Heart rate variability in Parkinson’s disease unaffected by deep brain stimulation

Trachani, Eftichia; Constantoyannis, Constantine; Sakellaropoulos, George; Stavrinou, Maria L.; Nikiforidis, George; Chroni, Elisabeth

doi:10.1111/j.1600-0404.2011.1605.x

Cited by 19 publications

(20 citation statements)

References 34 publications

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“…Overall, these studies found reduced HRV-using both time-domain and frequencydomain measures-in PD patients compared to controls. [18][19][20][21] The evidence that cardiac dysautonomia is present before the motor onset of PD is more limited. The Cardiovascular Health Study, a community-based cohort of men and women age 65 years and older, measured HRV in 24-hour Holter records from 1,587 individuals free of PD, 44 of whom developed PD during 14 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

Alonso

Huang

Mosley

et al. 2015

Annals of Neurology

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Objectives Autonomic dysfunction frequently occurs in the context of Parkinson’s disease (PD) and may precede onset of motor symptoms. Limited data exist on the prospective association of heart rate variability (HRV), a marker of autonomic function, with PD risk. Methods We included 12,162 participants of the Atherosclerosis Risk in Communities (ARIC) study, a community-based cohort, without a diagnosis of PD at baseline (1987-89) and with available HRV data (mean age 54, 57% women). A 2-minute electrocardiogram was used to measure HRV. Incident PD was identified through 2008 from multiple sources, and adjudicated. Multivariable Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of PD by quartiles of HRV measurements. Results During a mean follow-up of 18 years, we identified 78 incident PD cases. Lower values of the root mean square of successive differences in normal-to-normal R-R intervals (rMSSD) and standard deviation of normal-to-normal R-R intervals (SDNN), markers of parasympathetic activity and total variability respectively, were associated with higher PD risk during follow-up. In multivariable models, the HR (95%CI) of PD in the bottom quartiles of rMSSD and SDNN compared to the top quartiles were 2.1 (1.0-4.3) and 2.9 (1.4-6.1), respectively. Other measures of cardiac autonomic function, including mean RR interval and frequency-domain measurements, were not associated with PD risk. Interpretation In this prospective cohort, decreased HRV was associated with an increased risk of PD. Assessment of cardiac autonomic function may help identify individuals at risk for PD.

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Section: Discussionmentioning

confidence: 99%

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

Alonso

Huang

Mosley

et al. 2015

Annals of Neurology

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“…Those findings describe autonomic responses, during only a limited period of time, with large individual variability, promoting a limited view of the autonomic mechanisms in control of cardiac activity [9,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in ANS in Parkinson's patients include perturbations in cardiovascular regulation, hypotension, especially in orthostatic position, and sexual dysfunction [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Measures of Heart Rate Variability in Patients with Idiopathic Parkinson’s Disease

Soares¹

2013

J Alzheimers Dis Parkinsonism

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“…These findings were supported by a more recent controlled study that reported improved orthostatic hypotension in PD patients after DBS. 76 Another controlled study including 28 PD patients proposed that the vagal component of the arterial-cardiac baroreflex improved postoperatively. 77 Dafsari et al .…”

Section: Dbs Effect On the Autonomic Domainmentioning

confidence: 99%

The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence

Kurtis

Rajah

Delgado

et al. 2017

npj Parkinson's Disease

120

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The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson’s disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations. There is level I evidence on the effect of DBS on cognition and mood. Slight cognitive decline has been reported in most class I studies, although the functional effect is probably minimal. Two randomized prospective studies reported no change in depression while improvement of anxiety has been reported by a class I trial. Prospective cohort studies point to improvement of hyperdopaminergic behaviors, such as impulse control disorders, while others report that hypodopaminergic states, like apathy, can appear after DBS. There is only class III evidence supporting the benefit of DBS on other NMS such as nocturnal sleep, pain, dysautonomia (urinary, gastrointestinal, cardiovascular, and sweating), and weight loss. Although preliminary results are promising, randomized prospectively controlled trials with NMS as primary end points are necessary to further explore the effect of DBS on these often invalidating symptoms and offer conclusions about efficacy.

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Heart rate variability in Parkinson’s disease unaffected by deep brain stimulation

Abstract: STN-DBS offered no considerable impact on autonomic cardiovascular control.

Cited by 19 publications

References 34 publications

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

Measures of Heart Rate Variability in Patients with Idiopathic Parkinson’s Disease

The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence

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