Heart Rate Variability-Based Prediction of Autonomic Dysreflexia After Spinal Cord Injury

Calderón-Juárez, Martín; Miller, Tiev; Samejima, Soshi; Shackleton, Claire; Malik, Raza N.; Sachdeva, Rahul; Dorey, Tristan W.; Krassioukov, Andrei V.

doi:10.1089/neu.2023.0583

Cited by 3 publications

(1 citation statement)

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“…AD can result in a wide range of outcomes, from asymptomatic or mild discomfort cases to intracerebral haemorrhage or death [ 10 ]. Therefore, monitoring cardiac autonomic function after SCI is crucial and may be useful in clinical practice for predicting the development of autonomic dysfunction (including AD) and identifying patients at high risk for cardiac complications [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Diurnal variation of heart rate variability in individuals with spinal cord injury

Saengsuwan,

Ruangsuphaphichat,

Brockmann

et al. 2024

BioMed Eng OnLine

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Background Heart rate variability (HRV) may provide objective information about cardiogenic autonomic balance in individuals with spinal cord injury (SCI). The aim of this study was to characterize the diurnal variation of HRV in individuals with SCI at lesion level T6 and above and lesion level below T6. Methods This was a retrospective analysis of a prior cross-sectional study. Individuals with chronic SCI underwent 24 h recording of the time between consecutive R waves (RR interval) to derive parameters of HRV as follows: standard deviation of all normal-to-normal R–R intervals (SDNN) and square root of the mean of the squared differences between successive R–R intervals (RMSSD) (time domain); and high frequency power (HF), low-frequency power (LF), very low frequency power (VLF), ultra-low frequency power (ULF) and total power (TP) (frequency domain). Changes in the magnitude of HRV outcomes over the 24 h period were investigated using a novel multi-component cosinor model constrained to the form of a three-harmonic Fourier series. Results Participants were grouped as lesion level T6 and above (n = 22) or below T6 (n = 36). Most of them were male (n = 40, 69%) and the median age (interquartile range) was 50.5 (28) years. Both groups exhibited similar diurnal patterns in most HRV metrics. The lowest values occurred in the late afternoon (4–6 pm) and gradually increased, peaking around midnight to early morning (1–6 am). Exceptions included RMSSD, which peaked before midnight, and ULF, which showed a double peak pattern that peaked from 11 am to 1 pm and 4–6 am in participants with lesion level at T6 and above. The HRV values in participants with lesion level T6 and above were generally lower than participants with lesion level below T6, except for peak values of RMSSD, HF and LF. Conclusion This study demonstrated substantial diurnal variation of HRV in participants with SCI in both groups of participants. In clinical and research settings, diurnal variations in HRV must be taken into consideration.

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Section: Introductionmentioning

confidence: 99%