A novel approach for separating heart sound signals (HSSs) from lung sound recordings is presented. The approach is based on blind source extraction (BSE) with second-order statistics (SOS), which exploits the quasi-periodicity of the HSSs. The method is evaluated on both synthetic periodic signals of known period mixed with temporally white Gaussian noise (WGN) as well as on real quasi periodic HSSs mixed with lung sound signals (LSSs). Qualitative evaluation involving comparison of the power spectral densities (PSDs) of the extracted signals, by the proposed method and by the JADE algorithm, and that of the original signal is performed for the case of real data. Separation results confirm the utility of the proposed approach, although departure from strict periodicity may impact performance.Index Terms-Blind source extraction, second order statistics, periodicity, nonstationarity, heart sound signal and lung sound recordings.