Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

Abstract

Heart-type fatty acid-binding protein (H-FABP) is a non-invasive bio-marker, with high sensitivity and specificity, being capable to point out the myocardial injury and to predict major adverse cardiovascular events (MACE). Cardiac rehabilitation program, through a complex and sustained post-interventional management plays an important role in reducing the plasma levels of H-FABP. In the study, which included 120 post-coronary artery bypass (CABG) patients, we analyzed the link between low levels of general post-surgical health status and the presence of cardiovascular risk factors, common biochemical markers, and especially the role played by diabetic status in lowering the plasma H-FABP levels. From the group, 65 patients had been diagnosed with type 2 Diabetes Mellitus (T2DM). The H-FABP values decreased both in diabetics and in non-diabetics between the two phases of CR, 6 months away from CABG. More than half of the patients had important reduction of H-FABP, at 6 months after the onset of CR program. Half of the group registered a smaller reduction of H-FABP, but more noticeable in diabetics. Ischemic lesion during open heart surgery is linked to high levels of H-FABP and with an occurence risk of postoperative atrial fibrillation, that can be also triggered and sustained by multiple endocrine conditions related to aging. Thus, metabolic control should always remain a target of the complex management in cardiac rehabilitation.

Significance of Left Atrial Electromechanical Function for Atrial Fibrillation Prediction after Cardiac Surgery

“…Table (4) showed that concerning P wave duration, there was no statistical difference between both groups (p = 0.131) where P wave duration in POAF was 113.98 ± 14.36 ms compared to 112.76 ± 13.62 ms in -ve POAF group. As regards p wave dispersion, there was no statistical difference between both groups (p = 0.213) where P wave dispersion in POAF was 63.6 ± 15.23 ms compared to 61.51 ± 12.66 ms in -ve POAF group.…”

“…After mitral valve surgery (MVS), the probability of POAF was greater than after coronary artery bypass grafting (CABG) or surgery. Clearly, postoperative POAF should be avoided and managed (4) . In order to identify high-risk patients before surgery and provide them with appropriate preventive regimens, several approaches have been evaluated for calculating the risk of developing POAF (5) .…”

“…TACT can be accurately estimated using the time elapsed between the start of the P-wave on the ECG and the peak of the A' lateral wave on tissue Doppler imaging (TDI; PA-TDI duration). The length of the PA-TDI has been linked to several types of AF and the frequency with which they reoccur (4) . All participants in this study were subjected to the following: I.…”