Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

Spassov, Lubomir; Curzi‐Dascalova, Lilia; Clairambault, Jean; Kauffmann, F.; Eiselt, M.; Médigue, Claire; Peirano, Patricio

doi:10.1203/00006450-199404000-00022

Cited by 73 publications

(44 citation statements)

References 21 publications

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“…Our findings are consistent with the study of Spassov et al (1994), who found significantly decreased HRV in SGA neonates during sleep [28]. In contrast, our findings are not consistent with study of Schäffer et al (2008) [27].…”

Section: Discussionsupporting

confidence: 76%

Heart rate variability in low birth weight growth restricted children during sleep and wake stages

et al. 2013

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Intrauterine growth restricted (IUGR) individuals have greater predisposition to develop a metabolic syndrome in later life manifesting itself as obesity, hypertension, type 2 diabetes or cardiovascular disease. Poor fetal growth may alter the regularity mechanism of cardiac autonomic system that is involved in the development of these diseases. The malfunctioning of the cardiac autonomic system assessed by decrease in heart rate variability (HRV) is associated with negative cardiovascular outcomes. This study is aimed at investigating the risk of development of coronary heart disease in IUGR children in later life. For that purpose HRV analysis of normal and growth restricted children was performed during sleep and wake stages. The study group consisted of 9 to 10 years old, 32 normal, 20 low birth weight IUGR children. The standard time domain HRV metrics (mean RR, SDNN, RMSSD, NN50 and pNN50) and Poincaré indices (SD1 and SD2) were used to analyse and compare the RRinterval time series of these groups. The IUGR children showed lower HRV as compared with normal children during both sleep and wake stages. The significantly decreased HRV during sleep provide an evidence of autonomic derangement that may be associated with higher risk of lethal arrhythmias in the IUGR children in later life.

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Section: Discussionsupporting

confidence: 76%

Heart rate variability in low birth weight growth restricted children during sleep and wake stages

et al. 2013

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“…However, it is suggested that the association between lower birth weight and higher heart rate or higher sympathetic nerve activity is already present in early life. For example, Spassov et al (19) reported that heart rate was higher in newborn infants with small weight for gestational age compared to those with average weight for gestational age. Furthermore, Galland et al (20) reported that the sympathetic component of the control of heart rate variability was already higher in infants with low birth weight at 1 and 3 months of age.…”

Section: Discussionmentioning

confidence: 99%

Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood

et al. 2007

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There is substantial evidence that low birth weight is associated with the development of cardiovascular disease in adult life. Moreover, resting heart rate is a prognostic factor of cardiovascular morbidity and mortality. However, there are scarce data regarding the association between birth weight and resting heart rate in later life. Therefore, we investigated the association of anthropometric data at birth and hemodynamic indices including resting heart rate in Japanese boys. The data of 1,107 male students of a junior high school in Tokyo, Japan, who underwent a medical check-up in the year of admission to the school (12 or 13 years old) were used. Information on anthropometric data at birth based on "The Maternal and Child Health Handbook" was obtained from 573 students. From a standard 12-channel resting electrocardiogram, 8 cardiac cycles were used to estimate heart rate. Resting heart rate correlated positively with body mass index at the same age (r =0.100, p =0.017) and correlated negatively with birth weight (r =-0.102, p =0.015), height at birth (r =-0.125, p =0.003), and head circumference at birth (r =-0.095, p =0.025). The negative correlation of anthropometric data at birth with heart rate at the age of 12 or 13 was independent of body mass index at the same age. The mean value of resting heart rate at the age of 12 or 13 adjusted for body mass index at the same age was significantly higher in the lower tertile of birth weight than in the higher tertile of birth weight (81.7 vs. 78.5 beats/min, p =0.028). In conclusion, lower birth weight is associated with higher resting heart rate during boyhood, suggesting that elevated heart rate may be one mechanism linking small

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“…Since the first report on the use of heart rate variability parameters in 1978 [35], impaired variability was found in adult patients with myocardial infarction [18,21], left ventricular dysfunction [23,34], low cardiac output [17], chronic heart failure [23,28,33], panic disorder [36], and diabetic neuropathy [7]. A few reports are available in the pediatric literature on the heart rate behavior in premature infants [6,27], newborns [6,32], full-term infants at risk for sudden infant death syndrome [2,14,16,25,31], normal infants and children [10], diabetic children [1,20,22,38,39], children with atrial septal defect [9], and critically ill children following cardiac surgery [15]. Most of these reports compared a group of ill children with age-matched healthy children, so that well-documented normal ranges of heart rate variability for most parameters, to assess the behavior of the autonomic function during infancy and childhood, are not yet available.…”

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confidence: 99%

Normal Ranges of Heart Rate Variability During Infancy and Childhood

1997

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Heart rate variability is a noninvasive index of the neural activity of the heart. The present study examined heart rate variability indices in 210 infants and children aged 3 days to 14 years to obtain normal ranges for all age classes. Heart rate variability was measured by calculating mean RR interval over the length of the analysis, mean RR interval during quiet sleep, 5 time-domain (SDNN, SDNN-i, SDANN-i, r-MSSD, pNN50), and 4 frequency-domain (VLF, LF, HF, LF/HF ratio) indices. Our data show a significant positive correlation between all indices and the mean RR interval over the length of the analysis, except for the LF/HF ratio for which the correlation was binomial. A positive power correlation was also found between all parameters and age. The multiple correlation analysis confirmed the independent effect of age and mean RR interval on the heart rate variability. These data in a healthy pediatric population confirm a progressive maturation of the autonomic nervous system during childhood and may be utilized to examine the effects of underlying disease processes or therapeutic interventions on cardiac autonomic tone during infancy and childhood.

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Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

Cited by 73 publications

References 21 publications

Heart rate variability in low birth weight growth restricted children during sleep and wake stages

Heart rate variability in low birth weight growth restricted children during sleep and wake stages

Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood

Normal Ranges of Heart Rate Variability During Infancy and Childhood

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