Heart rate variability assessment in Japanese workers recovered from depressive disorders resulting from job stress: measurements in the workplace

Takada, Mikio; Ebara, Takeshi; Kamijima, Michihiro

doi:10.1007/s00420-009-0499-1

Cited by 31 publications

(30 citation statements)

References 42 publications

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“…However, the complexity of the relationship between HR and HRV, and the known influence of respiration on HRV indices, led us to hypothesize that these discrepant results may be due to a weakness in the application of HRV when applied to studies with long-term data collection and without the use of controlled respiration. The available data from the literature on the effect of stress on HRV in animals are controversial, and the effects are usually assessed during or shortly after stress; on the other hand, long-term HRV disturbances are described in chronically stressed humans (12,29). We speculate that the sustained vagal activation observed after subchronic foot shock exposure may be a transient compensatory phenomenon that initially overcomes the commonly observed stress-induced sympathetic hyperactivity, and thus is a sign of adaptation.…”

Section: Discussionmentioning

confidence: 88%

Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats

Carnevali

Bondarenko

Sgoifo

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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In humans, chronic stressors have long been recognized as potential causes for cardiac dysregulation. Despite this, the underlying mechanistic links responsible for this association are still poorly understood. The purpose of this study was to determine whether exposure to a paradigm of subchronic stress can provoke enduring changes on the heart rate of experimental rats and, if so, to reveal the autonomic and neural mechanisms that mediate these effects. The study was conducted on adult male Sprague-Dawley rats instrumented for telemetric recording of heart rate and locomotor activity. Animals were submitted to a subchronic stress protocol, consisting of a 1-h foot shock session on five consecutive days. Heart rate and locomotor activity were recorded continuously for 3 days before and for 6 days after the subchronic stress period. Subchronic foot shock produced significant and enduring reduction in heart rate both during the dark/active [Δ= -23 ± 3 beats per minute (bpm)] and light/inactive (Δ= -20 ± 3 bpm) phases of the circadian cycle, and a reduction in locomotor activity during the dark/active phase [Δ= -54 ± 6 counts per hour (cph)]. The bradycardic effect of subchronic stress was not related to a reduced locomotion. Selective sympathetic (atenolol) and vagal (methyl-scopolamine) blockades were performed to reveal which autonomic component was responsible for this effect. We found that the fall in heart rate persisted after subchronic stress in animals treated with atenolol (active phase Δ= -16 ± 3 bpm, inactive phase Δ= -19 ± 2 bpm), whereas vagal blockade with scopolamine transiently prevented this effect, suggesting that the bradycardia following subchronic stress was predominantly vagally mediated. Fluoxetine (selective serotonin reuptake inhibitor) and metyrapone (inhibitor of corticosterone synthesis) treatments did not affect heart rate changes but prevented the reduction in locomotion. We conclude that subchronic stress exposure in rats reduces heart rate via a rebound in vagal activation and that this effect is serotonin- and corticosterone-independent.

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Section: Discussionmentioning

confidence: 88%

Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats

Carnevali

Bondarenko

Sgoifo

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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“…For recording and analyses of the A-A intervals, an Artett acceleration plethysmography system (U-Medica, Osaka, Japan) was utilised for analyses of the data, as described earlier. 4 From the low-frequency power (LF; 0.02-0.15 Hz) and the high-frequency power (HF; 0.15-0.50 Hz), the ratio of LF to HF power (LF/HF) was calculated using the maximal entropy method (MEM). The mean of two values from MEM was used.…”

Section: Testing Of Autonomic Functionsmentioning

confidence: 99%

Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study

et al. 2013

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ObjectiveThe purpose of this study is to investigate the usefulness of sympathetic skin response (SSR) and heart rate variability (HRV) for the differential diagnosis of patients with dementia with Lewy bodies (DLB).DesignA diagnostic test study.SettingSingle centre in Japan.ParticipantsWe examined 20 patients with probable Alzheimer's disease (AD) diagnosed with NINCDS-ADRDA criteria and 20 with probable DLB diagnosed with the criteria of the third international DLB workshop.MethodsFor the SSR measurement, surface electrodes were used: the active recording electrode was placed on the palm of the hand and the reference electrode was placed on the dorsum of the same hand. SSR was induced by a median nerve electrical stimulation at an amplitude of 20 mA. For the HRV measurement, the A–A intervals were measured twice for 2 min with an interval of 5 min in a sitting position after a rest of 5 min. From the low-frequency power (LF; 0.02–0.15 Hz) and high-frequency power (HF; 0.15–0.50 Hz), the ratio of LF to HF power (LF/HF) was calculated using the maximal entropy method.ResultsSSR and HRV could detect the abnormality of autonomic function in patients with DLB at sensitivities of 85% and 90%, respectively. On the other hand, SSR and HRV detected an abnormality of autonomic function in patients with AD at sensitivities of 15% and 25% (p<0.05). The combination of the SSR and the HRV (double-positive) indicated abnormal autonomic function was recorded in only 1 of 20 patients (5%) with AD. In contrast, this combination indicated autonomic abnormality in 15 of 20 patients with DLB by our criteria (75%).ConclusionsSSR and HRV can be applied to differentiate DLB from AD.

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“…15 4 study in Japanese worker suffering from job stress and he proved that HF was considerably lower in stressed group and when this group was given treatment, their HF increased which showed that stress was associated with vagal withdrawl. 16 Kemp et al, (2012) also showed decrease in HF in depressed subjects due to vagal withdrawl. 17 Decrease in HF and increase in low frequency in the current study proves that stress is associated with parasympathetic withdrawal as shown by decrease in HF in stressed subjects and sympathetic dominance depicted by increased LF and LF/HF ratio in stressed subjects.…”

Section: Discussionmentioning

confidence: 95%

Stress Response; Psychologically Stressed and Control Subjects; Comparison of Autonomic and Neuro Endocrine Response

Jawwad¹,

Khan

Ali

2017

TPMJ

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Heart rate variability assessment in Japanese workers recovered from depressive disorders resulting from job stress: measurements in the workplace

Cited by 31 publications

References 42 publications

Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats

Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats

Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study

Stress Response; Psychologically Stressed and Control Subjects; Comparison of Autonomic and Neuro Endocrine Response

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