Heart rate and cardiovascular mortality: The Framingham study

Wb, Kannel; Kannel, C. E.; Rs, Paffenbarger; Cupples, L. Adrienne

doi:10.1016/0002-8703(87)90666-1

Cited by 1,187 publications

(822 citation statements)

References 11 publications

Supporting

Mentioning

722

Contrasting

Unclassified

Order By: Relevance

“…The increase in heart rate in the TFA group corresponds to approximately 3 bpm. A high heart rate is associated with an increased cardiovascular mortality (Kannel et al, 1987;Greenland et al, 1999;Reunanen et al, 2000). Furthermore, HRV indices associated with vagal cardiac modulation (RMSSD, pNN50, pNN6%) (Camm et al, 1996) were attenuated, although not significantly, after dietary supplementation with TFA.…”

Section: Discussionmentioning

confidence: 99%

Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

et al. 2004

View full text Add to dashboard Cite

Background: Studies of long-term intake of industrially produced trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (PUFA) suggest opposite effects on cardiovascular disease risk. Common mechanisms of action are probable. Objective: To examine the effects on cardiovascular risk markers of dietary enrichment with TFA or n-3 PUFA. Design: Randomized, double-blind, parallel intervention trial. Setting: Department of Human Nutrition, The Royal Veterinary and Agricultural University. Subjects: In all, 87 healthy males included, 79 completed. Intervention: Subjects were randomly assigned to 8 weeks of a daily intake of 33 g of experimental fats from either partially hydrogenated soy oil containing 20 g of TFA, 12 g of fish oil with approximately 4 g of n-3 PUFA and 21 g of control fat, or 33 g of control fat. The experimental fats were incorporated into bakery products. Plasma lipids, blood pressure, heart rate variability (HRV), arterial dilatory capacity, compliance, and distensibility were recorded before and after intervention and at follow-up 12 weeks after the intervention. Results: High-density lipoprotein cholesterol (HDL-C) decreased in the TFA group and triglycerides and mean arterial blood pressure decreased in the n-3 PUFA group compared to the control group. HRV, arterial dilatory capacity, compliance, and distensibility were unchanged. Conclusion:The results indicate that the association between coronary heart disease risk and intake of TFA and n-3 PUFA relates only modestly to changes in traditional risk markers.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

et al. 2004

View full text Add to dashboard Cite

show abstract

“…42 The Framingham Study in 1987 showed the heart rate to be related to the rate of development of cardiovascular and all-cause mortality in men, even taking into account other risk factors. 43 The relationship to sudden coronary fatalities was particularly strong with a linear increase with the heart rate. In the Framingham Study the association of the heart rate with cardiovascular mortality was also observed in the hypertensive segment of the population.…”

Section: Heart Ratementioning

confidence: 98%

Fifty years of Framingham Study contributions to understanding hypertension

2000

J Hum Hypertens

237

120

View full text Add to dashboard Cite

The Framingham Study established hypertension as a major cardiovascular risk factor and quantified its atherogenic cardiovascular disease potential. An historical perspective is presented on the epidemiological insights about hypertension derived from 50 years of Framingham Study research into the prevalence, incidence, determinants and hazards of hypertension. Existing misconceptions about the presence of critical levels of blood pressure, the impact of the systolic and diastolic components of blood pressure, the hazard 'mild' hypertension, the impact in advanced age and the hazard of left ventricular hypertrophy. The importance of isolated systolic hypertension and the pulse pressure were demonstrated. It has been demonstrated that hypertension seldom occurs in isolation of other athero-

show abstract

“…Increased resting heart rate (rHR), which is easily measurable in clinical practice, has been shown to be an independent risk factor for cardiovascular death in a nondiabetic population [13][14][15][16]. Recently, rHR has also been shown to be valuable in estimating the risk of cardiovascular death in patients with type 2 diabetes [8,10].…”

Section: Introductionmentioning

confidence: 99%

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis We evaluated the association of QT interval corrected for heart rate (QT c ) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes. Methods We followed 523 diabetic patients (221 with type 1 diabetes, 302 with type 2 diabetes) who were recruited between 1974 and 1977 in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes. Duration of follow-up was 22.6±0.6 years. Causes of death were obtained from death certificates, hospital records, post-mortem reports, and additional information given by treating physicians.

show abstract

Heart rate and cardiovascular mortality: The Framingham study

Cited by 1,187 publications

References 11 publications

Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

Fifty years of Framingham Study contributions to understanding hypertension

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

Contact Info

Product

Resources

About