Heart Rate Variability and Omega-3 Index in Euthymic Patients with Bipolar Disorders

Voggt, Alessandra; Berger, Michael; Obermeier, Michael; Low, A. G.; Seemueller, Florian; Riedel, Michael; Zimmermann, René; Kirchberg, Franca F.; Schacky, Clemens von; Severus, Emanuel

doi:10.1016/j.eurpsy.2014.11.010

Cited by 18 publications

(7 citation statements)

References 39 publications

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“…Parameters were calculated from a 30 min ECG recording, with SD of R–R interval (SDNN), low frequency (LF) power and high frequency (HF) power found to be lower in the BD group. 17 In 2012, Levy used several physiological measures of autonomic nervous system function to determine differences between patients with BD and healthy controls, without using the traditional HRV features. Thirty-three patients with BD and 22 healthy controls had 5 min of ECG recorded at rest, with significant differences found in physiological HR features between patients with BD and healthy controls.…”

Section: Presentationmentioning

confidence: 99%

Heart rate variability in bipolar disorder and borderline personality disorder: a clinical review

Carr

Vos

Saunders

2017

Evid Based Mental Health

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Heart rate variability (HRV) in psychiatric disorders has become an increasing area of interest in recent years following technological advances that enable non-invasive monitoring of autonomic nervous system regulation. However, the clinical interpretation of HRV features remain widely debated or unknown. Standardisation within studies of HRV in psychiatric disorders is poor, making it difficult to reproduce or build on previous work. Recently, a Guidelines for Reporting Articles on Psychiatry and Heart rate variability checklist has been proposed to address this issue. Here we assess studies of HRV in bipolar disorder and borderline personality disorder against this checklist and discuss the implication for ongoing research in this area.

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Section: Presentationmentioning

confidence: 99%

Heart rate variability in bipolar disorder and borderline personality disorder: a clinical review

Carr

Vos

Saunders

2017

Evid Based Mental Health

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“…More recently, Voggt et al (2015) used 30-minute ECG recordings in 90 predominantly medicated bipolar I and II subjects combined, deemed ‘ clinically stable ’, and 62 healthy control subjects, to measure differences in HRV. They found that the SDNN, LF and HF parameters were lower in the bipolar subjects.…”

Section: Hrv and Euthymia In Bipolar Disordersmentioning

confidence: 99%

A literature review of heart rate variability in depressive and bipolar disorders

Bassett

2015

Aust N Z J Psychiatry

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Objective: Autonomic nervous system dysfunction has the potential to adversely impact general medical health and is known to exist in a number of psychiatric disorders. It reflects alterations in the function of several regions of the central nervous system. Measurement of heart rate variability provides a non-invasive tool for studying autonomic function. While the literature relating to the technical process of heart rate variability and aspects of depressive disorders has been reviewed in the past, research relating to both depressive and bipolar disorders has not been comprehensively reviewed. This paper critically considers the published research in heart rate variability in both depressive and bipolar affective disorders. Method:A literature search using Medline, EMBASE, PsycINFO, ProQuest Psychology and references included in published literature was conducted using the following keywords: 'heart rate variability and autonomic, combined with depression, depressive disorder, bipolar, mania and sleep'. Results:The evidence demonstrates that, using heart rate variability measures, significant distortions of autonomic function are evident in both depressive and bipolar disorders and from most of their pharmacological treatments. Conclusion:The autonomic dysfunction evident in both unipolar and bipolar affective disorders, and many psychotropic medications, has significant implications for our understanding of the neurophysiology of these disorders, their treatment and associated general health.

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“…A reduced HRV has been found to predict an adverse prognosis in the general population, and is a strong and independent predictor of mortality after an acute myocardial infarction (Algra et al, 1993; Kleiger et al, 1987; Rennie et al, 2003). Several lines of evidence indicate autonomous dysfunction in bipolar disorder (Levy, 2013; Wang et al, 2016), and HRV has been found reduced during different affective states in patients with bipolar disorder compared with healthy control subjects in individual studies (Chang et al, 2014, 2015; Clarke, 2015; Cohen et al, 2003; Gruber et al, 2015; Henry et al, 2010; Lee et al, 2012; Levy, 2014; Moon et al, 2013; Quintana et al, 2015; Voggt et al, 2015). In the first focused systematic review and meta-analysis of HRV in bipolar disorder, we recently found support for a reduced HRV in patients with bipolar disorder compared with healthy control individuals although several methodological issues in individual studies limiting the evidence were identified (Faurholt-Jepsen et al).…”

Section: Introductionmentioning

confidence: 99%

State-related differences in heart rate variability in bipolar disorder

Faurholt‐Jepsen

Brage

Kessing

et al. 2017

Journal of Psychiatric Research

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Heart rate variability (HRV) is a validated measure of sympato-vagal balance in the autonomic nervous system. HRV appears decreased in patients with bipolar disorder (BD) compared with healthy individuals, but the extent of state-related alterations has been sparingly investigated. The present study examined differences in HRV between affective states in BD. A heart rate and movement sensor weighing 8 g collected average acceleration, heart rate and the two slowest and fastest heart beats (of the most recent 16 beats) every 30 s over a period of at least three consecutive weekdays and nights in a prospective longitudinal design from a total of 31 different affective states in 16 outpatients with BD. A proxy measure of HRV was calculated as the difference between the second-shortest and the second-longest inter-beat-interval collected during each of the epochs. Analyses were based on over 100.000 HRV data-points. In unadjusted analyses and in analyses adjusted for age, gender and heart rate, during a manic state HRV was increased by 18% compared with a depressed state (e = 1.18, 95% CI: 1.16-1.20, p < 0.001) and increased by 17% compared with a euthymic state (e = 1.17, 95% CI: 1.15-1.19, p < 0.001), whereas there was no difference between a depressive state and a euthymic state (e = 0.98, 95% CI: 0.96-1.00, p = 0.12). Further inclusion of BMI as a covariate did not alter any of the associations. HRV appears to be altered in a state-dependent manner in bipolar disorder and could represent a candidate state marker. Further studies with larger sample sizes are warranted.

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Heart Rate Variability and Omega-3 Index in Euthymic Patients with Bipolar Disorders

Cited by 18 publications

References 39 publications

Heart rate variability in bipolar disorder and borderline personality disorder: a clinical review

Heart rate variability in bipolar disorder and borderline personality disorder: a clinical review

A literature review of heart rate variability in depressive and bipolar disorders

State-related differences in heart rate variability in bipolar disorder

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