Heart rate variability as a transdiagnostic biomarker of psychopathology

Beauchaine, Theodore P.; Thayer, Julian F.

doi:10.1016/j.ijpsycho.2015.08.004

Cited by 685 publications

(631 citation statements)

References 179 publications

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“…It also is possible that the relatively low internal consistency of the self-report measures, particularly the MAQ, obscured or attenuated some relationships that truly exist, despite the use of the principal component analysis to reduce the noise associated with any given measure. Finally, although the present study evaluated risk for depression, RSA, PC, and decentering represent promising transdiagnostic factors that may be implicated in other types of psychopathology, including anxiety disorders (Beauchaine & Thayer, 2015; Bernstein et al, 2015; Nolen-Hoeksema et al, 2008; Watkins, 2008). …”

Section: Discussionmentioning

confidence: 99%

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Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study

Stange

Hamilton

Fresco

et al. 2017

Behaviour Research and Therapy

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Depression often is characterized by inflexible autonomic and metacognitive processes that interfere with effective self-regulation. However, few studies have integrated these factors to improve the prediction of which individuals are at greatest risk for depression. Among 134 undergraduates, we evaluated whether parasympathetic inflexibility (a lack of reduction in respiratory sinus arrhythmia) in response to a sadness induction involving loss would prospectively predict symptoms of depression across four waves of follow-up over twelve weeks. Furthermore, we evaluated whether metacognitive components of perseverative cognition (PC) and decentering (identified by a principal component analysis) would moderate this relationship in opposite directions. Multilevel modeling demonstrated that the relationship between parasympathetic inflexibility and prospective symptoms of depression was exacerbated by PC, but attenuated by decentering. Furthermore, individuals with parasympathetic inflexibility, PC, and low decentering were at greatest risk for symptoms of depression across follow-up. These results support the utility of integrating autonomic and metacognitive risk factors to identify individuals at risk for depression.

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Section: Discussionmentioning

confidence: 99%

“…RSA has been proposed as a biological index of the capacity for effective emotion regulation (Beauchaine & Thayer, 2015; Thayer et al, 2012). Indeed, extensive literature has documented that lower levels of RSA at rest are associated with maladaptive emotion regulation and MDD (Kemp et al, 2010; Rottenberg, 2007).…”

mentioning

confidence: 99%

Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study

Stange

Hamilton

Fresco

et al. 2017

Behaviour Research and Therapy

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“…There is a functional interaction between vagal HRV and motivational systems in behavioral maladjustments. Therefore, vagal HRV can be used as a transdiagnostic biomarker of self-regulation and cognitive control (Beauchaine & Thayer, 2015).…”

Section: Startle Modulation and Cardiac Vagal Controlmentioning

confidence: 99%

Individual differences in behavioral activation and cardiac vagal control influence affective startle modification

Yang

Friedman

2017

Physiology & Behavior

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“…Chronic reductions in vagal activity indexed by HRV are associated with poor physiological, emotional, cognitive, behavioral regulation and self-rated heath (Alvares et al 2013; Beauchaine and Thayer 2015; Jarczok et al 2015; Thayer and Lane 2000; Thayer et al 2012; Thayer et al 2009a; Thayer and Lane 2009), as well as psychopathology (Kemp et al 2010; Koenig et al 2015, 2016; Clamor et al 2016). Functional neuroimaging studies and human lesion studies have shown several brain regions and networks involved in the neural control of HRV (Thayer et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples

et al. 2017

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Previous research has shown associations between brain structure and resting state high-frequency heart rate variability (HF-HRV). Age affects both brain structure and HF-HRV. Therefore we sought to examine the relationship between brain structure and HF-HRV as a function of age. Data from two independent studies were used for the present analysis. Study 1 included 19 older adults (10 males, age range 62–78 years) and 19 younger adults (12 males, age range 19–37). Study 2 included 23 older adults (12 males; age range 55–75) and 27 younger adults (17 males; age range 18–34). The root-mean-square of successive R-R-interval differences (RMSSD) from ECG recordings was used as time-domain measure of HF-HRV. MRI scans were performed on a 3.0-T Siemens Magnetom Trio scanner. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suite, including 12 regions as regions-of-interests (ROI). Zero-order and partial correlations were used to assess the correlation of RMSSD with cortical thickness in selected ROIs. Lateral orbitofrontal cortex (OFC) cortical thickness was significantly associated with RMSSD. Further, both studies, in line with previous research, showed correlations between RMSSD and anterior cingulate cortex (ACC) cortical thickness. Meta-analysis on adjusted correlation coefficients from individual studies confirmed an association of RMSSD with the left rostral ACC and the left lateral OFC. Future longitudinal studies are necessary to trace individual trajectories in the association of HRV and brain structure across aging.

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Heart rate variability as a transdiagnostic biomarker of psychopathology

Cited by 685 publications

References 179 publications

Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study

Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study

Individual differences in behavioral activation and cardiac vagal control influence affective startle modification

Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples

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