Heart Rate Variability and Exceptional Longevity

Hernández-Vicente, Adrián; Hernando, David; Santos‐Lozano, Alejandro; Rodríguez-Romo, Gabriel; Vicente-Rodríguez, Germán; Pueyo, Esther; Bailón, Raquel; Garatachea, Nuria

doi:10.3389/fphys.2020.566399

Cited by 35 publications

(29 citation statements)

References 52 publications

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“…An additional goal of the current study was to explore the influence of acute CBD ingestion on heart rate variability, the inconsistencies in the periods of time separating consecutive cardiac cycles. It is an important predictor of future cardiac events [14,15] and, in some instances, longevity [16]. While there are many methods and different parameters used to quantify heart rate variability, generally speaking, greater variability is considered desirable.…”

Section: Discussionmentioning

confidence: 99%

“…Heart rate variability refers to the inconsistency within the periods of time separating consecutive cardiac cycles. It is considered to have clinical relevance as it is able to predict future cardiac events and mortality [14][15][16]. To our knowledge, only one other study has examined the influence of CBD (specifically, a hemp-oil extract containing CBD) on heart rate variability in adult humans [17], and this study reported on short-term CBD use (3 and 6 weeks) and not an acute response.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

et al. 2021

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Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are conflicting. Differences between CBD preparations and bioavailability may contribute to these discrepancies. Further, an influence of body composition on CBD bioavailability is feasible, but currently undocumented. The aims of this study were to: (1) compare the pharmacokinetics of five oral CBD preparations over 4 h; (2) examine the relationship between body composition and CBD pharmacokinetics; and, (3) explore the influence of CBD on heart rate variability. In total, five preparations of CBD, standardized to 30 mg, were orally administered to 15 healthy men and women (21–62 years) in a randomized, crossover design. Prior to and 60 min following CBD ingestion, heart rate variability was determined. Body composition was assessed using dual energy X-ray absorptiometry. Peak circulating CBD concentration, time to peak concentration, and area under the curve was superior in a preparation comprising 5% CBD concentration liquid. Fat free mass was a significant predictor (R2 = 0.365, p = 0.017) of time to peak concentration for this preparation. Several heart rate variability parameters, including peak frequency of the high frequency band, were favorably, but modestly modified following CBD ingestion. These data confirm an influence of CBD preparation and body composition on CBD bioavailability, and suggest that acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

et al. 2021

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“…Further support to this view comes from the observation that increased vagally mediated HRV has been described in centenarians compared with old adults ( Piccirillo et al, 1998 ; Paolisso et al, 1999 ), suggesting that the maintenance of a sound vagal tone may be crucial for successful aging and longevity ( Hernandez-Vicente et al, 2020 ). It must be noted, however, that other studies have shown that increased vagally mediated HRV may also predict cardiac mortality in elderly populations ( Dekker et al, 1997 ; de Bruyne et al, 1999 ).…”

Section: Introductionmentioning

confidence: 98%

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

et al. 2021

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ObjectiveThe aim of this study was to assess age-related changes in cardiac autonomic modulation and heart rate variability (HRV) and their association with spontaneous and pharmacologically induced vulnerability to cardiac arrhythmias, to verify the translational relevance of mouse models for further in-depth evaluation of the link between autonomic changes and increased arrhythmic risk with advancing age.MethodsHeart rate (HR) and time- and frequency-domain indexes of HRV were calculated from Electrocardiogram (ECG) recordings in two groups of conscious mice of different ages (4 and 19 months old) (i) during daily undisturbed conditions, (ii) following peripheral β-adrenergic (atenolol), muscarinic (methylscopolamine), and β-adrenergic + muscarinic blockades, and (iii) following β-adrenergic (isoprenaline) stimulation. Vulnerability to arrhythmias was evaluated during daily undisturbed conditions and following β-adrenergic stimulation.ResultsHRV analysis and HR responses to autonomic blockades revealed that 19-month-old mice had a lower vagal modulation of cardiac function compared with 4-month-old mice. This age-related autonomic effect was not reflected in changes in HR, since intrinsic HR was lower in 19-month-old compared with 4-month-old mice. Both time- and frequency-domain HRV indexes were reduced following muscarinic, but not β-adrenergic blockade in younger mice, and to a lesser extent in older mice, suggesting that HRV is largely modulated by vagal tone in mice. Finally, 19-month-old mice showed a larger vulnerability to both spontaneous and isoprenaline-induced arrhythmias.ConclusionThe present study combines HRV analysis and selective pharmacological autonomic blockades to document an age-related impairment in cardiac vagal modulation in mice which is consistent with the human condition. Given their short life span, mice could be further exploited as an aged model for studying the trajectory of vagal decline with advancing age using HRV measures, and the mechanisms underlying its association with proarrhythmic remodeling of the senescent heart.

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“…Optimism is associated with a 11-15% longer lifespan and greater odds for achieving "exceptional longevity" (Lee et al, 2019). Vagal function may play a mediating role in these longevity outcomes (Zulfiqar et al, 2010;Kemp et al, 2017a,b;Hernández-Vicente et al, 2020).…”

Section: The Individual Domain and Wellbeingmentioning

confidence: 99%

Moving Beyond Disciplinary Silos Towards a Transdisciplinary Model of Wellbeing: An Invited Review

2021

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The construct of wellbeing has been criticised as a neoliberal construction of western individualism that ignores wider systemic issues such as inequality and anthropogenic climate change. Accordingly, there have been increasing calls for a broader conceptualisation of wellbeing. Here we impose an interpretative framework on previously published literature and theory, and present a theoretical framework that brings into focus the multifaceted determinants of wellbeing and their interactions across multiple domains and levels of scale. We define wellbeing as positive psychological experience, promoted by connections to self, community and environment, supported by healthy vagal function, all of which are impacted by socio-contextual factors that lie beyond the control of the individual. By emphasising the factors within and beyond the control of the individual and highlighting how vagal function both affects and are impacted by key domains, the biopsychosocial underpinnings of wellbeing are explicitly linked to a broader context that is consistent with, yet complementary to, multi-levelled ecological systems theory. Reflecting on the reciprocal relationships between multiple domains, levels of scale and related social contextual factors known to impact on wellbeing, our GENIAL framework may provide a foundation for a transdisciplinary science of wellbeing that has the potential to promote the wellbeing of individuals while also playing a key role in tackling major societal challenges.

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Heart Rate Variability and Exceptional Longevity

Cited by 35 publications

References 52 publications

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Moving Beyond Disciplinary Silos Towards a Transdisciplinary Model of Wellbeing: An Invited Review

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