Heart rate recovery after exercise and its relation with neutrophil-to-lymphocyte ratio in patients with cardiac syndrome X

Yurtdaş, Mustafa; Yaylali, Yalın Tolga; Aladağ, Nesim; Özdemir, Mahmut; Ceylan, Yemlihan; Gençaslan, Murat; Akbulut, Tayyar

doi:10.1097/mca.0000000000000110

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…In contrast, patients with stable CAD had a lower mean NLR of 2.8 [8] compared with patients with STEMI. Patients with cardiac syndrome X had a mean NLR of 3.1 [20]. In a general population, the mean NLR was 2.2 [15].…”

Section: Discussionmentioning

confidence: 98%

Racial differences in the neutrophil-to-lymphocyte ratio in patients with non-ST-segment elevation myocardial infarction

Misumida¹,

Kobayashi²,

Kanei

2015

Coronary Artery Disease

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Section: Discussionmentioning

confidence: 98%

Racial differences in the neutrophil-to-lymphocyte ratio in patients with non-ST-segment elevation myocardial infarction

Misumida¹,

Kobayashi²,

Kanei

2015

Coronary Artery Disease

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“…Recent studies have shown that ratios of neutrophil and platelet counts to lymphocyte count (neutrophil-to-lymphocyte ratio, NLR and platelet-to-lymphocyte ratio, PLR) were potential inflammatory markers that are closely related to the prognosis of chronic inflammatory and cardiovascular diseases (4)(5)(6)(7)(8)(9)(10)(11)(12). In addition, NLR and PLR parameters were associated with C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) values that play an important role in the pathogenesis of HF (5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Mean Platelet Volume in Patients with Compensated Heart Failure

Yurtdaş¹,

Hastanesi²,

Özdemir³

et al. 2018

JAREM

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Objective: Inflammation plays an important role in the pathogenesis of cardiovascular diseases. Neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), and mean platelet volume (MPV) are associated with inflammation; therefore, we aimed to evaluate NLR, PLR, and MPV; investigate their association with each other in patients with compensated heart failure (HF) and compare it with that in controls; and search the predictive value of those markers in detecting the presence of HF.Methods: Between January 2016 and February 2017, 40 HF patients with left ventricular ejection fraction (LVEF) of <40% were enrolled in the study. The control group comprised 30 individuals with LVEF of ≥50% and no HF. The NLR, PLR, and MPV values were evaluated in all participants.Results: Neutrophil-to-lymphocyte ratio, PLR, and MPV were significantly higher in the HF group than those in the control group. In the patient group, there was a significant inverse correlation between LVEF and all inflammatory markers (for all, p<0.05), except for MPV. Inflammatory markers showed a significant positive relationship with each other (for all, p<0.05). Of all inflammatory markers, PLR was the only predictor of the presence of HF (OR, 1.015; 95% CI: 1.001-1.028; p=0.030). ROC curve analysis showed that the PLR value predicting the presence of HF was 73 with maximal sensitivity of 83% and specificity of 53% (UAC: 0.76; 95% CI: 0.65-0.88; p<0.001). Conclusion:Compared to those in the control group, NLR, PLR, and MPV were significantly higher and positively correlated to each other in the HF group. In addition, of those markers, only PLR could predict the presence of HF.

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“…A growing number of evidence in recent years has demonstrated that cardiac autonomic nervous activity, as evaluated by heart rate variability (HRV) and HRR, is associated with inflammatory markers [ 25 , 26 ]. More recently, we have shown that impaired cardiac autonomic function, as evidenced by a slower HRR, is closely related to inflammatory markers such as hsCRP in both CAD and cardiac syndrome X [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…HRR was described as the change in heart rate from peak exercise to 1 min after exercise. HRR of 12 beats/min or less was defined as abnormal [ 9 - 11 ]. In addition, the Duke treadmill score (DTS) was calculated for each participant according to the following formula: DTS = (exercise duration in minutes) - (5 × ST deviation in millimeters) - (4 × treadmill angina index).…”

Section: Methodsmentioning

confidence: 99%

Association of Heart Rate Recovery With Microalbuminuria in Non-Obstructive Coronary Artery Disease

Yurtdaş

Özdemir²,

Aladağ

et al. 2017

Cardiol Res

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BackgroundNon-obstructive coronary artery disease (CAD) is associated with significantly increased risk for myocardial infarction. Heart rate recovery (HRR), a measure of autonomic function, is a strong predictor of all-cause mortality. Microalbuminuria, a marker of early arterial disease, is an independent risk factor for cardiovascular disease and mortality. We aimed to investigate HRR and determine its relationship with microalbuminuria in patients with non-obstructive CAD.MethodsWe prospectively studied 565 patients who underwent elective coronary angiography. All participants underwent urinary analysis and then an exercise test. Microalbuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) of 30 - 299 mg/g. The HRR was abnormal if ≤ 12 beats/min during the first minute after exercise. First, all patients were divided into two groups, patients with microalbuminuria (n = 152) and patients without microalbuminuria (n = 413). Then, all patients were re-divided into two groups, those with lower HRR (≤ 12 beats/min, n = 126) and those with higher HRR (> 12 beats/min, n = 439).ResultsPatients with microalbuminuria had lower HRR and patients with lower HRR had higher UACR. While UACR was negatively correlated with HRR in patients with microalbuminuria (r = -0.424; P < 0.001) and in patients with lower HRR (r = -0.192; P= 0.042), there was no correlation of UACR with HRR in neither patients with normoalbuminuria nor patients with higher HRR, respectively. In the all study population, there was a significant inverse association between UACR and HRR (r = -0.445, P < 0.001), and UACR independently predicted the presence of lower HRR (P < 0.001).ConclusionsOur findings showed that there was a significant inverse association between UACR and HRR in patients especially with microalbuminuria, and that albuminuria might predict cardiac autonomic imbalance evaluated by HRR in patients with non-obstructive CAD.

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Heart rate recovery after exercise and its relation with neutrophil-to-lymphocyte ratio in patients with cardiac syndrome X

Abstract: CSX patients have higher NLR and PLR and slower HRR and lower DTS, similar to CAD patients, suggesting that CSX patients may be at a higher risk for developing cardiovascular events in the future. NLR may predict autonomic imbalance assessed by HRR in CSX.

Cited by 8 publications

References 26 publications

Racial differences in the neutrophil-to-lymphocyte ratio in patients with non-ST-segment elevation myocardial infarction

Racial differences in the neutrophil-to-lymphocyte ratio in patients with non-ST-segment elevation myocardial infarction

Investigation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Mean Platelet Volume in Patients with Compensated Heart Failure

Association of Heart Rate Recovery With Microalbuminuria in Non-Obstructive Coronary Artery Disease

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