Heart rate variability in β-thalassemic mice

Incharoen, Tanat; Thephinlap, Chontida; Srichairatanakool, Somdet; Chattipakorn, Siriporn C.; Winichagoon, Pranee; Fucharoen, Suthat; Vadolas, Jim; Chattipakorn, Nipon

doi:10.1016/j.ijcard.2006.08.076

Cited by 25 publications

(34 citation statements)

References 15 publications

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“…increased LF/HF ratio), increased stroke volume (SV) and cardiac output (CO) when compared with normal mice. 14,15,19 This indicates a high-output state in b-thalassemic mice, which is similar to that found in patients with thalassemia. 7 High-output state, as shown by increased stroke volume (SV) and cardiac output (CO), develops as a consequence of prolonged tissue hypoxia, resulting from chronic anemia in beta-thalassemia patients 34,35 and animal models.…”

Section: The Hearts Of B-thalassemic Micesupporting

confidence: 80%

“…Currently, the model mostly used to study the heart in this condition is the heterozygous (Hbb th-3 /Hbb þ ) b-thalassemic genotype. [14][15][16][17][18][19] Mice heterozygous for the deletion (Hbb th-3 /Hbb þ ) showed characteristics typical of severe thalassemia such as: a significant decrease in hematocrit (Hct), hemoglobin (Hb), red blood cell (RBC) counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC), and increased reticulocyte counts, serum bilirubin concentrations, and red cell distribution width (RDW). 13 Heterozygous animals also exhibit bone deformities and splenic enlargement due to increased hematopoiesis which is a typical picture of b-thalassemia, and a spontaneous iron overload in the spleen, liver, and kidneys in this mouse model has been found.…”

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confidence: 99%

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Cardiac complications in beta-thalassemia: From mice to men

Kumfu

Fucharoen

Chattipakorn

2017

Exp Biol Med (Maywood)

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Iron overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. Since investigation of iron overload cardiomyopathy in thalassemia patients has many limitations, a search for an animal model for this condition has been ongoing for decades. In the past decades, there is no doubt that the use of b-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects of iron overload on the hearts of b-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. AbstractBeta-thalassemia is an inherited hemoglobin disorder caused by reduced or absent synthesis of the beta globin chains of hemoglobin. This results in variable outcomes ranging from clinically asymptomatic to severe anemia, which then typically requires regular blood transfusion. These regular blood transfusions can result in an iron overload condition. The iron overload condition can lead to iron accumulation in various organs, especially in the heart, leading to iron overload cardiomyopathy, which is the major cause of mortality in patients with thalassemia. In the past decades, there is no doubt that the use of b-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects that iron overload has on the hearts of b-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. The in-depth understanding of biomolecular alterations in the heart of these iron overload thalassemic mice will help give guidance for more effective therapeutic approaches in the near future.

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Section: The Hearts Of B-thalassemic Micesupporting

confidence: 80%

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confidence: 99%

Cardiac complications in beta-thalassemia: From mice to men

Kumfu

Fucharoen

Chattipakorn

2017

Exp Biol Med (Maywood)

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“…During ECG recording, rats were placed in a restraint and prohibited from movement (Incharoen et al 2007, Raher et al 2008, Kumfu et al 2012. The highfrequency (HF, 0.6-3.0 Hz) component, representing cardiac parasympathetic activity, and low-frequency (LF, 0.2-0.6 Hz) component, representing cardiac sympathetic and parasympathetic activity, were determined using the MATLAB program (Raher et al 2008).…”

Section: Hrv Analysismentioning

confidence: 99%

“…An increased LF:HF ratio (i.e. depressed HRV) indicated a cardiac sympathovagal imbalance (Incharoen et al 2007). …”

Section: Hrv Analysismentioning

confidence: 99%

Protocatechuic acid exerts a cardioprotective effect in type 1 diabetic rats

Semaming¹,

Kumfu²,

Pannangpetch³

et al. 2014

Journal of Endocrinology

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Oxidative stress has been shown to play an important role in the pathogenesis of diabetesinduced cardiac dysfunction. Protocatechuic acid (PCA) is a phenolic compound, a main metabolite of anthocyanin, which has been reported to display various pharmacological properties. We proposed the hypothesis that PCA exerts cardioprotection in type 1 diabetic (T1DM) rats. T1DM was induced in male Sprague-Dawley rats by a single i.p. injection of 50 mg/kg streptozotocin (STZ) and groups of these animals received the following treatments for 12 weeks: i) oral administration of vehicle, ii) oral administration of PCA at a dose of 50 mg/kg per day, iii) oral administration of PCA at a dose of 100 mg/kg per day, iv) s.c. injection of insulin at a dose of 4 U/kg per day, and v) a combination of PCA, 100 mg/kg per day and insulin, 4 U/kg per day. Metabolic parameters, results from echocardiography, and heart rate variability were monitored every 4 weeks, and the HbA1c, cardiac malondialdehyde (MDA), cardiac mitochondrial function, and cardiac BAX/BCL2 expression were evaluated at the end of treatment. PCA, insulin, and combined drug treatments significantly improved metabolic parameters and cardiac function as shown by increased percentage fractional shortening and percentage left ventricular ejection fraction and decreased low-frequency:high-frequency ratio in T1DM rats. Moreover, all treatments significantly decreased plasma HbA1c and cardiac MDA levels, improved cardiac mitochondrial function, and increased BCL2 expression. Our results demonstrated for the first time, to our knowledge, the efficacy of PCA in improving cardiac function and cardiac autonomic balance, preventing cardiac mitochondrial dysfunction, and increasing anti-apoptotic protein in STZ-induced T1DM rats. Thus, PCA possesses a potential cardioprotective effect and could restore cardiac function when combined with insulin treatment. These findings indicated that supplementation with PCA might be helpful for the prevention and alleviation of cardiovascular complications in T1DM.

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“…Incharoen et al [92] 810 wildtype and 810 heterozygous betaknockout mice Prospective Higher LF ⁄ HF ratio in thalassemic mice than those in the wild type…”

Section: Hrv In Thalassemia Majormentioning

confidence: 99%

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Koonrungsesomboon

Chattipakorn²,

Fucharoen³

et al. 2013

WJC

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Myocardial siderosis is known as the major cause of death in thalassemia major (TM) patients since it can lead to iron overload cardiomyopathy. Although this condition can be prevented if timely effective intensive chelation is given to patients, the mortality rate of iron overload cardiomyopathy still remains high due to late detection of this condition. Various direct and indirect methods of iron assessment, including serum ferritin level, echocardiogram, non-transferrin-bound iron, cardiac magnetic resonance T2*, heart rate variability, and liver biopsy and myocardial biopsy, have been pro- REVIEW 270August 26, 2013|Volume 5|Issue 8|

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Heart rate variability in β-thalassemic mice

Cited by 25 publications

References 15 publications

Cardiac complications in beta-thalassemia: From mice to men

Cardiac complications in beta-thalassemia: From mice to men

Protocatechuic acid exerts a cardioprotective effect in type 1 diabetic rats

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

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