Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Abstract

BackgroundCardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. OPEN ACCESS Citation: Benichou T, Pereira B, Mermillod M, Tauveron I, Pfabigan D, Maqdasy S, et al. (2018) Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis. PLoS ONE 13(4): e0195166. https://doi.org/10.-2.13 to -0.91), lower LF (-1.08; -1.46 to -0.69]), and lower HF (-0.79; -1.09 to -0.50). LF/HF did not differ between groups. Levels of blood glucose and HbA1c were associated with several HRV parameters, as well as Time from diagnosis of T2DM ConclusionsT2DM was associated with an overall decrease in the HRV of T2DM patients. Both sympathetic and parasympathetic activity were decreased, which can be explained by the deleterious effects of altered glucose metabolism on HRV, leading to cardiac autonomic neuropathy.

Toward a social psychophysiology of vagally mediated heart rate variability: Concepts and methods in self‐regulation, emotion, and interpersonal processes

“…The importance of influences on resting vmHRV is underscored by evidence of its robust associations with physical health and well‐being (Hillebrand et al, ; Thayer et al, ; Thayer & Lane, ), and by its potential role as a mechanism linking personality, emotion and interpersonal processes with subsequent health (Kemp, Koenig, & Thayer, ). However, research on associations with physical health must consider the possibility of reverse causality, as reduced resting vmHRV can both contribute to and result from disease (e.g., Benichou et al, ).…”

Relationship between heart rate variability and carotid intima‐media thickness in the Brazilian Longitudinal Study of Adult Health – ELSA‐Brasil

“…Nonetheless, we observed a tendency for increased risk at low HF power, when only patients with diabetes were considered. This may be a result of the marked vagal impairment involved in the pathophysiology of diabetes (Goit et al, 2012;Benichou et al, 2018;Hoshi et al, 2019). Then, our findings suggest that low HRV in patients with diabetes may benefit from further investigation on the vascular function.…”

“…This may be a result of the marked vagal impairment involved in the pathophysiology of diabetes (Goit et al, 2012;Benichou et al, 2018;Hoshi et al, 2019). Therefore, HRV may not indicate alterations of the vascular wall in this setting, probably reflecting other pathophysiological changes.…”

Simplified electrophysiological approach combining a point‐of‐care nerve conduction device and an electrocardiogram produces an accurate diagnosis of diabetic polyneuropathy

“…CAN is assessed for cardiovascular risk stratification of patients. Various CAN evaluation methods have been proposed: the standard deviation of the R‐R interval, coefficient of variation of R‐R intervals (CV R‐R ), low‐frequency spectra/high‐frequency spectra, percent of difference between adjacent normal R‐R intervals >50 ms, root mean square successive difference and Cardiovascular Autonomic Reflex Test 12 , 13 , 14 . Among them, CV R‐R is commonly utilized to evaluate autonomic function in Japan.…”