Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice

Abstract

, "Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice," J. Biomed. Opt. Abstract. Traumatic brain injury (TBI) results in direct vascular disruption, triggering edema, and reduction in cerebral blood flow. Therefore, understanding the pathophysiology of brain microcirculation following TBI is important for the development of effective therapies. Optical coherence angiography (OCA) is a promising tool for evaluating TBI in rodent models. We develop an approach to OCA that uses the heart-rate frequency to discriminate between static tissue and vasculature. This method operates on intensity data and is therefore not phase sensitive. Furthermore, it does not require spatial overlap of voxels and thus can be applied to preexisting datasets for which oversampling may not have been explicitly considered. Heart-rate sensitive OCA was developed for dynamic assessment of mouse microvasculature post-TBI. Results show changes occurring at 5-min intervals within the first 50 min of injury. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

4-D Imaging of Beating Tissues Using Optical Coherence Tomography

“…Similar to reconstructing flow dynamics in retinal [16][17][18] and mouse brain [19] vasculatures, imaging hearts with cyclical motions is especially challenging for OCT -based techniques because of motion-caused artifacts decreasing image quality. In [20], Kang et al developed an accurate and fully automated algorithm to suppress the in-plane motion artifacts in OCT esophageal imaging.…”