Heart selenoproteins status of metabolic syndrome-exposed pups: A potential target for attenuating cardiac damage

Serrano, A. Lesmes; Nogales, Fátima; Sánchez-Sobrino, Paula; Murillo, María Luisa Ojeda; Carreras, Olimpia; Ojeda, María Luisa

doi:10.1002/mnfr.201600511

Cited by 8 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Female pups present hepatomegaly and extremely low insulin serum levels, indicating a greater metabolic disruption in these pups; in male pups, growth and development are affected to a greater degree. Both sexes presented albuminuria, hypernatremia, and hyperaldosteronemia, leading to a hypertensive status [ 141 , 142 ]. All these changes difficult the weaning process as it is expressed in Figure 4 .…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

“…Se and selenoproteins play an important role in heart development, function, and cardioprotection [ 148 ]. In the HFruD-model used, heart Se deposits in pups were depleted without difference among sex, leading to lower antioxidant GPx1 and GPx4 expression and activity in cardiomyocytes [ 142 ]. Therefore, lipid and protein oxidation take place in cardiomyocytes, affecting correct heart function.…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

“…This might be because GPx3 comes directly from the plasma delivered by the kidney, where it was increased [ 141 ]. Therefore, GPx3, the only GPx with extracellular antioxidant activity, seems to be sequestered toward the heart matrix of MetS pups in an attempt to maintain its antioxidant balance, which was profoundly altered [ 142 ]. Moreover, GPx3 has a preventive role in CVD, since it avoids myocardial damage by decreasing Ca 2+ -dependent endoplasmatic reticulum stress (ERS), maintains the bioavailability of NO in the vascular system, and regulates the cardiopathology that accompanies diabetes [ 142 , 171 , 172 ].…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

“…Heart SelP expression was unaltered in MetS pups; however, no relationship among SelP and AMPK activation was found, since in these pups AMPK activation was decreased [ 142 ]. Low AMPK activity leads to a lower ATP generation, compromising the functionality and ability of the heart to contract, a tissue with a highly energetic demand.…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

2022

Self Cite

View full text Add to dashboard Cite

Selenium (Se) is an essential trace element mainly known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins. Some of them are related to insulin resistance (IR) and metabolic syndrome (MetS) generation, modulating reactive oxygen species (ROS), and the energetic sensor AMP-activated protein kinase (AMPK); they can also regulate the nuclear transcription factor kappa-B (NF-kB), leading to changes in inflammation production. Selenoproteins are also necessary for the correct synthesis of insulin and thyroid hormones. They are also involved in endocrine central regulation of appetite and energy homeostasis, affecting growth and development. MetS, a complex metabolic disorder, can appear during gestation and lactation in mothers, leading to energetic and metabolic changes in their offspring that, according to the metabolic programming theory, will produce cardiovascular and metabolic diseases later in life. However, there is a gap concerning Se tissue levels and selenoproteins’ implications in MetS generation, which is even greater during MetS programming. This narrative review also provides an overview of the existing evidence, based on experimental research from our laboratory, which strengthens the fact that maternal MetS leads to changes in Se tissue deposits and antioxidant selenoproteins’ expression in their offspring. These changes contribute to alterations in tissues’ oxidative damage, inflammation, energy balance, and tissue function, mainly in the heart. Se imbalance also could modulate appetite and endocrine energy balance, affecting pups’ growth and development. MetS pups present a profile similar to that of diabetes type 1, which also appeared when dams were exposed to low-Se dietary supply. Maternal Se supplementation should be taken into account if, during gestation and/or lactation periods, there are suspicions of endocrine energy imbalance in the offspring, such as MetS. It could be an interesting therapy to induce heart reprogramming. However, more studies are necessary.

show abstract

Section: Selenium Mets Programmingmentioning

confidence: 99%

Section: Selenium Mets Programmingmentioning

confidence: 99%

Section: Selenium Mets Programmingmentioning

confidence: 99%

Section: Selenium Mets Programmingmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…According to this, infant pathologies related to OS exposure during gestation and/or lactation that lead to metabolic programing disorders like metabolic syndrome (MS) or fetal alcohol syndrome disorders (FASD), have been reported to be associated with a low Se maternal status and IUGR [ 117 , 118 , 119 , 120 ].…”

Section: Oxidative Stress-programming Pathologies and Sementioning

confidence: 99%

Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

et al. 2021

Self Cite

View full text Add to dashboard Cite

Nutrients consumed by mothers during pregnancy and lactation can exert permanent effects upon infant developing tissues, which could represent an important risk factor for diseases during adulthood. One of the important nutrients that contributes to regulating the cell cycle and tissue development and functionality is the trace element selenium (Se). Maternal Se requirements increase during gestation and lactation. Se performs its biological action by forming part of 25 selenoproteins, most of which have antioxidant properties, such as glutathione peroxidases (GPxs) and selenoprotein P (SELENOP). These are also related to endocrine regulation, appetite, growth and energy homeostasis. In experimental studies, it has been found that low dietary maternal Se supply leads to an important oxidative disruption in dams and in their progeny. This oxidative stress deeply affects gestational parameters, and leads to intrauterine growth retardation and abnormal development of tissues, which is related to endocrine metabolic imbalance. Childhood pathologies related to oxidative stress during pregnancy and/or lactation, leading to metabolic programing disorders like fetal alcohol spectrum disorders (FASD), have been associated with a low maternal Se status and intrauterine growth retardation. In this context, Se supplementation therapy to alcoholic dams avoids growth retardation, hepatic oxidation and improves gestational and breastfeeding parameters in FASD pups. This review is focused on the important role that Se plays during intrauterine and breastfeeding development, in order to highlight it as a marker and/or a nutritional strategy to avoid diverse fetal programming disorders related to oxidative stress.

show abstract

Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis

et al. 2018

View full text Add to dashboard Cite

Heart selenoproteins status of metabolic syndrome-exposed pups: A potential target for attenuating cardiac damage

Abstract: These data indicate that dietary Se supplementation could be an inexpensive therapy for avoiding future cardiovascular complication in the progeny of MS dams.

Cited by 8 publications

References 36 publications

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis

Contact Info

Product

Resources

About