make it possible to look for new methods of treating AF and to predict its occurrence in a more targeted way. The aim of the study was to identify the components of the takeover process of central rhythmogenesis by the SA node in the conditions of atrial fibrillation when stimulating the vagus nerve and using substance SS-68. Materials and Methods: The experiments were conducted on 30 frogs and 90 cats. In frogs, the activity of the regions of the medulla oblongata synchronous with the heart rhythm was determined in a high-frequency electromagnetic field. In cats, proximal and distal foci of luminescence in the vagus nerve (VN) and pools of pacemaker cells (PCs) in the sinoatrial node were visualized under topical and general anesthesia, using a KELSY scanner with a microscope video capture unit while stimulating VN and using SS-68. Results and Discussion: The stimulation of VN with volleys of electrical impulses and the introduction of SS-68 increase the foci of luminescence in the nerve and unite the PC pools. This way, under general anesthesia in comparison with topical anesthesia, the area of the proximal focus of VN luminescence decreased by 83.8%, and the distal focus – by 44.9%. Against the background of general anesthesia, the area of the proximal focus of luminescence when stimulating VN with volleys of electrical impulses was by 76.0% larger than before stimulation, and the distal focus – by 72.5%. After the administration of SS-68, there was an increase in the foci of luminescence: under general anesthesia, when compared with topical anesthesia, the area of the proximal foci of luminescence decreased by 86.8%, and the distal one – by 67.1%. Under general anesthesia, the area of the proximal focus of luminescence under conditions of stimulating VN with volleys of electrical impulses was by 82.2% larger than before stimulation and the distal one – by 78.2%. When signals from the brain arrive simultaneously through VN at the PC pools, they are absorbed by the PC pools; the focus of early depolarization becomes wide, which prevents the development of AF. The increased synchronizing influence of VN may be one of the methods for treating autonomic AF, and if its influence decreases, it can be a prognostic factor for the occurrence of recurrent AF. Conclusion: The tonic effect of VN on the heart rhythm through electrical stimulation of the former and the use of SS-68 is manifested in a decreased heart rate: the difference between the initial heart rhythm and the minimal synchronization range boundary. A decrease in the heart rate under the influence of VN prevents paroxysms of AF, but does not completely eliminate the influence of ectopic foci on it.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

Nechepurenko,

Galenko-Yaroshevsky,

Pokrovskiy

et al. 2023

RRP

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Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

Galenko-Yaroshevsky¹,

Нечепуренко²,

Pokrovskaya³

et al. 2021

RRP

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Introduction: Cardiac pacing is indicated for sick sinus syndrome. It is performed with a pacemaker via electrodes implanted in the heart. This technique has several disadvantages. The search for alternative methods of cardiac pacing is underway. One of them is control of heart rhythm through stimulation of the tragus. Objective: To perform the reflex stimulation of the sinoatrial node and to study the influence of the SS-68 substance on it. Materials and methods: Two electrodes were fixed in the reflexogenic zone of rabbits’ auricles, volleys of electrical impulses from an electrical stimulator were applied to the electrodes, and the synchronization range of volley frequency and cardiac contractions was recorded. This range was re-recorded again after injecting the SS-68 substance (2-phenyl-1-(3-pyrrolidine-1-cyclopropyl)-1H-indole hydrochloride) intravenously at a dose of 50 µg/kg. In other experiments on frogs in a high-frequency electromagnetic field, the process of excitation of the area of the medulla oblongata associated with the heart rhythm was visualized. After the application of SS-68 (50 μM) to the surface of this zone, the process of its excitation was recorded. Results and discussion: Stimulation of the auricular reflexogenic zone of rabbits produced a synchronization of volley frequency and heart rate in the range from 173.5 ± 2.0 to 214.0 ± 1.8 per minute. SS-68 extended this range from 168.2 ± 1.9 to 219.4 ± 1.5 per minute. In the frog’s medulla oblongata, an area synchronous to the heart rhythm glowed in the high-frequency electromagnetic field. SS-68 increased the area of glow by 131.0%. Conclusion: The substance SS-68 increases the frequency range of heart rhythm control by activating reflex stimulation of the sinoatrial node. The main point of application of SS-68 is the medulla oblongata. Glow in the high-frequency electromagnetic field reflects the process of neuron excitation. The increase in the glow zone under the influence of SS-68 indicates synchronously excited neurons, which leads to the assimilation of the central heart rhythm generation by the sinoatrial node.

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Hearing the Vagus Nerve’s Rhythm in Patients with Paroxysmal Atrial Fibrillation

Cited by 2 publications

References 17 publications

The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

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