Heart Muscle Tissue Engineering

Coffee, Michelle; Biswanath, Santoshi; Bolesani, Emiliano; Zweigerdt, Robert

doi:10.1007/978-3-030-33923-4_6

Cited by 3 publications

(2 citation statements)

References 134 publications

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“…Tissue engineering strategies, including the regeneration, repair and healing of bone [1], myocardium [2], skin [3] and other soft tissues, use temporary synthetic scaffolds to aid the natural healing of tissue defects. Electrospinning is a well-known method for fabricating micro-and nano-fiber mats from polymer solutions or melts [4].…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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Vascularization is necessary in tissue engineering to keep adequate blood supply in order to maintain the survival and growth of new tissue. The synergy of biologically active ions with multi-target activity may lead to superior angiogenesis promotion in comparison to single-target approaches but it has been rarely investigated. In this study, polycaprolactone (PCL) fiber mats embedded with B and Co co-doped bioactive glass nanoparticles (BCo.BGNs) were fabricated as a tissue regeneration scaffold designed for promoting angiogenesis. BCo.NBGs were successfully prepared with well-defined spherical shape using a sol-gel method. The PCL fiber mats embedding co-doped bioactive glass nanoparticles were fabricated by electrospinning using benign solvents. The Young’s moduli of the nanoparticle containing PCL fiber mats were similar to those of the neat fiber mats and suitable for scaffolds utilized in soft tissue repair approaches. The mats also showed non-cytotoxicity to ST-2 cells. PCL fiber mats containing BCo.BGNs with a relatively high content of B and Co promoted the secretion of vascular endothelial growth factor to a greater extent than PCL fiber mats with a relatively low B and Co contents, which demonstrates the potential of dual ion release (B and Co) from bioactive glasses to enhance angiogenesis in soft tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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“…Advancements in the field of nanotechnology have further improved the prospects of cardiac tissue engineering by generating superior scaffolds, injectable hydrogels, and conductive cell-laden cardiac patches. For the latter, biomaterials also play an important role in providing the correct signalling cues and extracellular matrix (ECM) to support differentiation and maturation of stem cells into mature cardiomyocytes [ 140 , 141 ]. A successful scaffold mimics the structural and chemical composition of native ECM of the myocardium.…”

Section: Application Of Cnms In Cardiovascular Tissue Engineeringmentioning

confidence: 99%

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Alagarsamy

Mathan

Yan

et al. 2021

Bioactive Materials

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.

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A Review of the Development and Challenges of Cell Mechanical Models

Zhang

et al. 2023

IEEE Trans.on Nanobioscience

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Heart Muscle Tissue Engineering

Cited by 3 publications

References 134 publications

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

A Review of the Development and Challenges of Cell Mechanical Models

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