Heart-specific expression of FGF-16 and a potential role in postnatal cardioprotection

Wang, Jie; Sontag, David P.; Cattini, Peter A.

doi:10.1016/j.cytogfr.2014.07.007

Cited by 18 publications

(10 citation statements)

References 77 publications

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“…FGF16 expression is promoted by FGF2 in cultured cardiomyocytes. These findings indicate that FGF16 prevents cardiac hypertrophy and fibrosis by competing with FGF2 for FGFR1c (Itoh and Ohta, 2013 ; Matsumoto et al, 2013 ; Wang J. et al, 2015 ).…”

Section: Pathophysiological Roles Of Fgfs Indicated By Fgf mentioning

confidence: 97%

Roles of FGF Signals in Heart Development, Health, and Disease

Itoh

Ohta

Nakayama

et al. 2016

Front. Cell Dev. Biol.

110

103

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The heart provides the body with oxygen and nutrients and assists in the removal of metabolic waste through the blood vessels of the circulatory system. It is the first organ to form during embryonic morphogenesis. FGFs with diverse functions in development, health, and disease are signaling proteins, mostly as paracrine growth factors or endocrine hormones. The human/mouse FGF family comprises 22 members. Findings obtained from mouse models and human diseases with FGF signaling disorders have indicated that several FGFs are involved in heart development, health, and disease. Paracrine FGFs including FGF8, FGF9, FGF10, and FGF16 act as paracrine signals in embryonic heart development. In addition, paracrine FGFs including FGF2, FGF9, FGF10, and FGF16 play roles as paracrine signals in postnatal heart pathophysiology. Although FGF15/19, FGF21, and FGF23 are typical endocrine FGFs, they mainly function as paracrine signals in heart development or pathophysiology. In heart diseases, serum FGF15/19 levels or FGF21 and FGF23 levels decrease or increase, respectively, indicating their possible roles in heart pathophysiology. FGF2 and FGF10 also stimulate the cardiac differentiation of cultured stem cells and cardiac reprogramming of cultured fibroblasts. These findings provide new insights into the roles of FGF signaling in the heart and potential therapeutic strategies for cardiac disorders.

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Section: Pathophysiological Roles Of Fgfs Indicated By Fgf mentioning

confidence: 97%

Roles of FGF Signals in Heart Development, Health, and Disease

Itoh

Ohta

Nakayama

et al. 2016

Front. Cell Dev. Biol.

110

103

View full text Add to dashboard Cite

show abstract

“…FGF signaling is cardioprotective in various models of myocardial infarction (MI) (Kardami et al, 2007; Khosravi et al, 2021; Tanajak et al, 2015; J. Wang, Sontag, & Cattini, 2015; S. Wang, Li, et al, 2018). Mature cardiomyocytes express high levels of Fgfr1 and Fgfr3 , lower levels of Fgfr2 and Fgfr4 , and the endocrine FGF cofactor, βKlotho (Grabner et al, 2015; Liu et al, 2013; Planavila et al, 2013).…”

Section: Selected Topics In Genetics Development Regeneration and Dis...mentioning

confidence: 99%

New developments in the biology of fibroblast growth factors

Ornitz

Itoh

2022

WIREs Mechanisms of Disease

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The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine kinases (FGFRs 1-4) and four intracellular proteins (intracellular FGFs or iFGFs) that primarily function to regulate the activity of voltagegated sodium channels and other molecules. The canonical FGFs, endocrine FGFs, and iFGFs have been reviewed extensively by us and others. In this review, we briefly summarize past reviews and then focus on new developments in the FGF field since our last review in 2015. Some of the highlights in the past 6 years include the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, an expanded understanding of endocrine FGF signaling, functions for FGF signaling in stem cell pluripotency and differentiation, roles for FGF signaling in tissue homeostasis and regeneration, a continuing elaboration of mechanisms of FGF signaling in development, and an expanding appreciation of roles for FGF signaling in neuropsychiatric diseases.

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“…Since the normal and infarct heart expresses FGF9 only at low levels (108), it is thought that FGF9 release by infiltrating bone marrow cells mediates adaptive cardiac hypertrophy following myocardial infarct (107). Finally, FGF16 seems to be predominantly expressed in the adult heart (109) where it has cardio-protective effects (110). Similar to FGF2 knockout mice, AngII-induced cardiac hypertrophy and fibrosis is increased in mice lacking FGF16 (111).…”

Section: The Effects Of Paracrine Fibroblast Growth Factors On the Heartmentioning

confidence: 99%

Cardiac actions of fibroblast growth factor 23

Faul

2017

Bone

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Fibroblast growth factors (FGF) are mitogenic signal mediators that induce cell proliferation and survival. Although cardiac myocytes are post-mitotic, they have been shown to be able to respond to local and circulating FGFs. While precise molecular mechanisms are not well characterized, some FGF family members have been shown to induce cardiac remodeling under physiologic conditions by mediating hypertrophic growth in cardiac myocytes and by promoting angiogenesis, both events leading to increased cardiac function and output. This FGF-mediated physiologic scenario might transition into a pathologic situation involving cardiac cell death, fibrosis and inflammation, and eventually cardiac dysfunction and heart failure. As discussed here, cardiac actions of FGFs - with the majority of studies focusing on FGF2, FGF21 and FGF23 - and their specific FGF receptors (FGFR) and precise target cell types within the heart, are currently under experimental investigation. Especially cardiac effects of endocrine FGFs entered center stage over the past five years, as they might provide communication routes that couple metabolic mechanisms, such as bone-regulated phosphate homeostasis, or metabolic stress, such as hyperphosphatemia associated with kidney injury, with changes in cardiac structure and function. In this context, it has been shown that elevated serum FGF23 can directly tackle cardiac myocytes via FGFR4 thereby contributing to cardiac hypertrophy in models of chronic kidney disease, also called uremic cardiomyopathy. Precise characterization of FGFs and their origin and regulation of expression, and even more importantly, the identification of the FGFR isoforms that mediate their cardiac actions should help to develop novel pharmacological interventions for heart failure, such as FGFR4 inhibition to tackle uremic cardiomyopathy.

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Heart-specific expression of FGF-16 and a potential role in postnatal cardioprotection

Cited by 18 publications

References 77 publications

Roles of FGF Signals in Heart Development, Health, and Disease

Roles of FGF Signals in Heart Development, Health, and Disease

New developments in the biology of fibroblast growth factors

Cardiac actions of fibroblast growth factor 23

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