Heart Failure With Preserved Ejection Fraction in Outpatients With Unexplained Dyspnea

Pěnička, Martin; Bartúnek, Jozef; Trakalova, Helena; Hrabakova, Hana; Maruskova, Michaela; Karásek, Jiří; Kočka, Viktor

doi:10.1016/j.jacc.2009.11.076

Cited by 159 publications

(156 citation statements)

References 27 publications

(28 reference statements)

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“…Shortness of breath is unquestionably a cardinal symptom of HFpEF 207. However, when it fails to resolve with loop diuretic therapy, shortness of breath may be an angina equivalent.…”

Section: Cad Phenotypementioning

confidence: 99%

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

Samson

Jaiswal

Ennezat

et al. 2016

JAHA

110

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“…Shortness of breath is unquestionably a cardinal symptom of HFpEF 207. However, when it fails to resolve with loop diuretic therapy, shortness of breath may be an angina equivalent.…”

Section: Cad Phenotypementioning

confidence: 99%

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

Samson

Jaiswal

Ennezat

et al. 2016

JAHA

110

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“…1) mit komplexen Algorithmen unter Einschluss von echokardiographischen strukturellen Parametern von LA und LV sowie Biomarkern. Diese multiplen nichtinvasiven Kriterien haben sich in der praktischen Routine für die Diagnostik von HFpEF als teilweise nicht sensitiv oder unschlüssig erwiesen [13,19,24], fraglichistaucheine Eignung zur Früherkennung der DD für die effektive Prävention einer Herzinsuffizienz. Die Limitationen von E/E' und strukturellen LV bzw.…”

Section: Definition Und Echokardiographische Bestimmungskriterienunclassified

“…

[13,19,24], fraglichistaucheine Eignung zur Früherkennung der DD für die effektive Prävention einer Herzinsuffizienz. Die Limitationen von E/E' und strukturellen LV bzw.

…”

unclassified

Diastolische Dysfunktion

Bibra

Paulus

2016

Kardiologe

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[13,19,24], fraglichistaucheine Eignung zur Früherkennung der DD für die effektive Prävention einer Herzinsuffizienz. Die Limitationen von E/E' und strukturellen LV bzw. LA Parametern als diagnostische Kriterien der DD bedingen einen wachsenden Bedarf an sensitiver Quantifizierung der DD auf einer Grundlage, die der Dynamik der Verän-derungen der LV diastolischen Funktion Rechnung trägt [8,35].Die traditionell in der Praxis übli-chen echokardiographischen Methoden der diastolischen Funktionsbestimmung über den Mitralklappeneinstrom (E/A) sind inzwischen durch quantifizierende Funktionsparameter mittels Gewebedoppler (frühdiastolische Myokardgeschwindigkeit E' und spätdiastolische A') ergänzt bzw. ersetzt worden (. Abb. 2), zumal der LV Füllungsdruck hiermit als E/E' abgeschätzt werden kann [22]. Abkürzungen BMIBody-Mass-Index

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“…The noninvasive diagnostics of left ventricular (LV) diastolic dysfunction relies on the analysis of natriuretic peptides and on parameters obtained from 2-dimensional and Doppler echocardiography 2 . Although a diagnostic approach utilizing parameter combinations appears superior to the application of only individual markers of diastolic dysfunction [3][4][5] , the noninvasive HFNEF diagnostics still has limitations 6 . At present, the major risk factors for HFNEF are aging, hypertension, and diabetes mellitus; i.e.…”

Section: Introductionmentioning

confidence: 99%

Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?

Meluzı́n¹,

Tomandl²,

Podroužková³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF). Methods and Results. 91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 µg/L vs. 3.5 µg/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis. Conclusion Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.

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Heart Failure With Preserved Ejection Fraction in Outpatients With Unexplained Dyspnea

Abstract: A significant proportion of stable outpatients with unexplained chronic dyspnea may have HFPEF. In the patients whom we studied, increased LV stiffness, dyssynchrony, and dynamic mitral regurgitation were the major mechanisms underlying development of HFPEF.

Cited by 159 publications

References 27 publications

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction

Diastolische Dysfunktion

Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?

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