Heart Failure with Hyperthyroidism Demonstrating Discrepancy between the Clinical Course and B-type Natriuretic Peptide Levels

Kishida, Chiaki; Naito, Ryo; Kasuya, Hiroki; Kaneko, Takeshi; Yabe, Kosuke; Kakihara, Midori; Shimai, Ryosuke; Isogai, Hiroyuki; Ozaki, Dai; Yasuda, Yuki; Odagiri, Fuminori; Miyazaki, Tatsuya; Yokoyama, Ken; Tokano, Takashi; Koyano, Hajime; Nakazato, Yuji

doi:10.2169/internalmedicine.0118-17

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…Prior studies have also shown a correlation between BNP levels and thyroid levels in patients without heart failure or cardiac disease [31,32]. BNP level was found to be 4-fold higher in patients with hyperthyroidism than in patients in a euthyroid state.…”

Section: Hyperthyroidism and Brain Natriuretic Peptide (Bnp)mentioning

confidence: 67%

“…It is postulated that THs may stimulate the secretion of BNP, in addition to the main physiologic process: stimulation via stretching of the atrial myocardial tissue. Prior studies have shown that free T3 hormone directly stimulates the secretion of BNP from myocardial cells by increasing gene expression [31,33,34].…”

Section: Hyperthyroidism and Brain Natriuretic Peptide (Bnp)mentioning

confidence: 99%

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Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure

et al. 2020

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The association between thyroid hormones and cardiovascular conditions has been well studied, specifically, the effects of hypothyroidism on cardiomyopathy, and hyperthyroidism with arrhythmias. Nonetheless, an explicit correlation between hyperthyroidism and cardiomyopathy has yet to be established. Medical databases MEDLINE and PubMed were accessed and queried as primary sources for data acquisition. Search criteria consisted of "hyperthyroidism", "heart failure", and "thyroid and cardiovascular system", which allowed the retrieval of relevant and recent works. From these sources, a consensus was developed and employed to yield an updated review of the etiology of heart failure in the setting of hyperthyroidism. It is rare for patients with hyperthyroidism to remain in a chronic hyperthyroid state, making it difficult to analyze subsequent long-term effects on the cardiovascular system. Related to heart failure, some studies have demonstrated no change in ejection fraction, while others have shown an acute change along with diastolic dysfunction, with or without an underlying rhythm abnormality. Further investigation is warranted to elucidate the mechanism driving such cardiac dysfunction, and whether it is due to vascular changes, tachyarrhythmias, or myocyte remodeling and fibrosis. The intent of this review article is to improve our understanding of how a hyperthyroid state affects cardiovascular function. An enhanced understanding of the effects on cardiovascular physiology will afford physicians the ability to provide more comprehensive care in consideration of both endocrine and cardiovascular pathologies.

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Section: Hyperthyroidism and Brain Natriuretic Peptide (Bnp)mentioning

confidence: 67%

Section: Hyperthyroidism and Brain Natriuretic Peptide (Bnp)mentioning

confidence: 99%

Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure

et al. 2020

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“…Within the scenario of acute exacerbation, the measurement of serum natriuretic peptides is useful, particularly in scenarios of patients with multiple comorbidities whose main symptom is dyspnea. Elevated BNP or NT-proBNP values are consistent with the cardiac etiology of dyspnea and are also usefulness as prognostic markers [ 69 , 70 ]. The use of other imaging aids, such as magnetic resonance imaging, for the diagnosis of heart failure has also been reported; however, these techniques are not generally available and have high costs, and their use is not standardized [ 71 ].…”

Section: Hyperthyroidism and Heart Failurementioning

confidence: 99%

Cardiac manifestations in hyperthyroidism

Navajas¹,

Cruz²,

Ordoñez³

et al. 2022

Rev. Cardiovasc. Med.

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Thyroid hormones have a fundamental impact on cardiac function that is mediated by genomic and nongenomic effects, alterations that condition physiological repercussions that lead to changes in frequency, contractility, rhythm and cardiac output as well as an increase in the incidence and prevalence of different cardiovascular diseases. This document presents an updated review of the implications that hyperthyroidism has in different cardiac conditions, including its importance in the evaluation of perioperative cardiovascular risk.

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“…It was noted that FT3 has a direct stimulus for the BNP secretion from myocardial cells by increasing the gene expression. Thus, THs in a direct action increase myocardial BNP gene expression 57,58 .…”

Section: Introductionmentioning

confidence: 99%

The effect of subclinical thyroid dysfunction on B- type natriuretic peptide level

Al-Sultan

Hayawi

et al. 2022

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Thyroid hormones (THs) have a significant effect on the cardiovascular system. THs increase myocardium stretch, leading to the release of B-type Natriuretic Peptide (BNP), which is considered a diagnostic biomarker of heart failure (HF). Thyroid dysfunctions (subclinical hypothyroidism; SCH and subclinical hyperthyroidism; SCHyper) stimulate several changes in the heart by causing either diastolic or systolic left ventricular dysfunctions leading to HF. This study aims to measure the changes of B- type NP levels in cases of subclinical hypo and hyperthyroidism. The present study aims to measure the changes in B-type Natriuretic Peptide (BNP) levels in subclinical hypo and hyperthyroidism (SCH and SCHyper). A theoretical study was also conducted using a docking program to find the effectiveness of some drugs in inhibiting or promoting B-type Natriuretic Peptide (BNP). A case study was conducted in a private clinic, Mosul- Iraq, from (April 1st – Sep 1) 2021, with 25 healthy participants with normal functioning thyroids as a control group (EU). A newly diagnosed 25 SCH and 17 SCHyper patients participated in this study, considering that none of them have thyroid dysfunctions taking medicine, hypertension, heart diseases, renal failure, and pregnant women. They all were checked for Thyroid Function Tests (TFTs), Free Triiodothyronine (FT3), Free Thyroxin (FT4) and Thyroid Stimulating Hormone (TSH). The plasma level of BNP was measured in all participants of the three groups. The results showed that the plasma level of BNP was higher in SCHyper patients (10.97 pg/ml) as compared to that of SCH patients (8.09 pg/ml) and EU subjects (8.27 pg/ml). Hereby, we could state that subclinical hyperthyroidism, SCHyper, triggers BNP release. Therefore, it should be kept in mind that any high BNP levels due to SCHyper should be considered a reliable diagnostic biomarker of heart failure (HF). Keywords. Thyroid hormone(TH), Subclinical hypothyroidism(SCH), Subclinical hyperthyroidism(SCHyper), Chronic heart disease(CHD), Heart failure(HF), B-type natriuretic peptide(BNP), Docking Study.

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Heart Failure with Hyperthyroidism Demonstrating Discrepancy between the Clinical Course and B-type Natriuretic Peptide Levels

Cited by 7 publications

References 13 publications

Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure

Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure

Cardiac manifestations in hyperthyroidism

The effect of subclinical thyroid dysfunction on B- type natriuretic peptide level

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