Heart rate variability and vagal tone in schizophrenia: A review

Montaquila, Julian M.; Trachik, Benjamin; Bedwell, Jeffrey S.

doi:10.1016/j.jpsychires.2015.07.025

Cited by 83 publications

(69 citation statements)

References 69 publications

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“…Specifically, parasympathetic nervous system (PNS) activity was reduced in patients with schizophrenia [2,3]. Our research has shown that high doses of antipsychotic medication can affect ANS function in patients with schizophrenia [7], and previous studies have also demonstrated that antipsychotic medication affects ANS activity in such patients [8,9,10,11,12,13].…”

Section: Introductionmentioning

confidence: 97%

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Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics

Miyauchi

Kishida²,

Suda³

et al. 2016

Neuropsychobiology

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Background: Patients with schizophrenia have abnormal autonomic nervous system (ANS) activity compared with the general population. One reason for this difference is the muscarinic affinity for antipsychotic drugs; therefore, single nucleotide polymorphisms (SNPs) of the muscarinic receptor gene influence this ANS dysfunction. This study sought to determine the effect of SNPs of the cholinergic muscarinic receptor (CHRM) gene on ANS activity in patients with schizophrenia receiving antipsychotic drugs. Methods: A total of 173 Japanese patients with schizophrenia were included in this study. Heart rate variability (HRV) was measured as an index of ANS activity. SNPs in CHRM1 (rs542269 and rs2075748), CHRM2 (rs324640, rs8191992, rs1824024, and rs7810473), and CHRM3 (rs3738435, rs4620530, and rs6429157) were genotyped using the TaqMan® method. Patients were grouped according to standard equivalent conversions of chlorpromazine (CP) into a high-CP group (HG; ≥1,000 mg) and a low-CP group (LG; <1,000 mg). ANS activity was compared between the groups. In addition, we compared the total, low-frequency (LF), high-frequency (HF), and LF/HF components of the patients' HRV, and the genotype of the SNPs in both the HG and LG groups. Bonferroni correction was applied for multiple comparisons, and the Bonferroni-corrected critical p value was <0.005. Results: The A allele of the CHRM2 rs8191992 polymorphism in HG was associated with decreased ANS activity. Conclusion: Our results show reduced ANS activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia.

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Section: Introductionmentioning

confidence: 97%

“…Autonomic nervous system (ANS) activity in patients with schizophrenia is abnormal compared with that of the general population [1,2,3,4,5,6]. Specifically, parasympathetic nervous system (PNS) activity was reduced in patients with schizophrenia [2,3].…”

Section: Introductionmentioning

confidence: 99%

Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics

Miyauchi

Kishida²,

Suda³

et al. 2016

Neuropsychobiology

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“…In SZ, reduced HRV has been found, suggesting a constant perception of threat that leads to the maintenance of an overall elevated sympathetic arousal and decrease parasympathetic activity [81]. In keeping with these results, paranoid patients are more likely to attribute threat to ambiguous stimuli [81]. To our knowledge, no studies have investigated HRV in patients with SZ when exposed to emotional faces.…”

Section: Future Directionsmentioning

confidence: 76%

“…For example, heart-rate variability (HRV) is linked to emotional processing in healthy individuals [80]. In SZ, reduced HRV has been found, suggesting a constant perception of threat that leads to the maintenance of an overall elevated sympathetic arousal and decrease parasympathetic activity [81]. In keeping with these results, paranoid patients are more likely to attribute threat to ambiguous stimuli [81].…”

Section: Future Directionsmentioning

confidence: 78%

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

Grave¹,

Soares²,

Martins³

et al. 2017

IJCNMH

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Schizophrenia is one of the most severe psychiatric conditions, often associated with deficits in social cognition. Social cognition deficits are predictors of functionality in patients and involve theory of mind, attributional style, social perception, and emotional processing. In particular, facial emotion processing (an important domain of emotional processing) seems to be particularly related to cognitive and social functioning, and to positive and negative symptoms. Patients with schizophrenia have difficulties in processing emotional faces; however, those impairments are still far from fully understood. In this review, we addressed the behavioural and neural correlates of facial emotion processing in schizophrenia. Despite studies showing impairments in both positive and negative faces, the most consistent findings involved negative faces. Moreover, patients with schizophrenia showed abnormalities in the social brain neural circuit during facial emotion processing. While some studies described hypoactivation of brain areas related to emotional processing, such as the amygdala, others reported hyperactivation, leading to a high number of inconsistencies. The findings are limited by the experimental designs used, and the clinical and demographic characteristics of patients. Despite such variable findings, there has been growing interest in developing psychosocial interventions focused directly on social cognitive impairments in schizophrenia, with potential impact on patient's ability to perceive emotional faces. We provide a critical perspective on current evidence and suggest new pathways of research. The understanding of the mechanisms underlying facial emotion processing in schizophrenia could enhance functionality and quality of life by providing innovative approaches to the interpersonal difficulties patients frequently experience.

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“…hERG gene) related to potassium channels and their regulation. Other mechanisms might be associated with alteration of dopamine D2 receptor signalling in the heart or with imbalance of autonomic nervous system, particularly with reduced efferent vagal activity [6] leading to abnormalities in heart rate variability [7].…”

Section: Discussionmentioning

confidence: 99%