Heart rate: Predictor of cardiovascular risk

Ivanović, Branislava; Tadić, Marijana; Dinčić, Dragan

doi:10.2298/vsp1209799i

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…These recommendations point out the significance of resting heart rate as an independent predictor of cardiovascular morbidity and mortality in patients with arterial hypertension. [21].…”

Section: Heart Rate and Cardiovascular Mortalitymentioning

confidence: 99%

Fixed combination of bisoprolol and a low-dose hydrochlorothiazide in arterial hypertension

et al. 2018

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Beta-blockers showed better results in lowering elevated blood pressure in the younger age group of patients with higher renin plasma levels. Actual recommendations from the European Society of Cardiology for treatment of arterial hypertension from 2013 insist that heart rate should always be measured along with blood pressure. These recommendations point out the significance of resting heart rate as an independent predictor of cardiovascular morbidity and mortality in patients with arterial hypertension. Beta-blockers have a compelling indication for treatment of arterial hypertension in patients with coexistence of coronary artery disease, especially post myocardial infarction, as well as in patients with systolic heart failure. Bisoprolol, a highly selective beta-blocker with a long half-life and a prolonged antihypertensive effect, has shown consistent blood pressure control over a period of 24 hours. It has been demonstrated in placebo-controlled studies that administration of thiazide diuretics, in addition to lowering blood pressure levels, had also been associated with a reduction of cardiovascular morbidity and mortality rates. It is evident that effectiveness of thiazide diuretics is dose-dependent; however, undesirable effects of drugs are also dose-dependent. Depending on the dose, they aggravate glucose intolerance, increase lipid levels, cause hypokalemia, hyponatremia, and hypomagnesemia, and increase levels of uric acid. Administration of very low doses of a thiazide diuretic is acceptable in combination with other antihypertensive drugs, because it potentiates the action of other drugs without causing undesirable metabolic effects. The effectiveness and safety of the combination of bisoprolol (in various doses) and a thiazide diuretic in a small dose has been proven in clinical trials.

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“…These recommendations point out the significance of resting heart rate as an independent predictor of cardiovascular morbidity and mortality in patients with arterial hypertension. [21].…”

Section: Heart Rate and Cardiovascular Mortalitymentioning

confidence: 99%

Fixed combination of bisoprolol and a low-dose hydrochlorothiazide in arterial hypertension

et al. 2018

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“…[ 117 , 118 ] Lots of studies have demonstrated that the heart rate is a major independent cardiovascular risk factor for adverse prognosis. [ 119 ] Reduction of heart rate is the main effect of ivabradine and protects the myocardium against ventricular dysfunction induced by tachycardia. These effects can improve endothelial function, modulate immune cells and enhance a long-term adaptation in calcium handling.…”

Section: Treatmentsmentioning

confidence: 99%

Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis

Liu

Peng

et al. 2013

Burn Trauma

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Inflammation plays an important role in cardiac dysfunction under different situations. Acute systemic inflammation occurring in patients with severe burns, trauma, and inflammatory diseases causes cardiac dysfunction, which is one of the leading causes of mortality in these patients. Acute sepsis decreases cardiac contractility and impairs myocardial compliance. Chronic inflammation such as that occurring in Duchenne muscular dystropshy and myocarditis may cause adverse cardiac remodeling including myocyte hypertrophy and death, fibrosis, and altered myocyte function. However, the underlying cellular and molecular mechanisms for inflammatory cardiomyopathy are still controversial probably due to multiple factors involved. Potential mechanisms include the change in circulating blood volume; a direct inhibition of myocyte contractility by cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β); abnormal nitric oxide and reactive oxygen species (ROS) signaling; mitochondrial dysfunction; abnormal excitation-contraction coupling; and reduced calcium sensitivity at the myofibrillar level and blunted β-adrenergic signaling. This review will summarize recent advances in diagnostic technology, mechanisms, and potential therapeutic strategies for inflammation-induced cardiac dysfunction.

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Heart rate: Predictor of cardiovascular risk

Abstract: nem

Cited by 2 publications

References 26 publications

Fixed combination of bisoprolol and a low-dose hydrochlorothiazide in arterial hypertension

Fixed combination of bisoprolol and a low-dose hydrochlorothiazide in arterial hypertension

Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis

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