Heart-Disease and Influenza

Bourne, Geoffrey; Wedgwood, J

doi:10.1016/s0140-6736(59)90899-2

Cited by 18 publications

(7 citation statements)

References 2 publications

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“…Patients leaving these hospitals with respiratory infections may pose a health risk to others in their communities [18,19]. The fact that 25% of hospital-acquired respiratory disease occurred in patients hospitalized for cardiovascular disease, stroke, and myocardial infarction is concerning, because acute respiratory illness in this group-particularly influenza-is associated with increased risk of complications and poor health outcomes [20][21][22]. The data were not analyzed on a monthly basis by hospital staff; however, rates could easily be calculated and clusters identified in hospitals in real time.…”

Section: Discussionmentioning

confidence: 99%

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

et al. 2010

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Patients on these study wards frequently experienced hospital-acquired respiratory infections, including 1 in every 20 patients hospitalized for >72 h on 1 ward. The surveillance method was useful in calculating rates of hospital-acquired respiratory illness and could be used to enhance capacity to quickly detect outbreaks of respiratory disease in health care facilities where systems for outbreak detection are currently limited and to test interventions to reduce transmission of respiratory pathogens in resource-poor settings.

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Section: Discussionmentioning

confidence: 99%

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

et al. 2010

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“…Although several clinical reports on the occurrence of myocarditis following influenza virus infection have appeared (2,5,16), experimental studies on influenza virus-induced myocarditis still remain incomplete in regard to its reproducibility and pathogenic mechanisms (11, 18). The present study shows that in limited experimental conditions, myocarditis is induced in mice at frequency as high as 82% by inhalation of influenza A z virus.…”

Section: Discussionmentioning

confidence: 99%

“…In a preliminary experiment (data not shown), we failed to induce myocarditis in DDI mice with the PR-8 strain of influenza A virus (HoNl)' which indicates that there may be a difference in the potential for inducing myocarditis among virus strains. Such a difference among strains in myotropism might explain the relative paucity of the development of myocarditis in human influenza pandemics (2). Butchko and Armstrong (3) demonstrated that, among five influenza subtype strains, only the influenza A z virus (HzN z) strains had the ability to induce lymphocyte proliferation in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Many viruses, for example coxsackie (9,20), echo (14), mumps (1), herpes (4,7), and influenza (11,18) viruses, are known to be causative agents of myocarditis, and the pathogenic mechanism of some of them (4,21) has been analyzed. Myocarditis that occurs after influenza virus infection has been studied experimentally (11,18) and clinically (2,5,16), but its pathogenesis remains to be clarified.…”

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confidence: 99%

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Experimental Myocarditis Induced in Mice by Infection with Influenza A₂ Virus

Sakamoto

Suzuki

Arai

et al. 1981

Microbiology and Immunology

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A mouse model was established for the study of acute myocarditis that occurs during influenza infection. Challenge with more than 10 LD50 of mouseadapted influenza A 2 virus (H2N2) induced myocarditis macroscopically discernible as white, irregularly shaped lesions which were shown by histological examination to consist of necrotic myofibers surrounded by infiltrating mononuclear inflammatory cells. After challenge with 10 LD 50 of the virus, macroscopic myocarditis was found to advance in a progressive manner up to the 7th day, while the virus titer in the heart reached its peak on the 2nd day and began to decrease on the 5th day of infection. However, development of myocarditis was significantly suppressed in mice which were irradiated with 400 R of X-rays before infection. In addition, myocarditis did not develop in congenitally athymic nude mice.These data indicate that myocarditis was not brought about by viral action directly, but that it was mediated by some function of the host against viral invasion, which was abolished by X-irradiation. The data also suggest that T cells played a key role in the development of myocarditis.

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“…But many workers have shown experimentally that (1) the embryo can be damaged by normal metabolites (Coffey and Jessop, 1959) and (2) can be no lack of metabolites arising from the damaged mucosa of the respiratory tract or even from the virus itself. Thus, metabolites which produced systemic reaction were reported by Bourne and Wedgwood (1959) and Skanse and Miorner (1959) in connection with the epidemic of Asian influenza.…”

mentioning

confidence: 81%

Epidemiological studies concerning choice of population for immunoprophylaxis of influenza

Niculescu

Zilişteanu

Creţescu

et al. 1976

Postgraduate Medical Journal

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Epidemiological studies in naturally infected persons have shown that there is a significant relation between antibody levels to the current circulating virus and morbidity. Serological findings and morbidity data suggest: (1) that the serological survey is a more sensitive indicator for influenza outbreaks than is the clinical diagnosis and (2) that the 5-14 age group is first affected when an epidemic of influenza starts off. Consequently, school children may be the major source of influenza into family units and, therefore, among older segments of the population. Exploring the relationships between influenza morbidity and natality, as well as influenza morbidity and mortality under 1 year of age, values of <0·001 (Student's t-test) were obtained. The linear regression analysis showed that both relationships were represented as straight lines. From the results it seems logical to utilize the available vaccine for the protection of infants, school children and pregnant women. The vaccine-induced protection can offer significant, although not total, protection of the whole population and prevent obstetrical accidents.

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Heart-Disease and Influenza

Cited by 18 publications

References 2 publications

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

Experimental Myocarditis Induced in Mice by Infection with Influenza A₂ Virus

Epidemiological studies concerning choice of population for immunoprophylaxis of influenza

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Heart-Disease and Influenza

Cited by 18 publications

References 2 publications

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

Rates of Hospital‐Acquired Respiratory Illness in Bangladeshi Tertiary Care Hospitals: Results from a Low‐Cost Pilot Surveillance Strategy

Experimental Myocarditis Induced in Mice by Infection with Influenza A2 Virus

Epidemiological studies concerning choice of population for immunoprophylaxis of influenza

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Experimental Myocarditis Induced in Mice by Infection with Influenza A₂ Virus