Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening

Criscione, Joseph; Rezaei, Zahra; Cantu, Carol M. Hernandez; Murphy, Sheldon D.; Shin, Su Ryon; Kim, Deok Ho

doi:10.1016/j.bios.2022.114840

Cited by 33 publications

(23 citation statements)

References 159 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These microdevices allow to set up a dynamic tissue culture to control specific microphysiological conditions, also combining electrical, mechanical, and topographical stimuli and eventually integrating biosensors to obtain a real-time and continuous monitoring of dynamic tissue behaviors ( Criscione et al, 2023 ). Ideally, different organs-on-a-chip in series will be able to recapitulate the systemic effects of drugs across multiple organs ( Skardal et al, 2020 ; Picollet-D’hahan et al, 2021 ).…”

Section: Current Limitations and Promising Avenues With The Use Of Hi...mentioning

confidence: 99%

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Bissoli

D’Adamo²,

Pignatti³

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Section: Current Limitations and Promising Avenues With The Use Of Hi...mentioning

confidence: 99%

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Bissoli

D’Adamo²,

Pignatti³

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

“…As a proof of concept, cardiac troponin-I (cTnI) was quantified as a cardiotoxic biomarker. 34 From the results of comparative studies between bare MBs and MB-ZnO NRs, it is clear that fluorescence enhancement is critical for developing bead-based quantitative biosensors integrated with a microfluidic chip. Our fluorescence-enhanced MB-ZnO NRs can potentially replace endpoint measurements in many possible applications for biomarker measurements in organ-on-a-chips, 35 point-of-care testing systems, 36 and on-site clinical acute biomarker monitoring.…”

Section: Introductionmentioning

confidence: 99%

“…Our biosensor platform based on the MB-ZnO NRs with fluorescence enhancement was demonstrated for an affinity assay based on the binding of target biomolecules with aptamer duplex probes intercalated with an organic dye. As a proof of concept, cardiac troponin-I (cTnI) was quantified as a cardiotoxic biomarker . From the results of comparative studies between bare MBs and MB-ZnO NRs, it is clear that fluorescence enhancement is critical for developing bead-based quantitative biosensors integrated with a microfluidic chip.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence-Enhanced Microfluidic Biosensor Platform Based on Magnetic Beads with Highly Stable ZnO Nanorods for Biomarker Detection

Meeseepong

Ghosh

Shrivastava

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Existing affinity-based fluorescence biosensing systems for monitoring of biomarkers often utilize a fixed solid substrate immobilized with capture probes limiting their use in continuous or intermittent biomarker detection. Furthermore, there have been challenges of integrating fluorescence biosensors with a microfluidic chip and low-cost fluorescence detector. Herein, we demonstrated a highly efficient and movable fluorescence-enhanced affinity-based fluorescence biosensing platform that can overcome the current limitations by combining fluorescence enhancement and digital imaging. Fluorescence-enhanced movable magnetic beads (MBs) decorated with zinc oxide nanorods (MB-ZnO NRs) were used for digital fluorescence-imaging-based aptasensing of biomolecules with improved signal-to-noise ratio. High stability and homogeneous dispersion of photostable MB-ZnO NRs were obtained by grafting bilayered silanes onto the ZnO NRs. The ZnO NRs formed on MB significantly improved the fluorescence signal up to 2.35 times compared to the MB without ZnO NRs. Moreover, the integration of a microfluidic device for flow-based biosensing enabled continuous measurements of biomarkers in an electrolytic environment. The results showed that highly stable fluorescence-enhanced MB-ZnO NRs integrated with a microfluidic platform have significant potential for diagnostics, biological assays, and continuous or intermittent biomonitoring.

show abstract

“…It has the advantages of low sample consumption, fast analysis speed, and high sensitivity. Microfluidics can achieve accurate and highdensity medical testing [9][10], drug screening [11], cell culture [12][13], and other work. This article mainly proposes a control and driving method for the generation of piezoelectric micro droplets, which is based on the control of the driving signal of the piezoelectric transducer to achieve the generation of micro fluid droplets.…”

Section: Introductionmentioning

confidence: 99%

High Precision Piezoelectric Micro Droplet Control and Generation System

Zhao,

Li,

Dong

et al. 2023

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

To analyze and design an intelligent system that can achieve the generation and control of micro droplets. This article is based on the ANSYS finite element analysis and calculation software to design a fluid piezoelectric actuator with a circular oscillator, establish an overall structural model, and provide the design principle and driving structure of the piezoelectric actuator. And different control methods and driving performance were explored. We studied the simulation method of calculating the pressure at the nozzle through the variation of signal excitation amplitude and the control basis of micro droplets. Through the excitation signal, the movement of the fluid can be controlled, and the driving control effect of the fluid has been verified through simulation calculations.

show abstract

Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening

Cited by 33 publications

References 159 publications

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Fluorescence-Enhanced Microfluidic Biosensor Platform Based on Magnetic Beads with Highly Stable ZnO Nanorods for Biomarker Detection

High Precision Piezoelectric Micro Droplet Control and Generation System

Contact Info

Product

Resources

About