Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV

Stróżecki, Paweł; Polak, Gwidon; Manitius, Jacek

doi:10.1093/ndt/gfn481

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The above time and frequency domain indices are widely used to evaluate the correlations between HRV indices and pathological/physiological measurements from patients with different kinds of diseases, ex. kidney failure [5], diabetic neuropathy [6], sepsis and septic shock [9].…”

Section: A Hrv Parametersmentioning

confidence: 99%

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Cardiac autonomic neuropathy evaluated by time asymmetric analysis for heart rate variability in patients with peritoneal dialysis

Lee

Ting

Tseng

et al. 2010

TENCON 2010 - 2010 IEEE Region 10 Conference

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In this study we attempt to quantify the correlations between time asymmetric index (TAI) and physiological/ pathological measurements in order to predict the status of cardiac autonomic neuropathy (CAN) in patients with end-stage renal disease. The TAI can explore non-equilibrium dynamics that conventional time and frequency domain indices fail to consider. For comparing the effectiveness and applicability, traditional time-domain and frequency-domain heart rate variability (HRV) indices were also evaluated.To validate the use of TAI, this study investigates 65 DM patients (22 men and 43 women) and divides the data into two subgroups by HbA1c. The HRV indices such as PNN50 and nLF exhibit a positive correlation with CTR in HbA1c+ subgroup, while SDANN and nLHR show a positive correlation between P and Caphos, respectively. In particular, TAI exhibits a significant negative correlation with TNF-alpha, HbA1c, Caphos, and GLUAC in HbA1c+ subgroup, which overcomes the limitation that a single index can be only correlated to one measurement for conventional time-domain and frequency-domain HRV indices. These results manifest that TAI is an integrated HRV index that contains more information than traditional HRV analysis. Moreover, TAI provides a useful and quantified method in evaluation of the cardiac autonomic neuropathy in patients with ESRD. A large cohort study with TAI analysis is in need for potential cardiovascular outcome prediction. Keywords-TAI; heart rate variability, cardiac autonomic neuropathy, end-stage renal diseaseI.

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Section: A Hrv Parametersmentioning

confidence: 99%

“…Besides, the sensitivity and specificity is low, which also restricted the clinical use of heart rate variability. Recently, there are new advance in computation of heart rate variability, which take non-linear concept into this field [4] [5]. There are few data to discuss the association in patients with ESRD.…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic neuropathy evaluated by time asymmetric analysis for heart rate variability in patients with peritoneal dialysis

Lee

Ting

Tseng

et al. 2010

TENCON 2010 - 2010 IEEE Region 10 Conference

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Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients

et al. 2017

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BackgroundVascular access (VA) is the lifeline of hemodialysis patients. Although the autonomic nervous system might be associated with VA failure (VAF), it has never been addressed in previous studies. This study aimed to evaluate the predictive values of the heart rate variability (HRV) indices for long-term VA outcomes.MethodsThis retrospective study was conducted using a prospectively established cohort enrolling 175 adult chronic hemodialysis patients (100 women, mean age 65.1 ± 12.9 years) from June 2010 to August 2010. Each participant received a series of HRV measurements at enrollment. After a 60-month follow-up period, we retrospectively reviewed all events and therapeutic procedures of the VAs which existed at the enrollment and during the follow-up period.ResultsDuring the 60-month follow-up period, 37 (26.8%) had VAF but 138 (73.2%) didn’t. The values of most HRV indices were statistically increased during hemodialysis since initiation in the non-VAF group, but not in the VAF group. Among all participants, the independent indicators for VAF included higher normalized high-frequency (nHF) activity [hazard ratio (HR) 1.04, p = 0.005], lower low-frequency/high-frequency (LF/HF) ratio (HR 0.80, p = 0.015), experience of urokinase therapy (HR 11.18, p = 0.002), percutaneous transluminal angioplasty (HR 2.88, p = 0.003) and surgical thrombectomy (HR 2.36, p = 0.035), as well as higher baseline serum creatinine (HR 1.07, p = 0.027) and potassium level (HR 1.58, p = 0.037). In subgroup analysis, a lower sympathetic activity indicated by lower LF/HF ratio was an independent indicator for VAF (HR 0.61, p = 0.03) for tunneled cuffed catheter, but conversely played a protective role against VAF (HR 1.27, p = 0.002) for arteriovenous fistula.ConclusionsHRV is a useful tool for predicting long-term VAF among hemodialysis patients.

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Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV

Cited by 2 publications

References 7 publications

Cardiac autonomic neuropathy evaluated by time asymmetric analysis for heart rate variability in patients with peritoneal dialysis

Cardiac autonomic neuropathy evaluated by time asymmetric analysis for heart rate variability in patients with peritoneal dialysis

Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients

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