“…In this special issue we have invited a few papers that address such issues and explain why, despite the emergence of novel therapeutic approaches that promise life prolongation and hospital length reduction, this patient population will still be needing rehospitalization and will often have a poor prognosis. This special issue is the extension of an effort that was initiated in 2011 with the first heart failure-focused issue, [ 2 ] coupled with a second focused issue a year later [ 3 ].…”