Heart rate variability, interoceptive accuracy and functional connectivity in middle-aged and older patients with depression

Blickle, Manuel; Klüpfel, Catherina; Homola, György A.; Gamer, Matthias; Herrmann, Martin J.; Störk, Stefan; Gelbrich, Götz; Heuschmann, Peter U.; Deckert, Jürgen; Pham, Mirko; Menke, Andreas

doi:10.1016/j.jpsychires.2023.11.044

Journal of Psychiatric Research

2024

DOI: 10.1016/j.jpsychires.2023.11.044

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Heart rate variability, interoceptive accuracy and functional connectivity in middle-aged and older patients with depression

Manuel Blickle,

Catherina Klüpfel,

György A. Homola

et al.

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Impaired functional brain-heart interplay sustains emotion dysregulation in depressed individuals

Catrambone,

Mura,

Patron

et al. 2024

Preprint

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Depression is a leading worldwide cause of mental disorders and disability, strongly affecting emotional processing and regulation. Its dysfunctional psycho-physiological dynamics may be part of the a nervous-system-wise symptomatology, impacting not only patients’ psyche but also significantly influencing functional cardiovascular dynamics. Therefore, depression serves as an exemplary pathological manifestation of the dysfunctional interaction between the central and autonomic nervous systems. While recent literature has been developing specific techniques to quantify such interactions, often referred to as functional Brain-Heart Interplay (BHI), the quantitative role of BHI dynamics in depression is largely unknown. This study aims to experimentally unveil BHI patterns specific to emotional regulation and processing in subjects exhibiting depressive symptoms compared to healthy controls. Results were gathered from a cohort of 72 individuals and indicate that depressive symptoms are associated with a continuous efferent central-to-peripheral hyperactivity and an afferent peripheral-to-central hypoactivity. This hypoactivity appears to be specific to negative emotional processing. This study offers novel insights into the systemic investigation of the neuro-physiological bases of depression.

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Impaired functional brain-heart interplay sustains emotion dysregulation in depressed individuals

Catrambone,

Mura,

Patron

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Heart rate variability, interoceptive accuracy and functional connectivity in middle-aged and older patients with depression

Cited by 1 publication

References 68 publications

Impaired functional brain-heart interplay sustains emotion dysregulation in depressed individuals

Impaired functional brain-heart interplay sustains emotion dysregulation in depressed individuals

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