2015
DOI: 10.1088/0967-3334/36/4/727
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Heart rate dynamics in doxorubicin-induced cardiomyopathy

Abstract: The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as e… Show more

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Cited by 33 publications
(25 citation statements)
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“…Our results are consistent with the results of the study by Lončar-Turukalo et al [31] which evaluated the influence of DOX treatment on the autonomic nervous system activity in healthy rats. In accordance with their study, it can be concluded that DOX treatment equally affects the regulation of the autonomic nervous system activity to the heart in healthy as well as in cancerous animals.…”
Section: Discussionsupporting
confidence: 93%
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“…Our results are consistent with the results of the study by Lončar-Turukalo et al [31] which evaluated the influence of DOX treatment on the autonomic nervous system activity in healthy rats. In accordance with their study, it can be concluded that DOX treatment equally affects the regulation of the autonomic nervous system activity to the heart in healthy as well as in cancerous animals.…”
Section: Discussionsupporting
confidence: 93%
“…Multigated acquisition scan (MUGA) and echocardiography are the most studied methods for the measurement of LVEF in humans; echocardiography was applied also in rats [31,37]. As LVEF measurements are very variable and insensitive [77] and the normal heart has a huge recruitable contractile potential [78], it is important to find other markers for the detection of early cardiac damage.…”
Section: Discussionmentioning
confidence: 99%
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“…In the present study, myocardial histopathology of HE staining from normal and cancer control mice showed normal architecture[24, 25]. However, DOX treatment resulted in chronic focal inflammatory pathology in the myocardium (Fig 2A).…”
Section: Resultsmentioning
confidence: 54%
“…The most common manifestations of the cardiotoxicity of doxorubicin are cardiac dysfunction and dilated cardiomyopathy. Moreover, the degree of damage to the heart depends on the dose and duration of doxorubicin administration (Chatterjee et al, 2010;Loncar-Turukalo et al, 2015;Mancilla et al, 2019). An application of this drug was also found to influence sensitivity of the heart to ischemic injury.…”
Section: Introductionmentioning
confidence: 99%